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VMAT2 is a God gene. A bad project called Funvax is not a good news; See the video from university (4mn 28s)
http://www.youtube.com/watch?v=XGMkadUGIWE&feature=player_embedded#!
inhibition of VMAT2
VMAT2 is essential in the presynaptic neuron’s ability to facilitate the release of neurotransmitters into the synaptic cleft. If VMAT2 function is inhibited or compromised, neurotransmitters, such as dopamine, cannot be released via normal transport (exocytosis, action potential) into the synapse. VMAT2 function inhibition can have many various effects on neurotransmitter function. Specifically of importance is its effect on the neurotransmitter dopamine.
Dopamine, specifically, is highly neurotoxic to most cellular structures, due to its ability to auto-oxidize in the presence of oxygen radicals. Dopamine, and other neurotransmitters, are metabolized via various processes into various substances, by enzymes such as monoamine oxidase (MAO), catechol-O-methyl transferase (COMT), and dopamine beta hydroxylase (DBH).
Vesicles normally protect dopamine from auto-oxidation and metabolism by monoamine oxidase and COMT. Impaired VMAT2 function/activity may contribute to symptoms of depression, anxiety, restless leg syndrome, akathisia, Parkinson’s disease, social anxiety, and many other conditions, via inhibition of normal dopamine release into the synapse. Long-term use of amphetamine and methamphetamine causes long-lasting reductions in VMAT2 expression/activity, similar to chronic use of cocaine. This reduction of VMAT2 activity contributes significantly to the neurotoxic effects of amphetamine and methamphetamine.
Cocaine users display a marked reduction in VMAT2 immunoreactivity. Sufferers of cocaine-induced mood disorders displayed a significant loss of VMAT2 immunoreactivity; this might reflect damage to dopamine axon terminals in the striatum. These neuronal changes could play a role in causing disordered mood and motivational processes in more severely addicted users.[5]
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