I was very depressed on and off since I can remember and have been on several different anti-depressants over the years with little or no relief of everyone. Now, since I’m on methadone, I feel like a totally different person.I found it in an attempt to understand my own problems and believe me, this is not an attempt to try to justify using a drug. The ideal solution is to find something that can mimic mental benefits that people get of opiates, without the problems of addiction tolerance, and of course with respiratory failure.