[PS3Player]

Doctor,

You posted thyroid ranges of

Free T3 between 340 to 420 pg/dL (5.24-6.47 pmol/L)
Total T4 between 8.0 to 12.0 ug/dL (102.96 to 154.44 nmol/L)
TSH between 0.050 to 0.8 uIU/mL

What happens if a person is in that range for T3 and T4 but TSH is around 2.4? Would that still be acceptable…. or could that hinder thyroid function..

[PS3Player]

From my understanding, slow release T3 compound would be necessary to clear out Reverse T3..I’m not a doctor, but that is what I’ve researched on some sites…

I do have a question though..would a Rt3/Ft3 ratio of 15 be considered high and should require such treatment?

[PS3Player]

Thanks for clarifying this doctor:)

[PS3Player]

More on this…

http://en.wikipedia.org/wiki/Tetrahydrobiopterin

Tetrahydrobiopterin (THB, BH4; Kuvan) or sapropterin, is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine (5-HT)), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and nitric oxide (NO).
THB was discovered to play a role as an enzymatic cofactor. The first enzyme found to use THB is phenylalanine hydroxylase (PAH).

Biosynthesis

THB is biosynthesized from guanosine triphosphate (GTP) by three chemical reactions mediated by the enzymes (GTP cyclohydrolase I (GTPCH), 6-pyruvoyltetrahydropterin synthase (PTPS), and sepiapterin reductase (SR).[2]

Functions

THB has the following responsibilities as a cofactor:

Tryptophan hydroxylase (TPH) for the conversion of L-tryptophan (TRP) to 5-hydroxytryptophan (5-HTP)
Phenylalanine hydroxylase (PAH) for conversion of L-phenylalanine (PHE) to L-tyrosine (TYR)
Tyrosine hydroxylase (TH) for the conversion of L-tyrosine to L-DOPA (DOPA)
Nitric oxide synthase (NOS) for conversion of a guanidino nitrogen of L-arginine (L-Arg) to nitric oxide (NO)
Glyceryl ether monooxygenase (GEMO) for the conversion of 1-alkyl-sn-glycerol to 1-hydroxyalkyl-sn-glycerol

[PS3Player]

Hi Dr. Mariano,

First off, I would like to thank you for all of the time and effort that you invest in providing deep and concise explanations on your discussion forum. It is quite useful and educational.

I’m a long term finasteride sufferer who took finasteride for a very short period of time(2 months) and never recovered..It’s been many years and the only thing that makes me feel somewhat better is taking supplements like: 5-HTP, Mucana Prurines, and Yohimbe. Even with high normal testosterone, I’m still not recovered unless I take those supplements(which gets me to 50% of where I was pre-finasteride).. I do not understand why my body has not recoverd(I’m in my late 20’s….)

I truely believe our problem could be neurological in nature(dopamine/serotonin imbalances/NE/Epinerphine) and was curious if you are familiar with tetrahydrobiopterin deficiency. I heard this type of deficiency can lead to many imbalances(hormones, neurological, thyroid & adrenals). The drug prescribed to treat it is called BH4 which helps breaks down the molecule phenyalaline. Would testing Phenyalaline dictate if one has a tetrahydrobiopterin deficiency, and if this states true, would the drug Kuvan(Sapropterin) help correct this condition?

[Author]

Posts