[mylilcappi]

Dr. M,
That first IGF-1 is way above the range I would think.
I know the second was isn’t but still above.

Taken by two different labs in a short time frame.
I don’t know which lab to believe. This concerns me..

Also, in one day,
I tested for several things.

different labs..
One lab my sodium and potassium were OVER range.
another lab normal..
In one day’s drawing.

I don’t know about these labs.

[mylilcappi]

Well, in April I had a DHEA-s come back at 237 (0-150)

Also in May I had a Dhea-s come back at 211 ((32-240)
In April I had a IGF-1 come back at 643 (81-250)
In may it came back 365 (94-252)

I had a GTT and suppressed GH..
Had mammogram negative
And just went to my gyno to have her check my breasts. She did not find anything.
Thanks for your time.

[mylilcappi]

Ok.. Sorry. I get so confused about all this.

Is was a total serum cortisol. using LC/MS/MS

It came back high 25.1. with a range of 4-20.6.
so I was wondering using this method of testing, is that a true reading? or would you know?
Thanks.
I know it’s not THAT high, but was just wondering.

[mylilcappi]

But what does it mean? What is the difference when they run that test vs. one without LC/MS/MS?

[mylilcappi]

Yogurt.. give it a shot..

Activia will give you your money back if if does not work within 2 wks. LOL

seriously, try yogurt everyday for a while…

[mylilcappi]

@DrMariano 623 wrote:

I define palpitations as excessively strong contractions of the heart that feel as if the heart is bouncing in one’s chest like a ball. It is uncomfortable to sleep on one’s chest when this occurs. The hyperdynamic heart contractions are palpable.

Generally, when doing hormone replacement therapy, this occurs when thyroid hormone is at too high a dose compared to the adrenal output of cortisol and other cortex hormones – even if one is hypothyroid. When this occurs, adrenal output of cortisol falls, norepinephrine increases, which then norepinephrine causes excessively strong heart contractions. It is important in this case to try and improve hypothalamic-pituitary-adrenal axis regulation so that adequate adrenal cortex output can occur to match up to the addition of thyroid.

—

Toprol – a beta blocker – not only blocks norepinephrine and reduces palpitations, it also prevents conversion of T4 to T3. Norepinephrine increases the production of deiodinase enzyme which converts T4 to T3. Toprol thus contributes to hypothyroidism. This is one way it contributes to depression.

—

By what evidence do you know that thyroid hormone is not getting into your cells?

Wait a minute.. GEEZE… It’s Lopressor that I just started to take.. Not toprol..
I looked at the bottle when i got it.. I knew that.. don’t know why I said toprol…

[mylilcappi]

@DrMariano 623 wrote:

I define palpitations as excessively strong contractions of the heart that feel as if the heart is bouncing in one’s chest like a ball. It is uncomfortable to sleep on one’s chest when this occurs. The hyperdynamic heart contractions are palpable.

Generally, when doing hormone replacement therapy, this occurs when thyroid hormone is at too high a dose compared to the adrenal output of cortisol and other cortex hormones – even if one is hypothyroid. When this occurs, adrenal output of cortisol falls, norepinephrine increases, which then norepinephrine causes excessively strong heart contractions. It is important in this case to try and improve hypothalamic-pituitary-adrenal axis regulation so that adequate adrenal cortex output can occur to match up to the addition of thyroid.

—

Toprol – a beta blocker – not only blocks norepinephrine and reduces palpitations, it also prevents conversion of T4 to T3. Norepinephrine increases the production of deiodinase enzyme which converts T4 to T3. Toprol thus contributes to hypothyroidism. This is one way it contributes to depression.

By what evidence do you know that thyroid hormone is not getting into your cells?

What about Nifedipine. I know this is a calcium channel blocker, and I know I need to get this straightened out, but this heart thing is scary and annoying to say the least. I knew when I read what you wrote, how you described it that that is what is happening to me..

[mylilcappi]

@DrMariano 624 wrote:

DHEA is not a good test since DHEA levels vary too frequently from very high to very low.

DHEA-s gives much more stable levels and is a better measure of DHEA output.

They were DHEA-S.. that S somehow gets left out alot.. But yes, it was DHEA-s…..

[mylilcappi]

@DrMariano 623 wrote:

I define palpitations as excessively strong contractions of the heart that feel as if the heart is bouncing in one’s chest like a ball. It is uncomfortable to sleep on one’s chest when this occurs. The hyperdynamic heart contractions are palpable.

Generally, when doing hormone replacement therapy, this occurs when thyroid hormone is at too high a dose compared to the adrenal output of cortisol and other cortex hormones – even if one is hypothyroid. When this occurs, adrenal output of cortisol falls, norepinephrine increases, which then norepinephrine causes excessively strong heart contractions. It is important in this case to try and improve hypothalamic-pituitary-adrenal axis regulation so that adequate adrenal cortex output can occur to match up to the addition of thyroid.

—

Toprol – a beta blocker – not only blocks norepinephrine and reduces palpitations, it also prevents conversion of T4 to T3. Norepinephrine increases the production of deiodinase enzyme which converts T4 to T3. Toprol thus contributes to hypothyroidism. This is one way it contributes to depression.

—

By what evidence do you know that thyroid hormone is not getting into your cells?

thank you Dr. M,
I know.. I just don’t know how to do that right now. That is improve the HPA axis. when I can’t take HC.. Oh that’s not such good news about Toprol.. I only started it last night.

I know that the thyroid is not getting into my cells simply by my symptoms. I have been hypo due to RAI for ten years. I was doing just fine on T4 alone. No depression, had energy, etc.. Just enjoying my life. I was a good converter. But now, I can just tell by everything.. Every aspect of my life. And I THINK it is because I don’t have the cortisol to help the thyroid get into my cells. I have been told that T4 alone will put more stress on the adrenals without enough cortisol. But I am afraid to stop taking my Levoxyl because basically, I don’t have a thyroid and I don’t know what it will do to me by not taking it, even though I can’t take HC.
As I have mentioned several times, and since you are so knowledgeable about meds and there interactions, do you think that the Klonopin and the HC are interacting? Because like I said I would be willing to come off of K if that were the case. I would just like your opinion on this if you have one.
thanks…..

[mylilcappi]

@DrMariano 603 wrote:

AHA.

When things are working well then something suddenly changes, the something else happened.

For example, psychiatrists have often talked about how antidepressants somehow “poop out”. That is, they stop working after a time of working well.

I don’t believe they DO NOT poop out at all. I believe the antidepressant was working the same way all alone. However, something else happened so that the person would again become depressed. For example, perhaps thyroid hormone went down due to aging, perhaps the person’s nutrition went off and they developed B12 deficiency or iron deficiency. In these cases, the antidepressant is doing the same job it has always had. But the person’s body changed. This change is what caused the person to become ill again.

So the question would be, if a person who has adrenal insufficiency and hypothyroidism is doing well for a time on treatment of both conditions, what else happened in the body to cause the person to worsen.

Winter, itself, is a huge stress. Low environmental temperature is a huge physiologic stress. This stress is enough to cause a person to become depressed, anxious, or even manic. And as the weather warms, a person gets better again.

However, outside of the weather, the problem is, what else is missing that would cause a person to topple down and worsen in condition.

For example, with an anxious person, and more stress, the lack of additional adrenal supportive treatments other than hydrocortisone, can worsen the person’s response to a significant stress.

For example, when a person runs out of B-vitamins or other nutrients, then thyroid hormone stops working and a person could worsen. With cortisol onboard, T4 to T3 conversion could improve. But then without adequate nutrition, this actually can be a bad situation since more thyroid hormone can worsen adrenal function or cause further deficiencies of nutrients since they would be used up faster. Thus the cortisol dose may have to be lowered if taking this into account. Thus, nutritional status is very important to assess.

Dr M,
When I was reading other posts, I came across where you said about the heart jumping around like a ball or something similar to that. That is what my heart is doing now, and I know why. I think. My thyroid med is not getting into my cells. I had an ultrasound, EKG, and wore a heart monitor for 24 hours.. Came back normal.. But I feel like I’m on a trampoline when I am laying down.. He prescribed Toprol..
I tried to explain it was my thyroid, but he would not listen..

[mylilcappi]

Yeah I read that on the other board HAN.. But someone came back and stated that you can’t do that without a doctor’s orders.. Don’t think my doctor would do that.. I will suggest it, but that was a response on NT board. I even went to the website..

[mylilcappi]

@hardasnails1973 608 wrote:

Many people get HC from over seas and self administered it with out Dr supervision. I had one client from over seas when verified through saliva, blood, and urine that the HC he was using was fake. I suggested that he take the HC one hour before the cortisol am draw to see if it was going to spike to normal range. The results were surprising to him, but to myself it would it make most logical sense. The clients salvia, blood, urine test were border line Addison’s as his levels were barely registering. I suggested that he goto the nearest endocronologist to get properly evaluated. If you are using over seas meds or even generic HC it may not be suitable for your body. I have had several people you were given generic HC when cortef was called in by the Dr. When they switched to cortef they started to feel better. For some people generic meds just do not work and can end up making people worse.

Hi HAN,
I would be scared to death to order meds from over seas. I never do anything without consulting a doctor.. I am afraid to self medicate. Mine was cortef…. I know some people have to, because doctors won’t cooperate. I hope I never have to. Having a hard time with doctors however….
thanks…

[mylilcappi]

I am a woman if you are referring to me. LOL..

I had my DHEA tested on it and off it.. It is not fine according to labs. Mine came back high.

[mylilcappi]

@DrMariano 603 wrote:

AHA.

When things are working well then something suddenly changes, the something else happened.

For example, psychiatrists have often talked about how antidepressants somehow “poop out”. That is, they stop working after a time of working well.

I don’t believe they DO NOT poop out at all. I believe the antidepressant was working the same way all alone. However, something else happened so that the person would again become depressed. For example, perhaps thyroid hormone went down due to aging, perhaps the person’s nutrition went off and they developed B12 deficiency or iron deficiency. In these cases, the antidepressant is doing the same job it has always had. But the person’s body changed. This change is what caused the person to become ill again.

So the question would be, if a person who has adrenal insufficiency and hypothyroidism is doing well for a time on treatment of both conditions, what else happened in the body to cause the person to worsen.

Winter, itself, is a huge stress. Low environmental temperature is a huge physiologic stress. This stress is enough to cause a person to become depressed, anxious, or even manic. And as the weather warms, a person gets better again.

However, outside of the weather, the problem is, what else is missing that would cause a person to topple down and worsen in condition.

For example, with an anxious person, and more stress, the lack of additional adrenal supportive treatments other than hydrocortisone, can worsen the person’s response to a significant stress.

For example, when a person runs out of B-vitamins or other nutrients, then thyroid hormone stops working and a person could worsen. With cortisol onboard, T4 to T3 conversion could improve. But then without adequate nutrition, this actually can be a bad situation since more thyroid hormone can worsen adrenal function or cause further deficiencies of nutrients since they would be used up faster. Thus the cortisol dose may have to be lowered if taking this into account. Thus, nutritional status is very important to assess.

Thanks you Dr. M,
Nothing changed that drasctically that could make me react this way to HC. I’m speaking of nutrition here.. My diet is very healthy. consistently.. I made that effort last October and have stuck with it. absolutely no processed foods. I eat at home everynight.
So, my main question is do you think thata benzodiazepine would interfere with HC?
If I could only find clinical evidence anywhere, I would be willing to detox off that med.
However, I just don’t know. I have researched this and cannot come up with anything.
Thanks again.

[mylilcappi]

Also I am very interested in many topics that include the nervous system…

How is the world would I go about seeing if my nervous system needs attention.. What kinds of tests, what kinds of doctors? As you can probably tell, I’m desperate..

so you don’t think the klonopin interfered with the HC enough to give me those serious side effects.. especially my MIND.

thanks again…………

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