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@DrMariano 3245 wrote:
I can’t apply information to you specifically, since I haven’t examined you.
What other medications are you referring to?
Some antibiotics have anti-inflammatory effects independent of their antibiotic effects. Some even have antidepressant effects – such as monoamine oxidase inhibition – that is independent of their antibiotic effects. These other mechanisms of actions may not be well documented because they may not be tested for. There are a lot of holes in the fund of information in science since not everything can be tested.
If the anti-inflammatory effects affect thyroid metabolism positively, then thyroid function can improve independently of intestinal absorption, independently of gut infection or non-infection.
Thus, one can’t totally speculate on whether or not a bacterial kill off is occurring with antibiotic treatment unless there is proof it occurred, given other mechanisms of action that antibiotics can have.
I wonder if the discomfort from a hypothesized bacterial kill off may be instead occur as a result of a direct anti-inflammatory effect of an antibiotic, which then improves thyroid metabolism, which then leads, in some cases, to excess thyroid hormone signaling, which then can overactivate the immune system, triggering stress and sickness behaviors. The situation is complicated with the interactions involved.
Dr. M,
I’ve taking my temperature more often since taking antibiotics for my gut and think I maybe absorbing my thyroid meds better. Every day I wake up and take my temp prior to antibiotic treatment, and it was always high 95’s to low 96’s. Now after 5 days of treatment my morning temp is high 96’s in the morning and 98.6 in the afternoon. This was today’s stats, but who knows if it’s going to be consistent. Should my morning temp also be at in around 98.6 as well?@DrMariano 3241 wrote:
Tamoxifen, as a weak estrogen, blocks estrogen signaling in the brain, causing the brain to release more Luteinzing Hormone to stimulate estrogen production by stimulating testesterone and aromatase production from the testes.
Grapefruit contains substances that block the effect of enzyme cytochrome P-450 3A4 (CYP-3A4), which is the major enzyme that breaks down the numerous estrogens and other medications. Blocking CYP-3A4 can cause the affected medications to build up to sometimes toxic doses. Estrogens can accumulate when CYP-3A4 is blocked. High estrogen levels can weaken testosterone signaling.
Medications, such as Tegretol and St. John’s Wort, which stimulate CYP-3A4 production weaken the effects of numerous other medications and hormones. In particular, they weaken the effects of birth control pills, increasing the risk for pregnancy – with the further risk of birth defects when pregnant on birth control pills.
Do you think since I have gut inflammation problems that maybe my intestine were not absorbing my thyroid meds? Every morning I had been taking my temperature and it was always 95’s-96s, but after a few days of antibiotics and other meds for this issue, I took my temperature today and it was around 97.4?
Could my intestine be absorbing my thyroid meds better?
@DrMariano 2985 wrote:
Generally, when problems are occurring in treatment, there are problems which need to be first addressed.
When it comes to obtaining mental health and physical health, there are a hierarchy of areas where problems have to be first addressed:
1. Nutrition
2. Immune system problems
3. Nervous system problems (this includes brain, psychological and social issues)
4. Adrenal signaling regulation
5. Thyroid signaling
6. Testosterone signaling
7. Estrogen signaling
8. Growth HormoneIf problems at one level are addressed prematurely, then the foundation for the treatment may not have been set to either self-correct or minimize adverse effects.
Optimizing nutrition often involves obtaining nutrient testing to see what one is actually obtaining from one’s diet. Modern diets can be seriously deficient despite appearances.
A good starting point for nutrition is the book “Nourishing Traditions” by Sally Fallon. This is based on the work of Weston Price DDS who found that traditional diets are very nutrient dense (up to 10 times more) and that traditional diets leads to greater physical health than modern diets.
Physical health needs to be optimized if one is to achieve mental health. Mental health includes sexual function, emotional function, cognitive function, relationship and social functioning, etc. etc.
Dr. M,
Does neurotransmitters play a role in sense of smell? The one thing I’ve noticed in the past when my mood was little better years ago there would be a distinct smell in the air outside especially during the summer. The smell of grass, tree, leaves would stimulate endorphins. Summer would make me happy, but for many years now I can’t smell that. I know this sound strange, but it’s true for me at least and can’t seem to figure it out. I haven’t lost my sense of smell completely, but it’s not the same. I also have been experiencing ringing in my ears for few years now. I though fixing thyroid was supposed to help, but it didn’t and I’m not sure how to fix it.Going back to trt for a sec. I’ve had the most difficult time in controlling estrogen while on trt 3 different times. Not sure why I have no luck, but how does one keep there estrogen in the right “range” for a long time? I would either go too low or not low enough or hit the zone, but would not stay there. I’ve read many horror stories on people who quit trt because libido was always inconsistent which is why I quit.
@DrMariano 2977 wrote:
Are you saying is that until recently, you have been on a poor diet?
Diabetes occurs most often in those with poor diets.
It is difficult to lose weight when one has insomnia. The underlying causes of insomnia predispose someone to weight gain.
Why did you stop testosterone replacement? Optimizing testosterone is one way of helping reduce insulin resistance and reducing body fat in men.
Generally, when people have problems losing weight, there are problems which are not being addressed.
Nutrition is probably the biggest contributor to obesity since that is what has worsened since the beginning of the 1900s. The general trend is to have less nutrition per calorie eaten. Traditional diets can have up to 10 times more nutrition per calorie than modern diets. The more nutrition per calorie, fewer calories one needs to feel satisfied.
My diet up nutil a few months ago was ok. I would go off track sometimes especially working long days and coming home tired I would eat something probabaly not great for my diet, but this wasn’t every day. For 4 months now I’ve been more strict with my diet so it’s gotten better.
I went on TRT 3 times over a period of 5 years. My libido was completely dead the whole time. Only one time my libido turned on for about 6 days and that was it. The first time I went on TRT I would take arimidex and it would make me very sharp and focused, but that was impossible to sustain. The next 2 times I went on trt, taking arimidex never got me back to that state which tells me something else was wrong. I lost my fiancee of 6 years because we never saw the light at the end of the tunnel with trt. I would of stayed on it if it worked. I felt the same on it as I do off of it and the only time I fell like a million bucks was that one time that my libido kicked in. It was very strong libido surge for 6 days and I felt sharp and focued. My shbg is around 14 so I’d have to get my e2 very low, but staying there is hard because my e2 waas consistantly at 30 and t-levels at 800-850 while on trt.
I’ve had normal levels of testosterone in the past in the 500’s range, but when it dropped into the 300 is when I went on trt. Even when they were normal my libido was very weak, energy was low and was very lazy, socially shy, and brain fog. I knew something was wrong growing up and even during high school. I stopped playing sports freshman year becuase my joint fell weak like they were going to break. It’s been 6 years of treatments and 3 doctors, but no one has been able to figure out or fix what’s wrong with me. It’s really impacted my relationship and my career job.
Another issue is I was losing so much hair on T-cream and then t-shots. I stopped TRT 8 months ago and I’m still losing so much hair and don’t know why.
I knew insomnia was contributing to my weight gain, but everytime I address this with my doc they didn’t know why I was having insomnia unitl I figured it out for my self. now I know and barely have any sugar anymore.
@Geno 2964 wrote:
loopey107, I have many similar medical conditions as you. I am 46 yr old male, on TRT,Thyroid,DHEA,Hydrocortisone, SSRI and Dexedrine. I supplement my diet and I try to eat a nutritiously as I can afford. In the past five years or so, my IGF-1 results have ranged from 115 – 167. I believe HGH can and will help me overall, especially the improved “Quality of Life” and “Better sense of well being” as a majority of the detailed studies that I have researched have seemed to emphasize as a common result from HGH replacement, specifically for AGHD, Adult Growth Hormone Deficiency. Too many studies to post here, plus I don’t have them handy right now. Anyway, Dr. Mariano’s answers to your questions were very informative. I like it when someone else who has a condition similar to mine posts a question and get’s replies back that help me and others to learn 😀 In one of Dr. Mariano’s replies to you, he touched on the subject of “External Stressors” (e.g. work, relationships, psychological problems,social issues, etc..) and I would like to add to this subject from my own stessors in this regard that I did not see in any of your questions. As for me, I have had chronic sleep issues for many years (Insomnia, early waking & inability to go back to sleep at 3 a.m.) I do not have a weight problem and I am not obese (6’2″ 220lbs) but I do believe that many years of “Sleep Problems” may have contributed to my low levels of IGF-1. As you may know, GH is released in spurts during a certain stage in the sleep cycle. I don’t believe I have slept a complete 8 hours in years. Anyway, this is a “STRESSOR” of mine too. I also “Internalize” and worry excessively on HOW, WHEN, and IF, I will get better and feel and function somewhat “Normal” again. On a daily basis, I have “Obsessive Thoughts” on my health, why I have all these conditions, when and if I will get better, and my focus on a daily basis is about 90% on trying to figure out “HOW THE HELL I CAN GET AND FEEL BETTER !” I am very fortunate to have Dr. Mariano on my side to help me. If you can somehow try to figure out a way to become one of Dr. Mariano’s patients, you would be alot better off. He is an awesome, highly educated, medical mastermind, if you ask me. I had gull bladder surgery in April, so my mind and body are still stressed, thus delaying my improvement from multiple hormone deficiencies, HPA dysregulation, Major Depression, (Dysthmia/Anhedonia like condition), Chronic Fatigue. etc.. The “Stress” alone during the waiting process to heal and recuperate (Especially from Adrenal issues) can delay recovery as well. It seems to me that your weight issue may be causing you a lot of stress ? Anyway, good luck with reaching your goals, glad you aked the questions that you did ask as they can and do help others on this site. Geno
I’ve had sleep issues on and of for many years. Only recently I figured what may of caused this issue which was eating at night food that spike blood sugar. During tough long days at work I’d come home and eat late a peanut butter and jelly sandwich or anything that may have with sugar. Now I didn’t choose to eat something because it had sugar, but many things you find to eat will have some. I could fall asleep only until 2am and just wake up for the rest of the night. As soon as I changed my diet and only eat some protein like turkey or chicken at night is when I started to be able to sleep again. I actually have been able to have dreams as of late which it’s been a long time of not being able to do that.
My weight only concerns me because I have insulin resistance, but I need to be and a ssri and don’t want to gain weight. I should be 155-160lbs, but I’m at 175-180lbs. So I’m not grossly over weight, but my issue is I can seem to lose weight even with diet and cardio.
I can definitely say that I’ve gotten more insightful answers to my questions from
Dr. Mariano on this thread alone that I have in 6 months of posting on other boards. Dr. Mariano has been very helpful in answering questions that no one else would help me with else where so I’m very thankful for that.@DrMariano 2951 wrote:
Weight gain has multiple possible causes which can all be present in a person. Thus, hypothyroidism can be one of many causes a person may have. Each cause needs to be identified and addressed in order for a person to lose weight. Some causes include:
1. Hypothyroidism
2. Poor nutrition (e.g. low nutrient density, low animal fat content, excess carbohydrates, food choices, etc.)
3. Stress – both external (e.g. work, relationship, psychological problems, social issues, etc.) and internal (e.g. metabolic problems, infection, nutritional deficiencies, etc.).
4. Insulin Resistance (which has multiple causes including hypothyroidism, stress, poor nutrition, low testosterone, suboptimal lipid metabolism, etc.)
5. Excessive Caloric Intake compared to caloric needs (e.g. lack of exercise or physical activity, etc.)
6. Genetic factors (including hypothyroidism, etc.)
7. Etc.From a societal point of view, much of obesity is due to poor nutrition. This tends to follow socioeconomic factors – with poor people tending to be obese since they are forced to eat more affordable but non-nutrient dense foods. But the lack of nutritional density can be applied to various people in regard to food choices. And this contributes to obesity.
One alternative way of looking at obesity is that people will eat in excess of their caloric needs in an attempt to meet nutrient deficiencies at the cellular level. These nutrient deficiencies will drive behavior to find a solution. If society provides non-nutrient dense food choices, then caloric intake will inevitably be in excess. Historically, societies have moved away from nutrient-dense traditional foods for less nutrient-dense modern foods for various reasons, at its peril.
There are various causes for lipid abnormalities and various solutions including improving nutrition, exercise, medications and supplements.
—
Shyness can be a person’s temperament – a trait one is born with, a biological trait. It can be modified by one’s experiences and choices and needs. The brain is born with certain biological predispositions – such as shyness. But it also reprograms and constantly restructures and modifies itself depending on the solutions it develops to the problems it experiences. For example, if one desires to modify one’s brain structure to modify the trait of shyness because of social pressure or shame (the emotion caused by one not meeting one’s own expectations or rules), then one will find a solution (e.g. taking public speaking classes, engaging in group therapy, etc.).
The brain will change as much as it can if it is forced to find a solution in order to survive. It can rewire itself to a certain extent in order to do so. It is like learning a language. If one was dropped into a foreign country, one will have to learn the language to a certain extent in order to survive (e.g. to get food, clothing, shelter, etc.) no matter how old one is. If one does not set the condition that change is necessary for survival then change may not be achieved because it is not the solution to a problem. Thus with shyness, if avoidance is an available solution, then one may not change. But if avoidance is not a possible solution, then one would be forced to change.
Provigil or an SSRI may either help OR worsen OR cause no change depending on the underlying biological conditions underlying a social disorder or leg shaking. Determining the underlying biological condition is important to help determine what direction one may go when doing an intervention.
Thanks for all the insightful information Dr Mariano. Just have another question.
Can Provigil with SSRI help with my issue of feeling emotionally flat since I can’t feel love emotions?@DrMariano 2940 wrote:
Provigil may increase sex drive. Stimulants have long been used to increase sex drive. However, which direction is goes depends on the sum of the signaling and metabolic changes it triggers. By increasing norepinephrine in a person who already has excessive norepinephrine signaling, it may also just tip the balance toward impaired sex drive.
Being overweight or obese and having insulin resistance places one in a vicious circle or positive feedback loop. In obesity, the fat cells send signals to the body which lead to increased stress/norepinephrine signaling. The increased norepinephrine signaling causes insulin resistance, which leads to an increase in insulin signaling. Insulin is a signal that triggers fat storage.
Breaking this loop is difficult. Insulin resistance usually has many simultaneous underlying causes. Each has to be searched for and addressed. Suboptimal thyroid hormone signaling can lead to insulin resistance. Multiple nutrient deficiencies can lead to insulin resistance. The multiple causes of stress/norepinephrine signaling can lead to insulin resistance. Suboptimal testosterone signaling can lead to insulin resistance. Nervous system dysfunction can lead to insulin resistance. Immune system problems can lead to insulin resistance. etc. etc. etc.
Despite the subphysiologic dose of 20 mg a day, exogenous hydrocortisone – which is working against the factors that lead to adrenal dysregulation and lowered adrenal cortex signaling – can itself contribute to insulin resistance within that context. This is why it is important to search for and address the causes of adrenal dysregulation instead of settling for adrenal signaling support via hormone replacement therapy.
Often, when someone tells me they have a good diet, it turns out, after analyzing their diet, it is a poor diet. Most often, the diet is nutrient poor – missing several nutrients. One has to be care even with a low carb diet, for example. Tryptophan, the precursor to serotonin, which is one of the primary control signals for norepinephrine – i.e. it is one of the primary antistress signals, is not well absorbed without carbohydrates. One hallmark of a good diet is that it is nutrient dense. This reduces the need for a high calorie diet to obtain crucial nutrients. One does not need to eat much when the diet is nutrient dense.
One reason it may be difficult to reduce weight is that weight gain is a defensive response to stress. As I am fond of saying, “Stress causes weight gain” – predictably. Fat is stored energy. Muscle can be also considered stored energy. This is one reason I like to keep track of a patient’s weight. When weight goes up, generally, the patient has had a stressful period of time. In my experience, in only perhaps 1 in 9 people does stress cause weight loss. In the others have weight gain, instead. The presence of excessive stress/norepinephrine signaling indicates something continues to be wrong either externally (e.g. environmental stress, relationship stress, job stress, etc.) or internally to the body. It is important to target the internal causes of stress (e.g. infection, nutrient deficiency, hormone deficiency, etc. etc.).
I though when I got on thyroid medication for hypothyroidism that I would of lost weight or had an easier time, but that was not the case. obvious something is out of whack and not normal. I also know that my lipids are messed up and I’m pretty sure I have high
triglycerides, but sure what causes it or how to fix it.I’ve also grown up with a bit of a social disorder when I’m around groups of people I speak only when I have to and trying to be an out going person and talkative with people I meet or don’t know is impossible. I am talkative with people I’m comfortable with, but more reserved around new people. My doc had put me on adderral to help that, but it made me feel high and made it worse to talk to people. I guess the brain fog makes it harder to process quick thoughts and makes me less likely to be talkative. I also constantly have to shake my legs when sitting down. Been like that since childhood and would need to pace around if I was standing.
Can Provigil and a SSRI help that social disorder and leg shaking?
@DrMariano 2935 wrote:
To improve signaling, one has to improve metabolism and nutrition. This, for example, helps provide the precursors for the production of dopamine and serotonin, and helps the processes that form them. Dopamine production and other signals are dependent on optimal iron levels.
Increasing serotonin signaling is fairly easy and commonly done: Serotonin reuptake inhibitors increase the duration of serotonin signaling. Some people benefit from taking the precursor for serotonin – tryptophan or 5HTP. Increasing serotonin will reduce dopamine production, however. Thus a balance needs to be struck.
Increasing dopaming signaling in the behavioral areas can be done using dopamine agonists. When stimulants are too strong, a much weaker one such as Provigil can be employed, which doesn’t increase norepinephrine excessively.
Drive/motivation needs a combination of dopamine and norepinephrine. Dopamine alone can make a person sleepy or dizzy or constipated, etc. , particularly in excess.
Dopamine signaling, however, is reduced when there is excessive stress and inflammatory signaling in the body. The causes for these signaling problems have to be found and addressed in order to restore a feeling of wellness.
Can Provigil increase sex drive even while on SSRI? Another issue is that I need SSRI for serotonin, but can’t afford to gain weight because of my insulin resistance.
How does some one like me with insulin resistance get around the weight gain on SSRI especially if I have a hard time losing weight?Even though I’m on HC tablets at 20mg per with dhea cream I still seem stressed not as much as before doing the dhea so it did help. I also diet very well with low carb diet and low glycimic foods, but continue to have insulin resistance issues and can’t lose weight not matter how much cardio I do or how well I eat. I though when I got on thyroid meds that I would lose weight, but I did not. Motivation is a big issue for me because of low dopamine.
@DrMariano 2920 wrote:
Stimulants, such as Adderall, increase both dopamine signaling and norepinephrine signaling. The norepinephrine signaling may then increase inflammatory cytokine signaling, which then leads to dysregulation of the adrenal glands. One cannot separate the desired dopamine signal increase from the undesired norepinephrine increase when using a stimulant. Excessive norepinephrine signaling will reduce growth hormone production.
Improving nutrition can improve neurotransmitter signaling and growth hormone production. For example, optimizing iron (neither too high nor too low) helps reduce the need for norepinephrine signaling to improve metabolism and improves dopamine signaling. Some growth hormone secretagogues improve certain amino acids to improve growth hormone production. For example, Secretropin, a prescription growth hormone secretagogue attempts to use nutrients to improve growth hormone production – with research to back it up.
Optimizing endocrine and immune function can also do the same.
Certain medications can improve neurotransmitter signaling to help improve growth hormone production.
How can one really improve low dopamine and serotonin? What medications that are not stimulants that can help whether it’s one medicine that does both or a combo?
Both are low for me and even though my cortisol dose works for me I still don’t have any energy or motivation. The last time I had energy and could really work out was when my doc had me on adderall which fatigued me too much. Concerta and wellbutrin didn’t fatigue me that I can remember. I need to optimized both for sure. I grew up having an issue of not being able to feel love emotions. I feel very flat emotionally and never feel euphoric at any time that I’m happy.
@DrMariano 2905 wrote:
The Endocrine Society has a useful guideline for growth hormone deficiency diagnosis and treatment.
Quest Diagnostrics Labs has the adult range for IGF-1 (an indirect measure of growth hormone) as:
Males 19-30 y.o. : 126 to 382 ng/mL
Females 19-30 y.o.: 138-410 ng/mLWhere a practitioner draws the line on where growth hormone deficiency lies depends on the practitioner. Since many anti-aging doctors aim to optimize levels, for example, their cut-off point may be higher than others for what is deficient. They may aim for a level close to 400 ng/mL. Per Endocrine Society guidelines, even a normal IGF-1 does not preclude growth hormone deficiency, though additional testing needs to be done in this case, to verify a growth hormone deficiency. There is a lot of clinical consideration to the diagnosis.
Aside from IGF-1, a 24-hour urine growth hormone test can be done as well as individual blood tests for growth hormone, and stimulation tests for growth hormone. How much testing needs to be done depends on the practitioner.
IGF-1, which does the bulk of growth hormone’s actions, is also influenced by many factors. This includes signals such as testosterone, thyroid hormone, insulin, DHEA, cortisol, dopamine, norepinephrine etc. etc. Signaling problems, metabolic problems, and nutritional problems can all lower growth hormone production. Optimizing these other signaling systems, metabolism and nutrition will help increase growth hormone’s effectiveness, and IGF-1. Ultimately, optimizing these systems first both increases one’s own growth hormone production and reduces the dose for growth hormone needed when treatment is decided, if it is needed at all.
Thus, why should a person be treated with growth hormone if they are still hypogonadal, hypothyroid, have insulin resistance or diabetes, immune problems, have poor nutrition or nervous system/mental health problems? These will reduce growth hormone production. Many symptoms attributed to low growth hormone (aside from impaired skeletal growth – which is too late to be treated once adult) may instead represent problems in other systems which influence growth hormone. These problems ideally should be addressed first before growth hormone treatment.
Generally, growth hormone should be the last treatment considered. The other signaling system, metabolism and nutrition may need to be first optimized. This would help minimize problems from adding growth hormone itself.
Side effects of growth hormone may include: fatigue, joint stiffness, water retention, joint pain, muscle pain, carpal tunnel syndrome, hypertension, insulin resistance and Diabetes type 2, up to 30% reduction in adrenal function (including lower cortisol, progesterone, testosterone, estradiol, DHEA production), lower thyroid hormone levels. Optimizing the affected systems may help buffer and reduce side effects of treatment.
Many practitioners prefer to add growth hormone at the start since the incidence of side effects is relatively low. But I usually get to see the patients when growth hormone did not work and instead worsened their condition since the other systems were not first optimized. In these patients, I may have to remove growth hormone treatment and address the other underlying problems that cause their illness.
How does someone optimize both neurotransmitters in order to get GH levels up?
I have low dopamine (constantly spaced out) and low serotonin. Dopamine meds cause adrenal fatigue so how does someone get around that? I took adderall and felt like I was high and it beat up my adrenals.@marsaday1971 2421 wrote:
I am working through getting well too.
I am taking 20mg HC and 2 grains thyroid-s.
i increased the thyroid last week and had a great week, but now feeling a bit low /hypo again. It is really weird when i make a change in medication as i always feel great for a week. Placebo for sure, but temps did increase, so maybe i just need more thyroid hormone.
i may increase again today as it has been 7 days since my last increase.
Thyroid is just one of those things that takes some tweaking for a bit before getting it to the sweet spot.
On my last lab my t-3 did get better, but I’m still tweaking. I can tell because my ears ring from the minute I wake up and until I go to bed. My hypothyroid is definitely getting close to being all set very soon. I’ve been hypothyroid for many years and never knew that the symptoms I was having was related to thyroid.
my current t-3 lab:
t3 = 326 (230-420 pg/dL)@MetalMX 2384 wrote:
Yeah i know you just have to find your individualised dosages to feel good. God its tough hanging in their… has been like this for 3 years, last year was most severe. But since i feel much improved then before then it has been much easier to cope. Just want to get back to working and more normal routine since i have been unemployed and unable to study for a year straight due to issues.
So you are on armour and T3? What dosages? and what dosage of HC are you on?
I’m on 1 grain of armour and 10mcgs of T-3 along with 20mg of cortef. This does work well for me, but it does take time to get the dosing correct. What may work for me may not for you. Keep track of your symptoms as your doctor changes your dosing around based on your lab results and the symptoms that you have until you feel better. For me cortef didn’t really start working well until I got to 20mg dose. Now I don’t wake up as fatigued as I used to. I never wanted to get out of bed in the morning because my cortisol levels sucked in the morning, but now it’s not that bad anymore. I did have a few really tough months until I got my adrenals in check. Definitely feeling better with cortef at 20mg.
My thyroid is doing much better now, but still tweaking the T-3 dosing very slowly and noticing improvements. Ears still ringing and motivation and energy is still down, but I’m not fatigued or sluggish anymore which I’m happy about. You don’t want to over do it so you don’t go hyper.
@MetalMX 2381 wrote:
One thing i frequently experience above anything else is difficulty breathing/air hunger and tingling in my throat like something is crawling in their. This is the worst symptom ever, along with all this other crap. Oh and the waking up 3 times a night right after falling asleep for the past 4 years.
Has anyone had this symptom on this forum as well who had adrenal problems?
It would be good if someone could post about their symptoms/life issues due to adrenals and how symptoms resolved after HC treatment or getting their adrenals in good shape.
I have both adrenal and thyroid issues and have the same symptoms as you do. I would wake up 3-4 times per night every damn night when my thyroid was off. As soon as I got my thyroid in check I slept like a baby after years of not know what was causing it. I was hypothyroid and this can cause it for sure. I recently went hyper and these symptoms came back then I lowered my thyroid dose and went hypo again and guess what symptoms came right back…..many nights waking up all night again!! I’ve increased my t-3 a bit and kept my armour the same and now starting to sleep ok. I’m not completely there yet, but gotten better sleep. If your adrenals are out of whack this could be an issue too.
I had high level of cortisol at night during sleep and low during the day. I started with phosphatidylserine and it worked good enough until I treated adrenals with cortef. Fixing thyroid and adrenals help me a lot. Just keep in mind that you may experience this for sometime until you’ve reached the correct doses for thyroid and adrenals if thats your issues according to your labs. It does take time to figure the correct dose and taking many labs, but try to hang in there.
One thing that I have noticed is that my ears are ringing all day long from the minute I wake up unitl I go to bed. This happened to me in the past when I took wellbutrin at a high dose and it drove me crazy.
It’s happening now and for sometime, but not sure if its related to high norepinephrine?
So just to get this straight if I somehow can lower my norepinephrine then my dopamine will increase?
Could this be why I may have low dopamine issues?
I’ve had symptoms of high norepinephrine (serious premature ejaculation, low dopamine) since at least high school which was over 12-13 years ago.
Is there any medication that treats this?
