[golf17331]

I think the real question is whether or not this is a treatable or reversible situation, hopefully Dr. Mariano will post his information related to this topic soon.

[golf17331]

Thank you for taking the time to formulate a response to this, Doctor, I look forward to reading what you have to write. I also am curious if you consider this a treatable condition.

[golf17331]

As I had stated in my other post, it is also common to find very low 3alpha-androstanediol glucuronide in patients with these symptoms after taking finasteride even if they have normal testosterone or DHT levels. Does this tie into other endocrine functions such as thyroid or the adrenal systems or is this due to some type of enzyme deficiency?

Since many people are now searching for the mechanism in which these long term side effects occur (there is clinical study about long term finasteride side effects, and another neuroendocrinologist named alan jacobs is now blogging about it) What do you believe, Dr. Mariano, is causing long term side effects after the drugs discontinuation?

Alan Jacobs’ blog is here, btw.
http://blog.alanjacobsmd.com/alan-jacobs-mds-blog/2010/06/index.html

[golf17331]

I Also do not to wish to steal this thread but to want to expand upon it:

one of the additional problems that many people whom experience long term issues with finasteride use are very low (under the bottom range) of serum level of 3alpha-androstanediol glucuronide which is the primary metabolite of DHT, and, correct me if i am wrong, also a neurosteroid and general indicator of overal androgenism. This is under range even in some with above-range DHT levels. In addition, a recent trend has emerged with some people having above-range reverse t3 levels.

Do you have any idea why this may occur even after a short period of finasteride usage, 4-6 weeks for example?

Thank you sincerely.

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