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@MetalMX 1380 wrote:
My question is simply will transdermal DHEA improve IGF-1 signaling?
If so to what degree.
IGF-1 production is determine by multiple signals:
- Growth Hormone
- Thyroid Hormone
- Testosterone
- DHEA
- Other Androgens
- Estrogens
- Dopamine
- Norepinephrine
- Serotonin
- GABA
- etc.
How much of IGF-1 is determine by any individual factor depends on the individual. Individual before and after measurements would be necessary to determine which direction a person may head.
In regard to DHEA specifically, DHEA can also metabolize to testosterone and various estrogens. These may have opposite effects on IGF-1. Thus, in a person who metabolizes DHEA primarily to estrogens, IGF-1 may be reduced by excessive DHEA. In a person who metabolises DHEA primarily to testosterone, IGF-1 may increase with the supplementation of DHEA.
@DrMariano 1399 wrote:
IGF-1 production is determine by multiple signals:
- Growth Hormone
- Thyroid Hormone
- Testosterone
- DHEA
- Other Androgens
- Estrogens
- Dopamine
- Norepinephrine
- Serotonin
- GABA
- etc.
How much of IGF-1 is determine by any individual factor depends on the individual. Individual before and after measurements would be necessary to determine which direction a person may head.
In regard to DHEA specifically, DHEA can also metabolize to testosterone and various estrogens. These may have opposite effects on IGF-1. Thus, in a person who metabolizes DHEA primarily to estrogens, IGF-1 may be reduced by excessive DHEA. In a person who metabolises DHEA primarily to testosterone, IGF-1 may increase with the supplementation of DHEA.
What if you support conversion of bad estrogens to good estrogens with something such as I3C (Indole 3 Carbinol) while using DHEA would high enough doses of I3C guarantee you keeping bad estrogens down and getting the DHEA converted into testosterone and subsequently IGF-1?
@MetalMX 1409 wrote:
What if you support conversion of bad estrogens to good estrogens with something such as I3C (Indole 3 Carbinol) while using DHEA would high enough doses of I3C guarantee you keeping bad estrogens down and getting the DHEA converted into testosterone and subsequently IGF-1?
This may not necessarily work but is perhaps worth a try to see if this helps increase IGF-1 production.
By “Bad” estrogen, one is referring to estrogens that promote growth of cells – the proliferative estrogens – as opposed to the “Good” estrogens which do not promote cellular proliferation and thus are less likely to cause cancer.
But this distinction is different from the way estrogens can block IGF-1 production by the liver in response to growth hormone or how estrogens can reduce thyroid hormone activity by stimulating thyroid binding globulin production from the liver. These are non-proliferative actions of estrogen. Thus both “good” and “bad” estrogens can participate.
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