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I have a major reverse T3 problem. I have tried Cytomel numerous times and it makes me feel better briefly but then I get “hyper” symptoms without actually being hyper.
Even on 25mcg per day (dosed all at once or 3x per day) my heart rate will jump into 100+ range and I have severe fatigue and “shakiness” along with orthostatic hypotension.
I’ve tried with up to 40mg HC daily and have also tried a large dose of medrol+florinef but it doesn’t do anything to resolve these symptoms.
Thoughts?
Ferritin, Vit D, B12 all good. Last electrolytes Na 142, K 4.1
Did you slowly ramp up the HC at least 2 weeks *before* starting any T3? Did you then slowly ramp up the T3 dose or start right away on 25mcg?
@leanguy 2572 wrote:
Did you slowly ramp up the HC at least 2 weeks *before* starting any T3? Did you then slowly ramp up the T3 dose or start right away on 25mcg?
I’ve been on HC for nearly a year now. The T3 was ramped up over weeks starting at 2.5 twice per day. I started noticing these symptoms once I hit 10mcg per day but they just got worse and worse. I can’t seem to tolerate it at all.
Maybe you just don’t need that much.
What are your T3 / Free T3 levels when you take 5mcg , 7.5mcg, 10mcg?
Did you get Reverse T3 retested once you were on T3?
Some people have a hard time with it.
What are your T4 / Free T4 levels?
Are you taking any nutritional supplements – particularly Iodine and Selenium to help with Reverse T3?
@Figuring 2574 wrote:
I’ve been on HC for nearly a year now. The T3 was ramped up over weeks starting at 2.5 twice per day. I started noticing these symptoms once I hit 10mcg per day but they just got worse and worse. I can’t seem to tolerate it at all.
@wondering 2575 wrote:
Maybe you just don’t need that much.
What are your T3 / Free T3 levels when you take 5mcg , 7.5mcg, 10mcg?
Did you get Reverse T3 retested once you were on T3?
Some people have a hard time with it.
What are your T4 / Free T4 levels?
Are you taking any nutritional supplements – particularly Iodine and Selenium to help with Reverse T3?
My last results before my latest attempt were:
FT4: 1.57 (.61-1.76)
FT3: 3.0 (2.3-4.2)
rT3: 507 (90-350)So then I worked up to 25mcg per day of cytomel. I was telling my doctor that I was feeling my above listed symptoms so he pulled me off the cytomel and had me go in for labs thinking I was hyper.
The morning I went in for labs I was a wreck. Shaking, dizzy, weak. It was warm out and I felt like I was going to collapse in the heat. I was certain I was hyper…results show no such thing.
FT4: .90
FT3: 3.2
rT3: 270Not even close to being hyper…I had these symptoms for days after discontinuing the cytomel.
It’s like my body cannot handle faster metabolic states. Something is seriously wrong with me but I can’t find it.
I take 300mcg of Selenium daily and iodine as well (1-2 iodoral). I’m not aware of iodine’s effect on rT3 though.
I’m not certain what’s wrong with me.
All i can think of is sometimes iodoral can cause worsening of hypo symptoms since 1 drop contains 6mg or so of iodine it just aggravates the autoimmune attack on the thyroid if you have hashimoto’s thyroiditis.
Are these you’re only symptoms or are their others and when did they start exactly how long ago? did you change any meds or supplements etc…
Those are low cortisol symptoms. The half-life of HC is anywhere from 1-8 hours. If your dosing HC 4x daily and it lasts 6-8 hours in your body, you should be fine. Others metabolize it far too quickly to gain any benefit (myself included). My guess is you would have to switch to something like medrol (methylprednisolone) which has a much longer half-life. 1mg medrol = 5mg HC.
The half-life of T3 is only about 7 hours. So if you stopped taking T3 the day before your labs, then that number is not representative of your T3 levels while on Cytomel.
Are you under stress? That can increase RT3.
Your T4 is obviously low, that can affect how you feel as well. I know I need to be mid-range. Perhaps get on Cytomel for a bit and then add some T4. Your 2nd set of numbers dont look horrible except for the T4.
@Figuring 2577 wrote:
My last results before my latest attempt were:
FT4: 1.57 (.61-1.76)
FT3: 3.0 (2.3-4.2)
rT3: 507 (90-350)So then I worked up to 25mcg per day of cytomel. I was telling my doctor that I was feeling my above listed symptoms so he pulled me off the cytomel and had me go in for labs thinking I was hyper.
The morning I went in for labs I was a wreck. Shaking, dizzy, weak. It was warm out and I felt like I was going to collapse in the heat. I was certain I was hyper…results show no such thing.
FT4: .90
FT3: 3.2
rT3: 270Not even close to being hyper…I had these symptoms for days after discontinuing the cytomel.
It’s like my body cannot handle faster metabolic states. Something is seriously wrong with me but I can’t find it.
I take 300mcg of Selenium daily and iodine as well (1-2 iodoral). I’m not aware of iodine’s effect on rT3 though.
I’m not certain what’s wrong with me.
@Drew 2596 wrote:
Those are low cortisol symptoms. The half-life of HC is anywhere from 1-8 hours. If your dosing HC 4x daily and it lasts 6-8 hours in your body, you should be fine. Others metabolize it far too quickly to gain any benefit (myself included). My guess is you would have to switch to something like medrol (methylprednisolone) which has a much longer half-life. 1mg medrol = 5mg HC.
Hi Drew, if you look at my original post you’ll see that I’ve tried Medrol without result.
I do believe this is adrenal related but I’m wondering if it could perhaps be low aldosterone? I did try florinef before but maybe I need a higher dose or something?
I, unfortunately, have the same problem. I, too have gone as high as 40mg of hc, have since weaned off to adrenal cortex extract and isocort as I had insomnia on hc. I have fixed ferritin, B12, D, and female hormones and STILL can’t tolerate more than 1/2 grain of thyroid med. I have Hashimoto’s and a high TSH (11) last time I checked. I just don’t get it- I’ve also tried other thyroid meds- T4, T3, old Armour, etc. I take Nutrimeds throid now as it’s a bit easier to tolerate. I, too have salt wasting so possibly florinef is the answer, I don’t know. I hate to try florinef and still not be able to tolerate thyroid meds. Also, for some reason, right now my usually low BP is a bit high so don’t really want to add florinef at this time. Grrrr!
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