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It is said to decrease stress hormones (norepinephrine) through inhibition of DBH. Has anyone had experience with this?
@The450Man 1077 wrote:
It is said to decrease stress hormones (norepinephrine) through inhibition of DBH. Has anyone had experience with this?
Here is a useful link: http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-pycnogenol.html
Pycnogenol® is the patented trade name for a water extract of the bark of the French maritime pine ( Pinus pinaster ssp. atlantica ), which is grown in coastal southwest France. Pycnogenol® contains oligomeric proanthocyanidins (OPCs) as well as several other bioflavonoids: catechin, epicatechin, phenolic fruit acids (such as ferulic acid and caffeic acid), and taxifolin. Procyanidins are oligometric catechins found at high concentrations in red wine, grapes, cocoa, cranberries, apples, and some supplements such as Pycnogenol®.
There has been some confusion in the U.S. market regarding OPC products containing Pycnogenol® or grape seed extract (GSE) because one of the generic terms for chemical constituents (“pycnogenols”) is the same as the patented trade name (Pycnogenol®). Some GSE products were formerly erroneously labeled and marketed in the U.S. as containing “pycnogenols.” Although GSE and Pycnogenol® do contain similar chemical constituents (primarily in the OPC fraction), the chemical, pharmacological, and clinical literature on the two products are distinct. The term Pycnogenol® should therefore only be used to refer to the specific proprietary pine bark extract. Scientific literature regarding this product should not be referenced as a basis for the safety or effectiveness of GSE.
It has some evidence for use in Asthma and Chronic Venous Insufficiency. There are other uses noted in the link which have less data supporting its use.
From experience, although I haven’t used this long term, Grape Seed Extract makes me so relax, the first few times, I just couldn’t believe it. I get very mellow and smiling comes naturally.
@chipdouglas 1134 wrote:
From experience, although I haven’t used this long term, Grape Seed Extract makes me so relax, the first few times, I just couldn’t believe it. I get very mellow and smiling comes naturally.
The placebo effect is very strong when it comes to things that can affect mood. It generally can last up to two years.
A double-blind placebo controlled study would be useful to determine if it has an effect independent of placebo.
@DrMariano 1150 wrote:
The placebo effect is very strong when it comes to things that can affect mood. It generally can last up to two years.
A double-blind placebo controlled study would be useful to determine if it has an effect independent of placebo.
I strongly agree. What’s more I’ve only had GSE occasionally. However, this effect I’ve experienced, I clearly didn’t expect. Having said this, I’ve read upon the placebo effect a while ago, and found out it’s very real and powerful. I didn’t know it could last up to two years though.
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