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Since prostate tissue and uterine tissue arise from the same embryonic tissue I find it interesting that docs would say testosterone (DHT actually) is the cause of prostate enlargement and ultimately the cause and proliferative agents of prostate cancers. There does seem to be a link but I find it all very confusing since uterine cancers generally proliferate in the presence of estrogens but I’ve never heard mainstream docs say the same about prostate cancers. They always say in the presence of androgens and estrogens are seldom if ever discussed unless you read about it on forums such as these. Where am I going wrong?
@skywalker45 1442 wrote:
Since prostate tissue and uterine tissue arise from the same embryonic tissue I find it interesting that docs would say testosterone (DHT actually) is the cause of prostate enlargement and ultimately the cause and proliferative agents of prostate cancers. There does seem to be a link but I find it all very confusing since uterine cancers generally proliferate in the presence of estrogens but I’ve never heard mainstream docs say the same about prostate cancers. They always say in the presence of androgens and estrogens are seldom if ever discussed unless you read about it on forums such as these. Where am I going wrong?
Just as an anecdote to my statement and questions above —- Is there any relation or division exactly between a uterus being essentially saturated with estrogen receptors and a prostate being essentially saturated with androgen receptors? Common sense would say this is true from the difference in sexes but yet the argument of estradiol causing prostate enlargement and cell proliferation is intriguing.
This is one of the best links I have found about estrogen and cancer
http://www.cabecahealth.com/PDF%20files/NutrInfluencesEstrogen.pdfESTROGEN PRODUCTION
The term “estrogen” is used to collectively describe the
female hormones, the most potent of which is estradiol. The
other important—but less powerful—estrogens are estrone and
estriol. Estrogens affect the growth, differentiation, and function
of diverse target tissues—not only those involved in the reproductive
process, but tissues throughout the body. Estrogens play
an important role in bone formation and maintenance, exert cardioprotective
effects, and influence behavior and mood.
Although estrogen is best known for its critical role in female
reproduction, less well known are the important actions of estrogen
in male tissues, such as the prostate and testes.1,2
In women, estrogens are synthesized from cholesterol in the
ovaries in response to pituitary hormones. In an adult woman
with normal cycles, the ovarian follicle secretes 70 to 500 μg of
estradiol per day, depending on the phase of the menstrual cycle.
Estradiol can be converted to estrone and vice versa, and both
can be converted to the major urinary metabolite, estriol.
Estrogens are also produced by the aromatization of androgens in
fat cells, skin, bone, and other tissues. After menopause, most
endogenous estrogen is produced in the peripheral tissues by the
conversion of androstenedione, which is secreted by the adrenal
cortex, to estrone. In addition, some estrogen continues to be
manufactured by aromatase in body fat, and the ovaries continue
to produce small amounts of the male hormone testosterone,
which is converted to estradiol. The total estrogen produced after
menopause, however, is far less than that produced during a
woman’s reproductive years.1,2A brief description by DOUGLAS C. HALL, M.D.
relative to PC, the levels of androgens at the start of replacement probably plays a big role.
This link is great and newer.
http://www.lef.org/magazine/mag2008/nov2008_Dangers-of-Excess-Estrogen-in-the-Aging-Male_01.htm
I had prostate problems for yrs even had sugary I call it a Rem Job. I found out my Estradiol levels on TRT were very high 6 yrs ago and getting this down with Arimidex fixed a lot of problems I had ED, slow voiding and many others to many to list. After keeping my Estradiol level down to about 20 pg/ml my prostate came down in size to normal for my age.
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