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im assuming optimizing thyroid, adrenal, ferritin, iodine, TT/e2
is enough to optimize neurtotranmitters and optimize PE, hopefully..
@BlackJack 525 wrote:
Dr. M could u use l-glutamine to increase GABA to help reduce norephinen?
No. But that’s an interesting thought.
@The450Man 530 wrote:
what about pikamilon? Gaba binded with niacin; it can cross the BBB.
Pikamilon is an interesting substance. It is GABA bonded to Niacin via a covalent bond that is suppose to be hydrolyzed, releasing GABA and Niacin. The GABA and Niacin can then do their own actions.
It is suppose to last as a bonded product about 2.5 hours. GABA and Niacin have their own duration of action.
It is a whole new molecule. It is not a supplement that occurs naturally in nature. It is an artificial substance. It is a prescription product in Russia. But is available over-the-counter in the US because no one sees yet that it is actually a new substance and thus is a drug.
I have no experience with this substance. Since it is hydrolyzed into GABA and Niacin, one can look at the pros and cons of each. However, the pros and cons of the mother substance, Pikamilon are not known. Will it do something unexpected or dangerous? I don’t know.
Niacin also reduces cholesterol. This can be a problem in the brain since excessive cholesterol reduction reduces brain function. Realize that half of the dry weight of the brain is cholesterol! One problem would be memory and concentration problems.
It is an interesting substance. It may be useful or not. I don’t know yet.
The only problem is for me when i start taking stuff like gaba, 5htp, etc, i notice it does help with PE but it also lowers libido..
PE is such a tough thing to solve at least for me.
@BlackJack 588 wrote:
The only problem is for me when i start taking stuff like gaba, 5htp, etc, i notice it does help with PE but it also lowers libido..
PE is such a tough thing to solve at least for me.
The question I would have is what causes norepinephrine to be high in the first place?
For example, norepinephrine signaling may be elevated to compensate for some problem in generating energy. This may be, for example, due to hypothyroidism, impaired cortisol production, the lack of adequate nutrients involved in energy production such as the B-vitamins, Vitamin A, iron, zinc, selenium, etc.
The body’s own natural suppressants of norepinephrine signaling may be off, such as a deficiency of testosterone, cortisol, etc.
Addressing the cause or these causes of excessive norepinephrine signaling may have a better outcome than suppressing norepinephrine directly, which can cause decreased libido despite helping reduce premature ejaculation.
i have figured out from the beginning..
i was low in Testosterone, DHEA, Cortisol; Hypothyroidism, Ferritin, Vit D, Magnesium, Zinc, Iodine..
the problem is i fixed 80% of these things and still have problems.
i fixed my low test, dhea, im on 2.5 grains,, i bought ferritin from 20 to 80;; 20mg Cortef
and im no longer deficient in vit, magnesium, zinc..
i did just find out i was low in iodine and started working on that
interesting i was able to last about 5-10mins when i was on Clomiphene.
overall i found PE is strongly linked to having ED…
beacuse when im able to get that once in awhile good erection i dont seem to have PE or not as bad… and when i take a cialis im able togo longer.
@BlackJack 616 wrote:
interesting i was able to last about 5-10mins when i was on Clomiphene.
With testosterone, an important consideration is the testosterone to estrogen ratio. Estradiol, being the strongest estrogen, can be used for determining this ratio.
Estrogen is necessary for sexual drive or libido. However, too little or too much can impair libido. Too much estrogen can increase stress/norepinephrine signaling, cause irritability, anxiety, agitation, etc. This can worsen or contribute to premature ejaculation.
Clomiphene (Clomide) and Tamoxifen (Nolvadex) are both weak estrogens that bind to the estrogen receptor and block the stronger estrogens like Estradiol. This reduces the strength of estrogen signaling. And if a man is not too old, this may also cause an increase in LH, which then leads to an increase in testicular testosterone production. These changes increase the testosterone to estrogen signaling ratio. This may, in some men, improve libido and reduce premature ejaculation. In many other men, however, who already have a good testosterone to estrogen ratio, a weakening of estrogen signaling will reduce libido instead of improving it.
@BlackJack 699 wrote:
Dr. M
would HCG (chorionic gonadotropin) have similiar effects?
HCG, acting like LH increases testicular progesterone production, which leads to an increase in testosterone production. It also increase aromatase enzyme production, which leads to an increase in estradiol production from testosterone.
Thus HCG has different effects from Clomid or Tamoxifen since it does not block estrogen signaling like Clomid or Tamoxifen. HCG leads to an increase in testosterone but also an increase in estradiol. The increase in estradiol may be excessive in some men, not all. Whether or not it reduces premature ejaculation varies depending on the resulting testosterone to estradiol ratio. It is difficult to predict unless a person gives it a try. Generally, daily dosing produces the best effect in the treatment of hypogonadism.
Epinephrine (µg/gCr) 8.0 (8 – 12)
Norepinephrine (µg/gCr) 53.5 (35-50)
Dopamine (µg/gCr) 188.5 (110 – 175)
Serotonin (µg/gCr) 109.2 (150 – 200)
Glycine (umol/gCr) 75.5 (200 – 400 )
Taurine (umol/gCr) 154.4 (150 – 550)
GABA (umol/gCr) 1.2 (1.5 – 4 .0)
Glutamine (umol/gCr) 217.6 (150 – 500)
Glutamate (umol/gCr) 16.2 (10 – 35)
Aspartic Acid (µmol/gCr) 22.6 (20 – 40)
PEA (nmol/gCr) 213.3 (175 – 450)
Agmatine (ug/gCr) 3.6 (1-2)
Histamine (ug/gCr) 20.4 (10-20)
Creatinine (mg/dL) 262.5 ( N/A )
EXCITATORY:
Epinephrine (µg/gCr) 8.0 (8 – 12)
Norepinephrine (µg/gCr) 53.5 (35-50)
Dopamine (µg/gCr) 188.5 (110 – 175)
Histamine (ug/gCr) 20.4 (10-20)
Glutamate (umol/gCr) 16.2 (10 – 35)INHIBITORY:
Serotonin (µg/gCr) 109.2 (150 – 200)
GABA (umol/gCr) 1.2 (1.5 – 4 .0)
Glycine (umol/gCr) 75.5 (200 – 400 )Glutamine (umol/gCr) 217.6 (150 – 500)
Taurine (umol/gCr) 154.4 (150 – 550)
Aspartic Acid (µmol/gCr) 22.6 (20 – 40)
PEA (nmol/gCr) 213.3 (175 – 450)
Agmatine (ug/gCr) 3.6 (1-2)—-
What one could say about the above:
Norepinephrine is high. Dopamine is primarily leakage from norepinephrine neurons, as a precursor for norepinephrine. Since dopamine is high, this also supports the notion that Norepinephrine is high. Thus stress signaling is high.
Histamine is high. Histamine is a signal for stress. It is a stimulant neurotransmitter. It can be high when norepinephrine is high, as part of the stress response.
Serotonin is low. Serotonin is one of the control signals for Norepinephrine.
GABA is low. GABA is one of the control signals for Norepinephrine. It is the primary inhibitory neurotransmitter in the nervous system.
Glycine is low. Glycine is also one of the inhibitory neurotransmitters in the nervous system.
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Thus, on whole, stimulant/stress signals are up. Calming signals are down.
High norepinephrine predisposes a person to premature ejaculation.
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