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Amphetamine Treatment Similar to That Used in the Treatment
of Adult Attention-Deficit/Hyperactivity Disorder Damages
Dopaminergic Nerve Endings in the Striatum of Adult
Nonhuman Primates@compaq 4886 wrote:
What to take from this?
Amphetamines might be bad for our brains?
. Amphetamine massively down regulates VMAT2 which has all sorts of effects from Parkinson’s disease to depression, both which have been shown to occur at alarming rates in amphetamine users. Ritalin doesn’t down regulate VMAT2 but up regulate it
The low dose of amphetamine is less likely to have side effect on the brain, but anybody known after long period of low dose of amphetamine is a really bad or not.
With that said, lithium has been shown to up-regulate VMAT2 as well as D2/D3 autoreceptors (which are important in combating dopamine dysregulation). There is also reason to believe that increased VMAT2 could help prevent amphetamine induced neurotoxicity, though much of the research I’m quoting used rat studies.
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