My labs (previous endo said i was fine — theres no way)

[nickatnite]

So here are my labs. So far it has been determined that I have insulin resistance. My primary and his referred Endocrine told me I was fine and within reference ranges. I do not look fine and I definitely do not feel fine. I would love to hear other comments on some other possibilities. Thanks so much. Diet is pretty solid and I work out 3x a week.. I’ve also attached pics. Right now I’m taking 50mg TD DHEA cream — and have been for 2 months. I’m wondering if Dr. M has ever seen labs like this?

Here are my labs before the cream:

Latest labs of June 2010

Enjoy, for those that want to read:

CORTISOL 13.1 [4.3 – 22.4] UG/DL
LH 4.8 [1.5 – 9.3] MIU/ML
T4 7.0 [4.7 – 11.4] MCG/DL
T7(T4 X TU) 2.3 [1.6 – 3.4]
TSH(SENSITIVE) 0.548 [0.350-5.500] UIU/ML
THYROID UPTAKE 32.8 [24.0 – 38.9] %

TESTOSTERONE 298 [262-1593] NG/DL
SHBG 7 [13-71] NMOL/L
CFAA 147.6 [14.8-94.8]
INSULIN 17.2 [<27] UIU/ML

VIT. D, 25 HYDROXY 43.2 [30.0-100.0] NG/ML

REVERSE T3 190 [90-350] PG/ML

COPPER 90 [70-175] MCG/DL

EPINEPHRINE <10 [<84] PG/ML
NOREPINEPHRINE 206 [<420] PG/ML
DOPAMINE <60 [<30] PG/ML

TOTAL CATECHOLAMINES
(Unable to accurately calculate since one or more components
is below detection limit)

ESTRADIOL, Ultra Sensitive 20 < OR = 29pg/ML INSULIN, Free (Bioactive) 15.1 [1.5-14.9] uIU/mL TESTOSTERONE (Bioavaililable) 241 ng/DL 62-512
TESTOSTERONE (Total) 309 ng/DL 241-827

CORTISOL, FREE 0.29 mcg/dL

DHEAS (Blood) 312 [280-640] MCG/DL

DHEA (24hour Urinalysis)

Total Volume: 2300 mL

DHEA, Urine: 236 mcg/24h 21-2710

DHEA, Urine: 88 mcg/g creat 24-1640

CREATININE, 24-hour 2.68 0.63-2.50

[nickatnite]

[nickatnite]

Just a quick note — The new DR that I have been seeing is definitely making a huge difference and seems to know what he’s talking about — however I want to make sure there’s not something else we could be missing besides the insulin resistance — like pituitary failure, some kind of tumor causing all of this

[DrMariano2]

I’ve seen all kinds of labs.

Being “within normal limits” is not good enough. That implies not considering the actual physiologic meaning of a lab finding. The actual question should be what is the “optimal” level for any individual that results in wellness.

Insulin resistance or prediabetes or diabetes type 2 has multiple contributing factors or causes.

Some include:
1. suboptimal thyroid hormone. If thyroid hormone is optimized, as Broda Barnes MD found, diabetes can be prevented.
2. excessive norepinephrine/stress signaling.
3. hypogonadism. The total testosterone range I prefer is 300-1000 ng/dL.
4. suboptimal vitamin D.
5. obesity – which can lead to increased inflammatory cytokine signaling, norepinephrine signaling, estrogen signaling, and suboptimal thyroid signaling, among other problems.
6. adrenal dysregulation may contribute to an increase in norepinephrine signaling, inflammatory signaling, with multiple downstream problems including insulin resistance.

High insulin signaling is a sign of insulin resistance. I generally like to see total insulin < 10.
Insulin is also a signal to store fat – leading to a positive feedback signaling loop(s) that worsens insulin resistance.
Insulin, itself, is a pro-inflammatory signal.

Low SHBG may be contributed to by excessive insulin signaling.

When one does not feel well, it is important to continue looking for what is causing this problem. When someone says “It is all in your mind.” My answer to that is that the mind is the body. And one has to keep looking for what is being missed.

[Author]

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