- This topic is empty.
-
Posts
-
In the April 2010 Life Extension magazine, William Faloon states that he takes 850mg of Metformin 2-3x/day to “reduce my risk of a host of age-related diseases”. Does anyone have any opinion on the pros and cons of following this regimen?
Latest topic for anti aging.Metformin is a drug old, who is currently applied in the aging world. The reason behind the object and its relevance to the degeneration of cells depends on how he will react to your skin.
My brother used to take Metformin for few years and he had good results. But due to some liver problem he changed to Glypizide and then after he never had the same results that he achieved while he was on Metformin.
@adamtaylor 2820 wrote:
My brother used to take Metformin for few years and he had good results. But due to some liver problem he changed to Glypizide and then after he never had the same results that he achieved while he was on Metformin.
When you say he had “good results” do you simply mean his blood sugar was kept under control or do you mean there were general anti-aging/positive results as measured by blood tests or other clear signs that Metformin was doing more good than just controlling blood sugar?
@Gardiner 2626 wrote:
In the April 2010 Life Extension magazine, William Faloon states that he takes 850mg of Metformin 2-3x/day to “reduce my risk of a host of age-related diseases”. Does anyone have any opinion on the pros and cons of following this regimen?
Metformin reduces blood sugar production from the liver by raising insulin sensitivity in the liver. This helps lower blood sugar, which then reduces insulin signaling. Metformin also reduces intestinal sugar absorption.
Insulin signaling increase fat storage, increasing the risk for obesity.
Insulin is also a pro-inflammatory signal.
Metformin reduces insulin resistance in the liver, but does not reduce insulin resistance in the rest of the body. This causes a mismatch between the brain and body’s requirement for blood sugar and the liver’s production of blood sugar. This can cause fatigue and impairment in brain function.
Since it does not address insulin resistance in the brain and body, and since it can deprive the brain of adequate sugar production, Metformin – particularly in the absence of additional treatments that address brain and body insulin resistance – increases the risk for dementia or Alzheimer’s disease.
Metformin can be useful as part of an overall treatment. However, it has significant risks when used alone. Thus, as an anti-aging treatment, one has to be careful, otherwise, it may instead lead to the same problems one is trying to avoid.
- You must be logged in to reply to this topic.