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@BlackJack 202 wrote:
Are adrenal hormones or thyroid hormones related to histamina?
how would you lower histamine?
From my point of view, the whole body is a fluid circuit – which is very similar to an electrical circuit – but enormously more complex by several magnitudes.
HISTAMINE:
Histamine is one of the stress response signals as is norepinephrine. Both histamine and norepinephrine are produced in response to stress. Both are stimulant signals which keep the mind alert.
Histamine directly activates the immune system and contributes to the inflammatory response. Histamine increases IL-6, a pro-inflammatory cytokine signal from brain astrocytes. This stimulates immune system activity.
Histamine can increase norepinephrine in the brain and indirectly through the renin-angiotensin-aldosterone system. Histamine and norepinephrine both stimulate renin production. This through intermediate steps leads to an increase in angiotensin II, which then increases norepinephrine signaling from the sympathetic nervous system and increases aldosterone signaling.
Histamine may cause an increase in blood flow via H2 receptors and a decrease in blood flow via H1 receptors.
Histamine can stimulate nervous system myelination – important to improve signal processing. It can also help increase Vitamin B12 absorption in the process of improving myelination.
HISTAMINE AND ADRENAL HORMONES:
By increasing norepinephrine signaling, histamine affects adrenal function. It increases adrenal output as part of the stress response.
Note, however, as exhaustion of the stress response occurs, and hypothalamic-pituiatr
HISTAMINE AND THYROID:
The relationship between histamine and thyroid hormone is very very complex.
Histamine causes the release of thyroid releasing hormone, leading to an increase in thyroid stimulating hormone, leading to an increase in thyroid hormone.
Thyroid hormone may lower histamine by decreasing brain histamine release and reduce the number of brain mast cells which release histamine.
Thyroid hormone may increase the body’s histamine by blocking histamine degradation.
Thyroid hormone may increase sensitivity to histamine, but this is blocked by cortisol.
The immune system has interactions with histamine and thyroid. For example, thyroid microsomal antibodies are increased, often histamine-releasing antibodies are also present.
LOWERING HISTAMINE:
One can lower stress to reduce the stress response.
Antihistamines are very commonly used medications to reduce histamine.
What about if someone had low histamine? Would that lead to an increase in norepinephrine? If so, would there potentially be some benefit to raising histamine levels in someone who had low histamine levels and high norepinephrine?
@smitty4 282 wrote:
What about if someone had low histamine? Would that lead to an increase in norepinephrine? If so, would there potentially be some benefit to raising histamine levels in someone who had low histamine levels and high norepinephrine?
Low histamine does not necessarily correlate with high norepinephrine.
In patients with high norepinephrine levels, histamine doesn’t necessary rise also, though in many it may. Norepinephrine is a more consistent measure of stress than histamine.
Increasing histamine would raise norepinephrine. I’m not sure this is what one wants to do if norepinephrine is already high.
@DrMariano 287 wrote:
Low histamine does not necessarily correlate with high norepinephrine.
In patients with high norepinephrine levels, histamine doesn’t necessary rise also, though in many it may. Norepinephrine is a more consistent measure of stress than histamine.
Increasing histamine would raise norepinephrine. I’m not sure this is what one wants to do if norepinephrine is already high.
I see…that makes sense.
I guess I am trying to figure out how someone who has low dopamine (and family history of Parkinsons) and high norepinephrine (based on urine labs) would raise the dopamine and lower the norepinephrine. Since norepinephrine is synthesized from dopamine, it seems that increasing dopamine would also increase norepinephrine.
@smitty4 289 wrote:
I see…that makes sense.
I guess I am trying to figure out how someone who has low dopamine (and family history of Parkinsons) and high norepinephrine (based on urine labs) would raise the dopamine and lower the norepinephrine. Since norepinephrine is synthesized from dopamine, it seems that increasing dopamine would also increase norepinephrine.
Increasing dopamine does not necessarily increase norepinephrine.
Dopamine-releasing neurons do not go the extra step necessary to transform dopamine to norepinephrine. That would defeat the purpose of releasing dopamine since norepinephrine and dopamine often trigger the opposite things. For example, dopamine can be sedating, norepinephrine promotes wakefulness. Dopamine can lower blood pressure, norepinephrine increases it.
Increasing norepinephrine may lead to leakage of dopamine from norepinephrine cells since dopamine is the precursor for norepinephrine. However, this amount is small compared to the amount of norepinephrine released. This dopamine is not localized to the same area as dopamine from dopamine neurons. It is rapidly destroyed before it can get out of the synapse and influence targets of dopamine neurons. This is why increasing norepinephrine is not a good way to treat Parkinson’s disease. It may overall reduce dopamine production instead.
@DrMariano 290 wrote:
Increasing dopamine does not necessarily increase norepinephrine.
Dopamine-releasing neurons do not go the extra step necessary to transform dopamine to norepinephrine. That would defeat the purpose of releasing dopamine since norepinephrine and dopamine often trigger the opposite things. For example, dopamine can be sedating, norepinephrine promotes wakefulness. Dopamine can lower blood pressure, norepinephrine increases it.
Increasing norepinephrine may lead to leakage of dopamine from norepinephrine cells since dopamine is the precursor for norepinephrine. However, this amount is small compared to the amount of norepinephrine released. This dopamine is not localized to the same area as dopamine from dopamine neurons. It is rapidly destroyed before it can get out of the synapse and influence targets of dopamine neurons. This is why increasing norepinephrine is not a good way to treat Parkinson’s disease. It may overall reduce dopamine production instead.
Thank you!
I was curious as to whether taking Amantadine in an effort to increase ones dopamine levels could automatically cause an increase ones norepinephrine. Sounds like that is not the case. That’s what I get for making assumptions. đŸ™‚
As with everything else in life…the more I learn, the more I realize that I do not know!
It has been my experience that there aren’t a lot of doctors prescribing Selegiline. I always thought it was due to the fact that you then have to avoid tyramine, which would seem to me to reduce a patient’s willingness to stay on it long-term. I can see someone staying on it if they had Parkinson’s, but I can see how their might be compliance issues if it was just to raise dopamine levels a little bit. If one accidently ate the wrong thing, they may stop taking the med.
I would think there would be better alternatives…like a low dose of Dextroamphetamine. I don’t see or hear of a heck of a lot of PCPs prescribing that either.
I just realize that this conversation is probably high jacking this thread off topic and I apologize.
Hello I am new to this forum. I have a question for Dr M. I have high histiDine blood levels per a Metamatrix Cardio Ion Panel. I just received test results from a Neuroscience Neurotransmitter urine test and the histaMine level is elevated as well as all my neurotransmitters. I had been on cortisol foe a year and weaned off and my cortisol morning saliva is medium range, afternoon is high, evening is high and night is normal. I take 1 grain of Naturethyroid and 2 pumps daily of estrogel with 0.1ml estriol. Ten years ago I became allergic to all nuts and nut oils. Last year I had an allergic reaction to pineapple and now have to carry an Epi-pen.
I am in almost constant anxiety. I have been having ocular migraines, crying when I can’t handle stress, depression, feel like I am barley holding it together. My doctor wants me to take either Lexapro or Zoloft. I was on zoloft last yeAr and it did nothing for me. This has been going on for almost two years. Cortisol dud nothing for the anxiety
My question is when you say “antihistamine” are you referring to Benadryl type products? I have read that using 500mg 2xs daily of methione (sp?- amino acid) helps reduce the histamine. I was also told Quercitin reduces histamines. I do not have seasonal allergies. I just need some direction. Thank you
Histamine can improve norepinephrine in the mind and in a roundabout way through the renin-angiotensin-aldosterone program. Histamine and norepinephrine both activate renin generation. This through advanced steps causes a rise in angiotensin II, which then improves norepinephrine signaling from the supportive neurological program and improves aldosterone signaling.
Histamine can improve norepinephrine in the mind and in a roundabout way through the renin-angiotensin-aldosterone program. Histamine and norepinephrine both activate renin generation. This through advanced steps causes a rise in angiotensin II, which then improves norepinephrine signaling from the supportive neurological program and improves aldosterone signaling.
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