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Im trying to understand the effect of using a beta blocker such as Inderal for anxiety while someone is also suffering from untreated adrenal fatigue.
The other question is how would the use of Hydrocorisone or Isocort be effected by the use of Inderal? Thanks!
@ssavanna 1216 wrote:
Im trying to understand the effect of using a beta blocker such as Inderal for anxiety while someone is also suffering from untreated adrenal fatigue.
The other question is how would the use of Hydrocorisone or Isocort be effected by the use of Inderal? Thanks!
Propranolol (Inderal) is a medication which blocks Norepinephrine/Epinephrine (adrenergic) receptors – primarily the beta-type receptors.
By blocking beta adrenergic receptors in the brain, it can help reduce anxiety or stress. It is often used for situational stress or performance anxiety – such as during public speaking, playing a musical instrument in front of a crowed, test anxiety, etc.
By blocking beta adrenergic receptors, it also helps reduce renin production, which helps also reduce the activity of the stress system.
This reduction in stress signaling may improve regulation of hypothalamic-pituitary-adrenal axis function, helping restore function.
The treatment with beta-blockers, however is a double-edged sword.
The problem of long-term use of beta-blockers, is that they may also suppress the conversion of T4 (inactive thyroid hormone) to T3 (active thyroid hormone). Patients may then become hypothyroid, which may increase stress-system activity in compensation, which then may activate pro-inflammatory cytokine signaling, which would then result in HPA Axis dysregulation with low cortisol production
This may or may not occur in patients depending on a variety of factors. But it should be considered in follow up assessments.
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The effect on treatment with hydrocortisone (including IsoCort treatment) generally does not need to be changed since a subphysiologic dose is what is desired from treatment with hydrocortisone, not a supraphysiologic level when doing supportive treatment for adrenal function.
For OP, I can also tell you that I used metoprolol when I had high BP years back (since TRT, I’ve lost about 40 pounds and have no need for meds!) and the drug made it virtually impossible to acheive an erection suitable for penetrative sex.
I would liken it to trying to have sex after about the tenth shot (not that I advocate that).
I understand this is a pretty common side effect for this class of medication, so make sure to consider that with your doc.
Also, I have been on Isocort for adrenal support for about a month and some change now, and it has made a difference for me. It wasn’t an abrupt change (like I had hoped), but I just generally started feeling better after about 3 weeks. I also found my response to caffeine was back, which is what alerted me that something changed.
So it’s definitely something to talk to your doc about.
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