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If one was going to get for cytokine imbalances in the serum what blood profile would be ran.
Patient has FM and extreme pain has been several diffferent dr’s with no resolution just more medicine. They never examined her cortisol levels which when I explained her if cortisol level are low that this could have a major effect on pain. We are running a cortisol salvia with a comprehensive blood work on thyroid, sex hormones. I was looking markers other then c reactive proteins. I want to focus on immoglobulins, t cells, b cells, ect, but I do not know what is a complete profile to examine these markers.@hardasnails1973 104 wrote:
If one was going to get for cytokine imbalances in the serum what blood profile would be ran.
Patient has FM and extreme pain has been several diffferent dr’s with no resolution just more medicine. They never examined her cortisol levels which when I explained her if cortisol level are low that this could have a major effect on pain. We are running a cortisol salvia with a comprehensive blood work on thyroid, sex hormones. I was looking markers other then c reactive proteins. I want to focus on immoglobulins, t cells, b cells, ect, but I do not know what is a complete profile to examine these markers.Unfortunately, the state of the art is just not there yet. Measuring cytokines is also very expensive and is generally not done.
There aren’t criteria yet for what is “high” or “low” when it comes to cytokines and the correlation between those levels and health changes. I haven’t’ determined it yet, myself.
Unfortunately, also, each person’s level may be different such that only a comparison to oneself at different time points would make a difference.
Specific antibodies can be found for specific illnesses – such as thyroid stimulating antibody in Graves Disease, and thyroid peroxidase antibodies in Hashimoto’s thyroiditis.
Currently, the immune system messages are either pro-inflammatory or anti-inflammatory (primarily IL-10). Given this fairly crude level of message interpretation, assessing immune system function is generally easier by taking a history and physical, than by lab testing. A history of multiple inflammatory conditions or diseases is evidence for a preponderantly pro-inflammatory state.
Even C-reactive protein and erythrocyte sedimentation rate can be low yet a person has a lot of inflammatory processes occurring. Thus they aren’t reliable as measurements of general inflammation, though they may be useful in specific illnesses such as heart disease and temporal arteritis. But if they are high, one has additional data about the presence of a proinflammatory state.
Hormones can be classified also as pro-inflammatory and anti-inflammatory. Histamine and estrogen can be considered inflammatory. Thyroid, testosterone, DHEA, progesterone, cortisol can be considered, anti-inflammatory.
Similarly, neurotransmitters can be classified as pro-inflammatory and anti-inflammatory. Norepinephrine and histamine are proinflammatory. Dopamine, serotonin, and GABA are anti-inflammatory.
Using information from the history, physical exam, and information about the other systems – which are much easier to measure than the immune system at this point in time – one can then determine whether or not a person is in a pro-inflammatory versus anti-inflammatory state. This would then be useful in determining the course of action in treating a person – for example, whether or not to use something that would block proinflammatory cytokines, etc.
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