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  • #1233
    The450Man
    Member

    Finally got Free t3 free t4 and antibodys checked……..

    I have anxiety, fatique, depression, overactive gag reflex……

    Free t3: 4.4 2.1-4.2pg/ml

    Free t4 1.6 .8-1.8 ng/dl

    Thyroglobulin Autoantibodies 33 <60

    Thyroid Peroxidase Autoantibodies 15 <60

    Past blood tests:

    6/4/09

    Testosterone, Total 670 250-1100 ng/dL
    Testosterone, Free 101.1 46.0-224.0 pg/mL
    Testosterone, Bioavailable 221.0 110.0-575.0 ng/dL
    SEX HORMONE BINDING GLOBULIN 30 7-49 nmol/L
    ALBUMIN 4.8 3.6-5.1 g/dL
    ESTRONE, SERUM 144 < OR = 68- PG/ML
    5/18/09

    Estradiol, Free 0.47 < OR = 0.45- PG/ML
    Estradiol, % Free 2.33 1.25-1.85 %
    Estradiol 20 < OR = 29- PG/ML
    T3 Reverse 25 11-32 ng/dL
    Free T4 1.3 0.8-1.8 NG/DL
    TSH (Third Generation) 2.36 0.40-4.50 mU/L
    Progesterone 1.1 <1.4- NG/ML
    Prolactin 11.9 2.0-18.0 NG/ML
    Testosterone 602 241-827 NG/DL
    Cortisol 17.7 3.0-17.0 MCG/DL
    Follicle Stim.Hormone(FSH) 3.9 1.6-8.0 MIU/ML
    Luteinizing Hormone(LH) 8.9 1.5-9.3 MIU/ML
    Pregnenolone 133 13-208 NG/DL

    2/10/2009
    ESTROGENS, TOTAL 99 130 OR LESS (ADULT)- PG/ML

    12/23/08
    TSH (Third Generation) 1.34 0.50-4.30 mU/L
    ESTROGENS, TOTAL 198 130 OR LESS (ADULT)- PG/ML
    Testosterone 657 241-827 NG/DL

    7/26/07
    TSH (Third Generation) 0.80 0.70-6.40 mU/L

    #3062
    The450Man
    Member

    I also just got my DHEA levels in……… quite low

    DHEA, Uring 58 mcg/24hour 21-2710
    DHEA, Uring 25 mcg/g creat 24-1640
    Creatinine, 24 hour urine 2.37 g/24hour .63-2.50

    Should i start supplementing with DHEA?

    #3058
    DrMariano2
    Participant

    TOTAL T4: I believe a crucial and not often obtained level is Total T4. This gives one an idea of the total output of the thyroid gland. It also helps determine dosing during replacement therapy.

    FREE T3: The adult upper limit is 4.2. Generally, I do not dose over this limit. There are rare occasions when I dose over 4.2 in an adult. The children’s upper limit is 5.2. This is lost in the transition to adolescence. Generally, if Free T3 < 3.3, that person would be hypothyroid (or have suboptimal thyroid) from a mental health perspective. I would also tend to see physical signs of hypothyroidism.

    FREE T4: Generally, if Free T4 < 1.2, then a person may be hypothyroid (or suboptimal thyroid) from a mental health perspective.

    THYROID PEROXIDASE ANTIBODIES, THYROGLOBULIN ANTIBODIES: help screen for Hashimoto’s Thyroiditis, a usually more severe form of hypothyroidism where the immune system attacks the thyroid gland, considering it foreign to the body.

    TOTAL TESTOSTERONE: A Total Testosterone of 650 ng/dL is excellent for a 20 year-old. This is the level I target in testosterone replacement therapy. There can be day-to-day variability in testosterone production depending on numerous factors including nutrition.

    TSH: can often be unreliable as a measure of thyroid hormone – particularly when the brain is not working well – as in depression. It would be better to obtain a Total T4, Total T3, Free T4, Free T3 to determine thyroid signaling activity.

    DHEA: DHEA-s is a good test for DHEA. To interpret urine DHEA levels, one needs to also know what the metabolite levels of DHEA are. If there are a lot of metabolites, for example, yet low DHEA, one could state the there is enough DHEA and that much of it is being actively used – and thus converted to its metabolites. A low urine DHEA level does not tell much. It does not say whether or not actual serum DHEA levels are high or low since the information about its metabolites is missing.

    CORTISOL: A morning fasting non-stressed resting Cortisol between 17 to 22 is generally good. If the other adrenal cortex signals (e.g. DHEA-s, Pregnenolone, Progesterone) were present, then early stage HPA Axis dysregulation with low cortisol output would be easier to see. In this state, Cortisol is maintained, but production of the other signals is reduced. If stress levels were high – e.g. if Plasma Fractionated Catecholamines showed a norepinephrine level of 600+, then a Cortisol of 17 may be considered low for the associated stress level.

    #3063
    The450Man
    Member

    man i wish i could come out to cali and give you a visit.

    I really cant afford much more of anything else as far as test wise goes…… insurance only goes so far.

    With the information provided, what would be a good direction to go in as to improve my being? Supplements? The low levels of dhea kinda startled me…….. adrenal fatigue? ive always assumed ive had some kind of disregulation… high t3 a sign of hyperthyroidism? could explain my anxiety..

    Im currently taking:

    Morning (i wake up at like 11-1)

    1200mg fish oil
    B complex
    Trytophan 500mg (just started)
    zinc 50mg
    Cal-Mag-Zinc sup
    Ashwagondha 200mg

    Afternoon (my afternoon is like 5)

    Tryptophan 500mg
    B complex

    Before bed

    1800 mg fish oil
    B complex
    Tryptophan
    Multi vitamin
    Cal-mag-zinc
    creatine 4 grams.

    would supplementing with dhea hurt? Aromitization an issue? i already have “high” estrogen………

    #3059
    DrMariano2
    Participant

    ESTROGEN: Generally I like to see a testosterone ratio (in ng/dL) to estradiol (in pg/mL) of about 20:1 to 30:1. For example, a testosterone of 650 ng/dL and an estradiol of 20 is greater than 30:1. Thus estrogen could be considered low in this male. Some practitioners like to see a fixed optimal Estradiol around 20-24 pg/dL. Thus an estradiol of 20 is just about right.

    DHEA: a single urine DHEA level does not tell much. It doesn’t even tell if the actual serum levels are high or low. A serum DHEA-s is a preferable test to a urine DHEA without its metabolites.

    TOTAL ESTROGENS: does not tell much. For example, most of those are Estriol or other weak estrogens, then the actual estrogen signaling strength is low despite having a large number of estrogens. An ultrasensitve estradiol is a better measure of estrogen signaling strength.

    FREE T3: in a young person, a mildly elevated Free T3 may not mean much, particularly if the other thyroid tests are not elevated and adrenal function is intact.

    ANXIETY: excessive norepinephrine signaling leads to anxiety as the predominant mood. Generally, when adrenal function is reduced, norepinephrine signaling may rise since cortisol helps stop the norepinephrine-to-CRH positive feedback loop.

    B-COMPLEX: Excessive Vitamin B6 may cause nervous system toxicity, e.g. when nearing 500 mg a day of B6., with symptoms including numbness, pain, tingling in the extremities and difficulty walking.

    #3061
    pmgamer18
    Member

    Doing Zinc lowers Copper so try taking 2mgs of copper at a different time then you take the zinc. We men need Zinc so just add a little copper.
    @The450Man 1255 wrote:

    man i wish i could come out to cali and give you a visit.

    I really cant afford much more of anything else as far as test wise goes…… insurance only goes so far.

    With the information provided, what would be a good direction to go in as to improve my being? Supplements? The low levels of dhea kinda startled me…….. adrenal fatigue? ive always assumed ive had some kind of disregulation… high t3 a sign of hyperthyroidism? could explain my anxiety..

    Im currently taking:

    Morning (i wake up at like 11-1)

    1200mg fish oil
    B complex
    Trytophan 500mg (just started)
    zinc 50mg
    Cal-Mag-Zinc sup
    Ashwagondha 200mg

    Afternoon (my afternoon is like 5)

    Tryptophan 500mg
    B complex

    Before bed

    1800 mg fish oil
    B complex
    Tryptophan
    Multi vitamin
    Cal-mag-zinc
    creatine 4 grams.

    would supplementing with dhea hurt? Aromitization an issue? i already have “high” estrogen………

    #3060

    @pmgamer18 1264 wrote:

    Doing Zinc lowers Copper so try taking 2mgs of copper at a different time then you take the zinc. We men need Zinc so just add a little copper.

    Yes very good point as we proved to a Dr that this can occur when both of them are taken together instead of separate can cause a deficiency. Proper balancing of minerals is an art form that alot of people end up causing a metabolic mess because they start shot gunning supplements not knowing their interactions. After dealing with this for over 4 years my self it took me alot of time to learn how to undo them. As your high t3 it is most likely from pulling too much due to low cortisol.

    Dr M
    When you see people with armour that have a good t4 total low ft4 .1 and higher ft3 conversion, would you recommend that person try to increase their t-4 with synthroid?
    I am seeing a lot of people that fall into this category and it these people that end up chasing their tails for a long time despite proper cortisol levels. I also see people that take armour and have equal ft4 and ft3 numbers. For people that are over converters who had low adrenals could this be a sign of their adrenals are regulated?

    #3064
    Mebigusmall
    Member

    What mental issues can a slightly high TSH cause, above 2.0?

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