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Just to let everyone here know i have been having problems with chronic fatigue for the past 6-8 months and symptoms such as dizziness, muscle weakness, brain fog, weight loss, numbness and tingling and reduction in the sense of touch etc. they are many more but too many to list. And with the ONE test from genova i was able to get a recommendation from hardasnails on a supplement schedule tailored to my needs.
Im on 4mg of Folinic Acid
10mg Methylcobalamin
100mg P5Pper day.
Its only been one week but im feeling tremendously more energy, alot better mental capacity and thinking, sensations are slightly better and muscle weakness isn’t as bad. Much less swelling/fluid retention also.
I had highly elevated Sarcosine which is a indicator of severe function folate deficiency.
Very elevated glutamates due to the biological stress im experiencing whatever the reason it maybe (nutrient deficiencies, infection or hormonal hypofunctions
Elevated Beta-aminoisobutryic acid probably due to excellerated catabolism of DNA/RNA due to folic acid deficiency as well as these levels being elevated themselves due to B12 Deficiency.
One thing that intrigues me about this test is it says:
Elevated glutamic and aspartic acid has been described in the literature as:
Dicarboxylic Hyperaminoaciduria. This is a rare disorder of autosomnal recessive inheritance and features renal wasting due to (renal tubule transporter defect) of dicarboxylic structured amino acids. Unpublished clinic observations of several cases link the condition to toxic chemical exposures or to the use of narcotics or street drugs. Few patients have been described worldwide, and those identified have ranged from asymptomatic to exhibiting neurocognitive changes.
And it is interesting that all of my symptoms began a month after i used the underground bodybuilding fat loss chemical DNP (Dinitrophenol) – 400mg per day for 2 weeks.
Can anyone shed some light on this?
I am happy you have improved.
First some clarification:
Folinic Acid = 5-formyl Tetrahydrofolate = one of the forms of folic acid. It doesn’t require dihydrofolate reductase for conversion to tetrahydrofolate.
Methylcobalamin = one of the forms of Vitamin B12. Methylcobalamin is one of the active forms of Vitamin B12. Cyanocobalamin is the most commonly purchased form. Cyanocobalamin is a synthetic form of B12, doesn’t occur in nature, and is converted to methylcobalamione or the other forms before it is used by the body.
P5P = Pyridoxal-5-phosphate = the active form of Vitamin B6. Pyridoxine is the most common form in B6 supplements.
Dinitrophenol is a metabolic poison that prevents ATP from being made in cells. ATP is the cellular storage form of energy. It is made when the energy stored in nutrients (such as glucose, proteins, fats) is oxidized in the mitochondria. When ATP production is blocked, the energy from nutrients is released instead as wasted heat. It was used in diet pills decades ago. But fatal overheating occurred. Apparently 20 mg/kg in humans can be lethal. It currently has industrial uses rather than medical uses.
I would wonder how much cellular damage can occur when cells become starved of ATP for metabolic activities. I would wonder about internal organ damage from overheating. The heat given off within the organs can’t readily be released into the air. I would wonder if localized overheating can then occur, causing tissue damage, particularly in parts of organs which don’t have as much vascularity as other parts.
Dr. M
@DrMariano 80 wrote:
I am happy you have improved.
First some clarification:
Folinic Acid = 5-formyl Tetrahydrofolate = one of the forms of folic acid. It doesn’t require dihydrofolate reductase for conversion to tetrahydrofolate.
Methylcobalamin = one of the forms of Vitamin B12. Methylcobalamin is one of the active forms of Vitamin B12. Cyanocobalamin is the most commonly purchased form. Cyanocobalamin is a synthetic form of B12, doesn’t occur in nature, and is converted to methylcobalamione or the other forms before it is used by the body.
P5P = Pyridoxal-5-phosphate = the active form of Vitamin B6. Pyridoxine is the most common form in B6 supplements.
Dinitrophenol is a metabolic poison that prevents ATP from being made in cells. ATP is the cellular storage form of energy. It is made when the energy stored in nutrients (such as glucose, proteins, fats) is oxidized in the mitochondria. When ATP production is blocked, the energy from nutrients is released instead as wasted heat. It was used in diet pills decades ago. But fatal overheating occurred. Apparently 20 mg/kg in humans can be lethal. It currently has industrial uses rather than medical uses.
I would wonder how much cellular damage can occur when cells become starved of ATP for metabolic activities. I would wonder about internal organ damage from overheating. The heat given off within the organs can’t readily be released into the air. I would wonder if localized overheating can then occur, causing tissue damage, particularly in parts of organs which don’t have as much vascularity as other parts.
Dr. M
Dr Mariano just to clarify i am well aware of what each of these compounds are.
I am only 20 but have spent a great deal of time researching and studying many subjects on health and am interested in studying a certain field in the near future.
The DNP use is what worries me the most. Which i regret to this day. All my symptoms did begin 1 month after i used it so it is something i am thinking about being the cause of all this.
From my ONE evaluation it seems i have elevated Nitric Oxide in my body and its converting to toxins instead of NO. Toxins (super oxide) and (peroxynitrite). Since both 5MTHFR and methylb12 reduce these toxins and also the fact that methylb12 regenerates the myelin sheath of nerves as well as prevents the accumulation of glutamate and those toxins damaging neurons it would explain why i am feeling so much better.
Do you think the excess NO could be of a infectious cause? Due to me having elevated Dihydrophenypropionicacid (DHPPA) on the test. I think this is linked to clostridium infection which doesn’t necessarily have to be in the gut but could have migrated elsewhere.
Also since all those supplements are methyldonors its certainly improving my undermethylated state also.
From all my testing the main things that i see wrong are:
Highly elevated Thyroid Peroxidase Antibodies – 2069 H (<50) should be under 50
Thyroid Globulin Antibodies – 60 (<50) H(my appetite is poor and i don’t eat anywhere as near as much for someone of my height and weight yet my weight tends to stay the same or go down a little bit, i can tell my metabolic rate is terrible)
T.S.H. – 5.7 (0.4 – 4.00) H
Free T4 – 14.7 (12 – 24)Low Total Testosterone: 10.1 (12 – 32) L
Low morning Cortisol saliva – 5 (5.3 – 45) LIGF-1: 33.5 * – low but doesn’t mention reference range.
I think my DHEA’s are low but not sure on exact lab ranges they are 4.5
Hair mercury – 2.4 (0.0 – 0.6) November 2008.
Hair Mercury 1.42 (<1.32) March/April 2009 after eliminating fish from diet and use of selenium/vitamin E, chorella, Intravenous Vitamin C 30g – 3-4 times.
Moderate Thoracic Kyphosis and compression of some discs. This is due to me doing weight training and bodybuilding exercises for about a year and a half and probably due to my low hormones my bones werent as strong to able to handle that weight.
I think that personally its just a complete hormonal disruption of my endocrine system causing all my symptoms. It runs in the family my father had hyper then hypo. Uncle had a Prolactin secreting pituitary tumor (prolactinoma) and hypothyroidism. Sister has low estrogen and low DHEA, mother has low estrogen and DHEA.
What do u think Dr. Mariano?
And do you have any idea on reference ranges on Insulin like growth factor – 1?
Im in australia by the way.
Thanks 🙂
I primarily wanted to clarify what the substances you mentioned were for our readers. Some may not be familiar with the acronyms used (such as P5P).
I have no idea about an infection as a cause of increased Nitric Oxide (NO). That would have to be assessed.
Nitric Oxide in the body is a neurotransmitter and hormone. It is a signal. Like any signal, it can be both good and bad depending on the circumstances.
In the brain, for example, it is used as a retrograde neurotransmitter. It travels from the dendrites of neurons to the axons of connecting neurons in order to strengthen the synaptic connection. This would be important, for example, in learning – where new synaptic connections are made.
Nitric Oxide is a signal used in the cardiovascular system to relax smooth muscle cells so that blood flow is increased and blood pressure is decreased. It is the signal that allows the penis to develop an erection.
The bad part about NO is it is also highly oxidizing. It can bind to the cobalt atom of Vitamin B12, for example, and inactivate B12. It can bind to the iron in hemoglobin. There are enzymes which rapidly destroy Nitric Oxide to control its destructive effects. But in excess, NO contributes to oxidative stress, which can lead to cell damage. Depending on the extent, excessive oxidative stress can lead to cell death.
@MetalMX 83 wrote:
Dr Mariano just to clarify i am well aware of what each of these compounds are.
I am only 20 but have spent a great deal of time researching and studying many subjects on health and am interested in studying a certain field in the near future.
The DNP use is what worries me the most. Which i regret to this day. All my symptoms did begin 1 month after i used it so it is something i am thinking about being the cause of all this.
From my ONE evaluation it seems i have elevated Nitric Oxide in my body and its converting to toxins instead of NO. Toxins (super oxide) and (peroxynitrite). Since both 5MTHFR and methylb12 reduce these toxins and also the fact that methylb12 regenerates the myelin sheath of nerves as well as prevents the accumulation of glutamate and those toxins damaging neurons it would explain why i am feeling so much better.
Do you think the excess NO could be of a infectious cause? Due to me having elevated Dihydrophenypropionicacid (DHPPA) on the test. I think this is linked to clostridium infection which doesn’t necessarily have to be in the gut but could have migrated elsewhere.
Also since all those supplements are methyldonors its certainly improving my undermethylated state also.
From all my testing the main things that i see wrong are:
Highly elevated Thyroid Peroxidase Antibodies – 2069 H (<50) should be under 50
Thyroid Globulin Antibodies – 60 (<50) H(my appetite is poor and i don’t eat anywhere as near as much for someone of my height and weight yet my weight tends to stay the same or go down a little bit, i can tell my metabolic rate is terrible)
T.S.H. – 5.7 (0.4 – 4.00) H
Free T4 – 14.7 (12 – 24)Low Total Testosterone: 10.1 (12 – 32) L
Low morning Cortisol saliva – 5 (5.3 – 45) LIGF-1: 33.5 * – low but doesn’t mention reference range.
I think my DHEA’s are low but not sure on exact lab ranges they are 4.5
Hair mercury – 2.4 (0.0 – 0.6) November 2008.
Hair Mercury 1.42 (<1.32) March/April 2009 after eliminating fish from diet and use of selenium/vitamin E, chorella, Intravenous Vitamin C 30g – 3-4 times.
Moderate Thoracic Kyphosis and compression of some discs. This is due to me doing weight training and bodybuilding exercises for about a year and a half and probably due to my low hormones my bones werent as strong to able to handle that weight.
I think that personally its just a complete hormonal disruption of my endocrine system causing all my symptoms. It runs in the family my father had hyper then hypo. Uncle had a Prolactin secreting pituitary tumor (prolactinoma) and hypothyroidism. Sister has low estrogen and low DHEA, mother has low estrogen and DHEA.
What do u think Dr. Mariano?
And do you have any idea on reference ranges on Insulin like growth factor – 1?
Im in australia by the way.
Thanks 🙂
I have followed people that have used DNP as it was a bodybuilding fade back in the 90’s with Dan Duchaine. Exactly how it impacts the body I am not sure of because every one system is different. When it comes in a box that is labeled dangerous material one would think people would really reconsider its usage. Obviously from your genetic predispostion over training, and undereating have stressed your body to the point that it effected your HPTA axis. Since there was a genetic issue involved I began to look at the environment that you were in when this occured. EMF as well as any intestinal infection can increase NO2. I have long known that adrenal fatigue could have been a result of a hidden intestinal infection or dysbosis that has been secreting No2 levels. High no2 levels can bind with cobalmine resulting in percious anemia. Its amazing that our hair analyisis almost match up to the T. Your hair analysis was low in lithium and also cobalt. No2 shuts down the methione synthase pathway and can cause upregulation to the CBS as the demand for glutathione is increased. Getting the methylation in check and dealing with adrenals and thyroid would be the main focus of your recovery.
@hardasnails1973 85 wrote:
I have followed people that have used DNP as it was a bodybuilding fade back in the 90’s with Dan Duchaine. Exactly how it impacts the body I am not sure of because every one system is different. When it comes in a box that is labeled dangerous material one would think people would really reconsider its usage. Obviously from your genetic predispostion over training, and undereating have stressed your body to the point that it effected your HPTA axis. Since there was a genetic issue involved I began to look at the environment that you were in when this occured. EMF as well as any intestinal infection can increase NO2. I have long known that adrenal fatigue could have been a result of a hidden intestinal infection or dysbosis that has been secreting No2 levels. High no2 levels can bind with cobalmine resulting in percious anemia. Its amazing that our hair analyisis almost match up to the T. Your hair analysis was low in lithium and also cobalt. No2 shuts down the methione synthase pathway and can cause upregulation to the CBS as the demand for glutathione is increased. Getting the methylation in check and dealing with adrenals and thyroid would be the main focus of your recovery.
I think so too. Thyroid in particular. Im pure hypo with the symptoms – inability to lose weight issues/weight simply stuck and in your face thyroid symptoms – chronic constipation, cold hands and feet, poor nail growth, hair falls out easily, muscle weakness and more.
I will probably start on armour and see how i go. I don’t respond well at all to synthetic T4/T3. I think i might be fine on armour or if not then it would be my low cortisol causing a thyroid dump of hormones into the blood and the hormone not being able to be taken up by the cells, since you need enough cortisol for that. So i will do both HC or isocort and Armour and i should be flying!
Hair analysis matchs up huh haha thats interesting, you and i have a very similar biochemistry and issues.
My mum has similar symptoms to me – i suspect she has hashi’s like me, and low B12 no doubt from the blood test which could be pernicious anemia. Going to do a blood test for her for those asap.
It is interesting that both my mum, sister and grandmother and i have numbness and tingling and slight sensation loss in fingers at times… indicative or B12 and/or Thyroid abnormalities.
What pisses me off the most is taking all these supplements and from what it looks like to me the nutrients arent being absorbed by the body.
Doesn’t that piss you off?
Plus my appetite being shitty and always craving fats like butter and coconut oil. I can’t stand much carbs at all i have a aversion to them for whatever reason, i thrive on protein/fat foods. Do you find this to be the case with you also hardasnails?
The methylation supplements have been the biggest help so far to myself.
The chronic constipation is probably a mix due to hypothyroidism and toxins from the infection slowing down the bowels.
@MetalMX 83 wrote:
Highly elevated Thyroid Peroxidase Antibodies – 2069 H (<50) should be under 50
Thyroid Globulin Antibodies – 60 (<50) H(my appetite is poor and i don’t eat anywhere as near as much for someone of my height and weight yet my weight tends to stay the same or go down a little bit, i can tell my metabolic rate is terrible)
T.S.H. – 5.7 (0.4 – 4.00) H
Free T4 – 14.7 (12 – 24)Low Total Testosterone: 10.1 (12 – 32) L
Low morning Cortisol saliva – 5 (5.3 – 45) LIGF-1: 33.5 * – low but doesn’t mention reference range.
I think my DHEA’s are low but not sure on exact lab ranges they are 4.5
Hair mercury – 2.4 (0.0 – 0.6) November 2008.
Hair Mercury 1.42 (<1.32) March/April 2009 after eliminating fish from diet and use of selenium/vitamin E, chorella, Intravenous Vitamin C 30g – 3-4 times.
Moderate Thoracic Kyphosis and compression of some discs. This is due to me doing weight training and bodybuilding exercises for about a year and a half and probably due to my low hormones my bones werent as strong to able to handle that weight.
I think that personally its just a complete hormonal disruption of my endocrine system causing all my symptoms. It runs in the family my father had hyper then hypo. Uncle had a Prolactin secreting pituitary tumor (prolactinoma) and hypothyroidism. Sister has low estrogen and low DHEA, mother has low estrogen and DHEA.
Thanks 🙂Look up Hashimoto’s Thyroiditis and the diagnostic criteria. It occurs in about 15% of people. The presence of Hashimoto’s Thyroiditis shifts the average TSH in the U.S. from about 1.0 to about 3.5 The upper end of the reference range for TSH moves up and down depending on the population that comes to a particular lab.
From a psychiatric point of view, I generally see behavioral problems (such as mood disorder) occur at a TSH of 2.0 and above, assuming that the nervous system can function reasonably well to monitor thyroid hormone.
The range for IGF-1 is about 126 to 382 ng/mL for 19-30 y.o. males.
IGF-1 is frequently used to monitor growth hormone since it lasts longer in the blood than growth hormone itself. The problem is that IGF-1 is also determined by multiple signals such as dopamine, norepinephrine, thyroid hormone, testosterone, DHEA, insulin. Thus a problem in IGF-1 may also mean problems with these other signals rather than growth hormone itself. Optimizing these other signals may raise IGF-1 to the point growth hormone replacement may not be needed. Where on the spectrum of IGF-1 does growth hormone need replacement is fairly arbitrary. Anti-aging specialists may start replacement at 250 ng/mL. I generally would not do so until it is much lower and only after optimizing the rest of the system to eliminate the non-growth hormone factors causing low IGF-1.
One factor that can cause multiple endocrine problems is Hemochromocytosis. After monitoring numerous patients for Ferritin, I am surprised at how frequently I encounter Hemochromocytosis in both men and women. Unless it is addressed, their mood and cognitive problem are treatment resistant. The vast majority of patients, however, tend to be suboptimal in iron, as part of the pathophysiology of their mental illness.
@MetalMX 87 wrote:
What pisses me off the most is taking all these supplements and from what it looks like to me the nutrients arent being absorbed by the body.
Doesn’t that piss you off?
Plus my appetite being shitty and always craving fats like butter and coconut oil. I can’t stand much carbs at all i have a aversion to them for whatever reason, i thrive on protein/fat foods. Do you find this to be the case with you also hardasnails?
The methylation supplements have been the biggest help so far to myself.
The chronic constipation is probably a mix due to hypothyroidism and toxins from the infection slowing down the bowels.
Yes the constipation is the biggest issue I have as well. It can not be rectified by magnesium, vitamin C, or any other means which makes me think that I may have neurotransmitter imbalance. My body seems to respond incredible to sam-e and also 5 htp, but i have stopped it for a few weeks to see if my body regulate itself, but obviously I thought wrong. I am going back to 5 htp and then if after going up slow constipation does not relieve then i will add back in sam-e. My body responds very good to apple cider vinegar. when i get a chance i am start using fresh lemon juice in the morning to get the bile going. I have been told from the start its in my gut. My biggest suspicion is dybiosis leading to adrenal and thyroid issue. Its amazing that methylation issues run hand and in in both thyroid and adrenal imbalances.
@hardasnails1973 89 wrote:
Its amazing that methylation issues run hand and in in both thyroid and adrenal imbalances.
A problem in medical thinking and science in general is what I call “The Problem of Occam’s Razor”. Occam’s Razor is the idea that the simplest answer is the best or correct answer to a problem. It leads people to search for the single source of one’s problem, a single explanation for one’s problem, or a panacea.
But what if the problem or condition is actually a complex condition? What if it has multiple coexisting simultaneous causes? Medicine and science actually have difficulty dealing with problems like this. It is very difficult to design studies with more than one or two variables, for example.
What about 20 or more – which is what I have to deal with all the time. What about 700+ – the approximate number of data items I have to gather when I evaluate a person. What is interesting about psychiatry is that every mental illness has multiple simultaneous causes. I deal with complex issues all the time.
A complex problem means a complex answer.
Some interventions may work but actually work indirectly. For example, increasing serotonin signaling via 5HTP or via a serotonin reuptake inhibitor (SSRI) may help improve bowel motility. Serotonin is one signal for bowel motility. However, increasing serotonin also reduces dopamine signaling. What if the actual problem is excess dopamine – which itself can cause constipation? If so, serotonin is an indirect way to reduce dopamine signaling.
What if the cause of adrenal fatigue is from excess norepinephrine signaling, which is a compensation for low thyroid hormone signaling?
Unraveling the layers of causality with the realization that things can have multiple causes is enlightening.
An interesting problem with the use of large amounts of Vitamin B12 is that B12 may act as a nitric oxide scavenger. This might cause depletion of nitric oxide signaling, resulting in hypertension and possibly erectile dysfunction since nitric oxide is an important signal in both conditions.
@DrMariano 88 wrote:
Look up Hashimoto’s Thyroiditis and the diagnostic criteria. It occurs in about 15% of people. The presence of Hashimoto’s Thyroiditis shifts the average TSH in the U.S. from about 1.0 to about 3.5 The upper end of the reference range for TSH moves up and down depending on the population that comes to a particular lab.
From a psychiatric point of view, I generally see behavioral problems (such as mood disorder) occur at a TSH of 2.0 and above, assuming that the nervous system can function reasonably well to monitor thyroid hormone.
The range for IGF-1 is about 126 to 382 ng/mL for 19-30 y.o. males.
IGF-1 is frequently used to monitor growth hormone since it lasts longer in the blood than growth hormone itself. The problem is that IGF-1 is also determined by multiple signals such as dopamine, norepinephrine, thyroid hormone, testosterone, DHEA, insulin. Thus a problem in IGF-1 may also mean problems with these other signals rather than growth hormone itself. Optimizing these other signals may raise IGF-1 to the point growth hormone replacement may not be needed. Where on the spectrum of IGF-1 does growth hormone need replacement is fairly arbitrary. Anti-aging specialists may start replacement at 250 ng/mL. I generally would not do so until it is much lower and only after optimizing the rest of the system to eliminate the non-growth hormone factors causing low IGF-1.
One factor that can cause multiple endocrine problems is Hemochromocytosis. After monitoring numerous patients for Ferritin, I am surprised at how frequently I encounter Hemochromocytosis in both men and women. Unless it is addressed, their mood and cognitive problem are treatment resistant. The vast majority of patients, however, tend to be suboptimal in iron, as part of the pathophysiology of their mental illness.
I highly appreciate your replies Dr Mariano. This is very informative for myself.
Im am quite sure i have hashimotos based on my symptoms and test results.
In regards to IGF-1 i think that with proper thyroid hormone replacement, cortisol replacement (if needed) and testosterone replacement my IGF-1 should rise to a decent level. Since i suffer from low (thyroid, DHEA’s, testosterone) it is no suprise that IGF-1 is as well.
I agree GH therapy would be a last resort.
Is it possibly that increasing NO production is the body’s attempt to improve circulation/vasodilation when hormonal activity is underactive?
It is my understanding Nitric Oxide is secreted by phagocytes of the immune system. Nitric oxide is secreted as an immune response and is toxic to bacteria, but it is also a free radical when as we know in excess amounts is highly oxidizing and increases oxidative stress and subsequently can damage DNA and cause disease.
Another thing i have had for a couple of years is tingling under my skin as if ants are their or something is running around under my skin. It can be anywhere on my body depending on the time. In my ONE evaluation it indicated i had high Beta Alanine and that was a marker for bacterial dysbiosis.
So would this then explain why i am getting tingling sensations?
@DrMariano 94 wrote:
An interesting problem with the use of large amounts of Vitamin B12 is that B12 may act as a nitric oxide scavenger. This might cause depletion of nitric oxide signaling, resulting in hypertension and possibly erectile dysfunction since nitric oxide is an important signal in both conditions.
I have never thought of it in that way. As always you bring a greater understanding in learning the diversity of human biochemistry. After 2-3 months we would retest the markers through the proper testing which revealed it the first time. As we see improvment one would start to come back down to a more reasonable maintence dosage. Methyl b-12 is a good glutamate scavenger as well which in many peoples biochemistry glutamine gets converted to glutamate at rapid rate in stressed conditions. Hydroxcobalmine form of b-12 seem to potentially more associated with nitric oxide scavenger, but I could be wrong. If one would sit and look at each individual form a specific nutrient and trying to analyze by going through days of non stop studies they would go insane. When every a study said one thing then there are 10 others that say something different. I can understand were Dr Mariano is coming from when you have a list of blood work, urine and salvia then try to connect the dots. Sometimes this process will take me 2-3 days of research to compile, but not alot of dr’s will spend that time. Drs usually spend a brief less then 10 minutes with clients and out the door they go. How can a dr gather sufficent information with in that amount of time to come with what the cause is? I prefer to take my time and research things to give the best suggestions possible to help that person get back on their feet in a conservative way. I always have an open mind when it comes to learning because no one knows everything.
I would simply take the presence of hypertension into account when determining how much Vitamin B12 to give. I would tend to avoid large doses if blood pressure goes up with B12 supplementation. Thus regularly monitoring blood pressure – is important.
@DrMariano 99 wrote:
I would simply take the presence of hypertension into account when determining how much Vitamin B12 to give. I would tend to avoid large doses if blood pressure goes up with B12 supplementation. Thus regularly monitoring blood pressure – is important.
Thank you Dr Mariano because I would have never thought that b-12 could affect ones blood pressure. In the majority of cases that I run into low blood pressure seems to be the biggest complaint due to the burnt out adrenals. I ran into an interesting old thread that really aroused my curosity to what transpired in my life that may have been the cause for my rapid decline in health over the years.
Stressed mother —> high cortisol levels –>
higher cortisol levels in the womb–>genetically predisposed towards stress* Neurotic mother screams and being a bitch during early childhood–> high cortisol levels in the child–>hippocampus shrinks–>further predisposition towards stress
*Trying to live up to neurotic mothers expectation–>more stress, GI issues GERD
*This entire background leads to poor self image–>kid start bodybuilding to impress/attract women.
Also To I would also like to have your thoughts on people that are over traning and the CNS. I see alot of young guys with low testoserone and low adrenals that are mainly athletes. I also suspect that are parents diets and lifestyles are starting to affect the childerns DNA some how may be by alteration in gene silencing. I am currently looking into this right now that how weaken genes are at the potential cause for autism due to babies being born of stressed mothers. Stress weakens one DNA, but i have not found the exact mechanism of how. Are our genetics starting to show reduced tolerance to stress from just these past 30-50 years? If that is the case what is it going to be like from 100 years from now?
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