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Interested parties might check out the following http://www.prohibitionkills.blogspot.com/ There are no google ads on it, so it is not a scam site. The blogger discusses what he and others call endorphin deficiency syndrome. There is a lot of interesting material and as you get to the bottom (most recent), he discusses LDN therapy. BTW, some of the links on the website are no longer operational but there is still plenty of info there. Any thoughts on this topic?
Depression that is resistant to treatment could use antidepressants that act on more than one antidepressant or combination medication,plus or minus counselling.There are very important and central interrelations between reward,opiates, dopamine, and inflammatory or immune signalling.
I was very depressed on and off since I can remember and have been on several different anti-depressants over the years with little or no relief of everyone. Now, since I’m on methadone, I feel like a totally different person.I found it in an attempt to understand my own problems and believe me, this is not an attempt to try to justify using a drug. The ideal solution is to find something that can mimic mental benefits that people get of opiates, without the problems of addiction tolerance, and of course with respiratory failure.
@Gardiner 2207 wrote:
Interested parties might check out the following http://www.prohibitionkills.blogspot.com/ There are no google ads on it, so it is not a scam site. The blogger discusses what he and others call endorphin deficiency syndrome. There is a lot of interesting material and as you get to the bottom (most recent), he discusses LDN therapy. BTW, some of the links on the website are no longer operational but there is still plenty of info there. Any thoughts on this topic?
Some patients have dysfunction in endorphin signaling. This can lead to depression and other mental illnesses, and potentially drug abuse.
Assessing this signaling is difficult. Testing is nonexistent.
Often, the usual suspects (e.g. problems with neurotransmitter, endocrine, cytokine signaling, metabolic and nutritional deficiencies), have to be first considered and addressed in order to establish the basis for considering a opiate-related treatment unless the person already has an ongoing opiate or other drug addiction.
Buprenorphine and naloxone (Suboxone) is an option in such a treatment. There are many people who have significantly improved in mood and functioning with Suboxone, for example, when the usual psychiatric medications have failed.
Treatments with other opiates are difficult in long-term treatment due to tolerance and the potential for abuse. Long-term treatment is complicated by an increase in inflammatory cytokine signaling from brain neuroglial cells. Low dose naltrexone – such as with Suboxone – helps reduce these risks.
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