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Dr Mariano can you give me some information on what my results mean exactly? and what could be the cause of this?
Thank you.
I did a Non-contrast CT Brain scan.
Findings: The pineal gland is midline in position. The ventricles are of normal dimensions and are arranged symmetrically about the midline. There is normal differentiation between grey-white matter.
There is a abnormal widening of the sulci in both parietal lobes at the vertex – is their a history of substance use?
No obvious intracerebral space occupying lesion is demonstrated. A small sized pituitary gland is present. No abnormality is seen in the brain stem. The cerebellum appears normal.
No obvious abnormality detected in the region of the periventricular white matter.
CONCLUSION:
* Cortical atrophic changes in both parietal lobes at the vertex, abnormal for the patient’s young age. Is their a history of substance use?
* No space occupying lesion
@MetalMX 991 wrote:
Dr Mariano can you give me some information on what my results mean exactly? and what could be the cause of this?
Thank you.
I did a Non-contrast CT Brain scan.
Findings: The pineal gland is midline in position. The ventricles are of normal dimensions and are arranged symmetrically about the midline. There is normal differentiation between grey-white matter.
There is a abnormal widening of the sulci in both parietal lobes at the vertex – is their a history of substance use?
No obvious intracerebral space occupying lesion is demonstrated. A small sized pituitary gland is present. No abnormality is seen in the brain stem. The cerebellum appears normal.
No obvious abnormality detected in the region of the periventricular white matter.
CONCLUSION:
* Cortical atrophic changes in both parietal lobes at the vertex, abnormal for the patient’s young age. Is their a history of substance use?
* No space occupying lesion
is their a history of substance use?
@JanSz 993 wrote:
is their a history of substance use?
No. If by substance you mean cocaine, speed or any other type of drug in that category.
I did however use injectable anabolic steroids in 2008 although i did not know of the contents of the steroids meaning i didn’t know if they we’re 100% legitimate. With use i experienced severe side effects which means they were definitly not the steroids i thought they we’re.
I also used clenbuterol on and off in the past. I don’t know if clenbuterol has any effects on the brain. Also Dinitrophenol which is a bodybuilding fat loss drug.
One thing i noticed in my optimal nutritional evaluation Jansz is i had extreme glutamate levels of 73 (0-15) meaning their is neurotoxicity or excitotoxicity occuring… could this be due to hormonal deficiencies or genetic predispositions i don’t know.
I have started to take GABA before bed to blunt the high glutamate levels. This has helped me to be able to sleep better and wake up less as i have a problem of constantly waking up.
I have just begun 50mcg of T4 in the evening and feeling much better than before mentally as well as physically. For some reason if i take it in the morning i feel much much worse where as if i take it at night i feel good.
I would like Dr Mariano’s opinion on this. And are their any over the counter supplements which can contribute to cortical atrophy possibly…
The past few months i have been using:
Calcium 500mg per day
Magnesium 500mg per day
B Vitamin Complex 1 per dayProbiotics
Zinc formula with Molybdenum (15mg zinc, 150mcg molybdenum, 20mg manganese, 200mcg chromium) 1 per day
Glutathione transdermal cream probably gone through about 4 bottles of 10g each (made of cysteine, glutamine and glycine), i have cystinuria and i just read substancial glutathione useis contraindicated in cystinuria, again not sure on the effects this could have.
Last 7 weeks:
Methylcobalamin 10mg per day
Folinic Acid 4mg per day
P5P 50mg per dayNothing crazy in terms of a supplement schedule. But i have stopped using everything and just evaluating where i am at the moment. The Methylcobalamin and folinic acid if i take it now seems to produce these god awful feelings of being really unwell mentally.
@MetalMX 991 wrote:
I did a Non-contrast CT Brain scan.
Findings: The pineal gland is midline in position. The ventricles are of normal dimensions and are arranged symmetrically about the midline. There is normal differentiation between grey-white matter.
There is a abnormal widening of the sulci in both parietal lobes at the vertex – is their a history of substance use?
No obvious intracerebral space occupying lesion is demonstrated. A small sized pituitary gland is present. No abnormality is seen in the brain stem. The cerebellum appears normal.
No obvious abnormality detected in the region of the periventricular white matter.
CONCLUSION:
* Cortical atrophic changes in both parietal lobes at the vertex, abnormal for the patient’s young age. Is their a history of substance use?
* No space occupying lesion
Abnormal widening of the sulci on both parietal lobes / cortical atrophic changes indicates there is abnormal loss of brain mass in the indicated areas – a process called atrophy.
The question would then be: does this represent loss of brain cells / brain cell death or loss of myelination (the insulation around nerve axons that speeds up neuron electrochemical signals). This would depend on the condition a person has.
For example, as people age, there is progressive loss of brain cells or myelination which results in shrinkage of brain mass. If the shrinkage is too large or quick, then a degenerative illness such as Alzheimer’s disease would be suspected.
In the illness, schizophrenia, there is loss of brain mass in the frontal cortex. But so far, no loss of brain cells has been found. Rather, there is loss of myelination or connections between brain cells accounting for shrinkage in the brain.
Some drugs, such as alcohol, are toxic to the brain. This can lead to the death of brain cells and shrinkage of the brain.
Some infections, such as herpes, may affect the brain, resulting in loss of brain cells and brain mass.
A neurologist may need to be consulted to help determine what is occurring. Neurologists, more than other physicians, specialize in determining the causes of structural changes in the brain.
@DrMariano 1017 wrote:
Abnormal widening of the sulci on both parietal lobes / cortical atrophic changes indicates there is abnormal loss of brain mass in the indicated areas – a process called atrophy.
The question would then be: does this represent loss of brain cells / brain cell death or loss of myelination (the insulation around nerve axons that speeds up neuron electrochemical signals). This would depend on the condition a person has.
For example, as people age, there is progressive loss of brain cells or myelination which results in shrinkage of brain mass. If the shrinkage is too large or quick, then a degenerative illness such as Alzheimer’s disease would be suspected.
In the illness, schizophrenia, there is loss of brain mass in the frontal cortex. But so far, no loss of brain cells has been found. Rather, there is loss of myelination or connections between brain cells accounting for shrinkage in the brain.
Some drugs, such as alcohol, are toxic to the brain. This can lead to the death of brain cells and shrinkage of the brain.
Some infections, such as herpes, may affect the brain, resulting in loss of brain cells and brain mass.
A neurologist may need to be consulted to help determine what is occurring. Neurologists, more than other physicians, specialize in determining the causes of structural changes in the brain.
Thank you so much.
I am about to see a neurologist for this. Since i took the thyroxine 50mcg everynight i feel much better. I have a suspicion that this has been caused by hypothyroid neuropathy and nerve damage. I experienced muscle weakness more severe, slight hearing loss and feeling mentally unwell, tingling on the back of the head and down the spine, difficulty speaking, face swelling, hands cold as ice.
What other hormones are critical for myelin development?
My blood test results will tell the story.
@MetalMX 1024 wrote:
Thank you so much.
I am about to see a neurologist for this. Since i took the thyroxine 50mcg everynight i feel much better. I have a suspicion that this has been caused by hypothyroid neuropathy and nerve damage. I experienced muscle weakness more severe, slight hearing loss and feeling mentally unwell, tingling on the back of the head and down the spine, difficulty speaking, face swelling, hands cold as ice.
What other hormones are critical for myelin development?
My blood test results will tell the story.
Myelination is not so much about hormones as about nutrition.
Myelin is formed primarily from cholesterol and saturated fat. Vitamin B12 is one of the signals that helps form myelin. Vitamin B12 primarily is available in animal fat.
When one looks at mother’s milk, one finds that it is high in saturated fat and cholesterol. Eggs are similarly stocked.
Saturated fats and cholesterol make up the bulk of the brain.
The fats and the nutrients in fats (such as Vitamin A and B12) are important for the development of the brain.
In fact, half of the dry weight of the human brain is cholesterol.
Interestingly, the brains of vegetarians are smaller than the brains of people who are more omnivorous.
@DrMariano 1029 wrote:
Myelination is not so much about hormones as about nutrition.
Myelin is formed primarily from cholesterol and saturated fat. Vitamin B12 is one of the signals that helps form myelin. Vitamin B12 primarily is available in animal fat.
When one looks at mother’s milk, one finds that it is high in saturated fat and cholesterol. Eggs are similarly stocked.
Saturated fats and cholesterol make up the bulk of the brain.
The fats and the nutrients in fats (such as Vitamin A and B12) are important for the development of the brain.
In fact, half of the dry weight of the human brain is cholesterol.
Interestingly, the brains of vegetarians are smaller than the brains of people who are more omnivorous.
The my brain should be cracking out of skull 😛
I am a meat eater and a protein/fat type of person. I cannot eat many carbohydrates they don’t work well with me in terms of giving me energy and giving me digestive upsets.
I have posted my blood tests results in my Thyroid autoantibodies thread in the hormones section.
Is their any possibility that mercury toxicity can cause Posterior cortical atrophy?
I have had elevated levels on hair analysis.
On my analysis it says:
Inorganic mercury concentrates mostly in kidneys, while organic (methyl) mercury has high affinity for the posterior cortex of the brain.
Your thoughts Dr Mariano?
@Mebigusmall 2277 wrote:
where are you getting all the mercury from?
It was from a previous bodybuilding escapade in which i spent 2 years eating tones of canned tuna almost everyday.
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