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Thera are many factors that decrease the level of catecholamines. In aging, the signal dopamine begin to go down.
What the best way to improve brain DA function with aging when you thyroid, testosterone, cortisol level is optimum ?
Myself suffer from low level of brain DA and probably low brain NE.
I’ve trying many supplement : vit B complex, folic acid, tyrosine, DL phenyalanine, tyrosine, mucuna pruriens. I don’t have great result
When I take coffee or nicotine gum I feel good for a moment with a down in the day, specially nicotine gum.
Deprenyl, nothing great.
The best result come from ritalin 10 mg. I feel GREAT all the day with a depleted brain the next morning (probably by brain catecholamine depletion !!!)
With my physician I try the mix ritalin 10 mg with 300 mg of moclobemide (IMAOa reversible). I don’t have the bad feeling of depleted brain the next morning. I don’t have the same effect with ritalin/deprenyl.
My question : I feel NORMAL with the mix of low dose of ritalin/moclobemide, do there are side effect with time with this drugs, like addiction, down regulation of catecholamines synthesis, brain inflammation, oxydation, acidification, neuronal detoriation ?
Do you have a better way to improve the brain catecholamines function ?
THANK YOU
@Jean 1182 wrote:
Thera are many factors that decrease the level of catecholamines. In aging, the signal dopamine begin to go down.
There are only about 50,000 dopamine neurons in the brain. They die off as we age. In illnesses such as Parkinson’s Disease, they die off sooner.
What the best way to improve brain DA function with aging when you thyroid, testosterone, cortisol level is optimum ?
There is no one best way to improve dopamine signaling. This has to be customized to the person.
One can try to preserve their dopamine neurons by using antioxidants and other neuroprotective substances.
When depressed, one may have a reduction in dopamine production in order to raise norepinephrine production. Treating depression would help restore dopamine production.
Myself suffer from low level of brain DA and probably low brain NE.
It is difficult to have low brain norepinephrine while awake. Norepinephrine is the primary signal for wakefulness. If one is anxious or irritable, one has high norepinephrine signaling. If one feels stressed, one has high norepinephrine signaling. Norepinephrine maintains blood pressure. Thus if one is able to stand, one probably has adequate production of norepinephrine.
I’ve trying many supplement : vit B complex, folic acid, tyrosine, DL phenyalanine, tyrosine, mucuna pruriens. I don’t have great result
When I take coffee or nicotine gum I feel good for a moment with a down in the day, specially nicotine gum.
Deprenyl, nothing great.
The best result come from ritalin 10 mg. I feel GREAT all the day with a depleted brain the next morning (probably by brain catecholamine depletion !!!)
With my physician I try the mix ritalin 10 mg with 300 mg of moclobemide (IMAOa reversible). I don’t have the bad feeling of depleted brain the next morning. I don’t have the same effect with ritalin/deprenyl.
I am happy you and your physician found a solution.
It is unfortunate that the company making Moclobemide would not pay the $250 million fee (for adequate clinical trials, etc.) to get FDA approval so it would be available in the United States.
Note that MAO Inhibitors primarily raise Serotonin, then norepinephrine and dopamine. The increase in serotonin helps balance the rise in norepinephrine from Ritalin (which causes stress, can cause HPA Axis dysregulation and the loss of cortisol production – which makes a person feel depleted).
My question : I feel NORMAL with the mix of low dose of ritalin/moclobemide, do there are side effect with time with this drugs, like addiction, down regulation of catecholamines synthesis, brain inflammation, oxydation, acidification, neuronal detoriation ?
Do you have a better way to improve the brain catecholamines function ?
THANK YOU
Everyone has difference in response to various treatments. Thus there is not one best way to improve brain function. It still has to be customized to the person.
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DEPENDENCE: the repeated use of a substance such that a person, when stopped, develops withdrawal signs and symptoms.
ADDICTION: the repeated use of a substance such that a person becomes impaired in function. The substance usually causes dependence.
MEDICINAL USE OF A SUBSTANCE: The repeated use of a substance such that a person becomes improved in function. The substance may cause dependence (which is not addiction).
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Every repeatedly used substance may cause dependence. For example, aspirin causes dependence with repeated use. The withdrawal sign may be a migraine-like headache.
Dependence must be distinguished from addiction.
Addiction is generally not acceptable since it causes dysfunction.
The medicinal use of a substance that causes dependence is acceptable given the improvement in function.
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See the prescribing information and the literature (e.g. search Medline) for possible risks with Ritalin and Moclobemide. The benefits of long-term treatment are weighed against the risks.
Psychiatric medications such as the stimulants and antidepressants are generally used long-term.
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