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First of all, when we discuss DHEA as a sublingual, I assume we’re talking about a liquid suspension which requires very low volume, i.e. 1 – 2 drops under the tongue. The sublingual lozenges can wind up getting swallowed and negate the benefit (or difference, depending) of the sublingual, which is bypassing first pass metabolism.
Oral – easy to use, more readily converts to E2 (??) than T
Transdermal – ease of use, more readily converts to T (??) than E2, reputed to actually decrease serum DHEA levels (??). What does the release / peak / half life look like?
Sublingual – also bypasses first pass; pks?? dosing?? use with DMSO as oral??
Can anybody recommend a good TD DHEA product? Hardasnails, what product did you use?
Also, if someone is already using transdermal pregnenolone, can one be applied over the other? Or would that cause interference (biochemistry is not my thing).
@chaos 42 wrote:
Also, if someone is already using transdermal pregnenolone, can one be applied over the other? Or would that cause interference (biochemistry is not my thing).
Generally, with a transdermal product, it is important to apply as thin a film as possible since only the product closest to the skin surface will get absorbed. Once the carrier dries, the remaining product is not absorbed.
Sometimes, such as with estradiol, which is difficult to absorb, one also have to rub it in several times to encourage absorption.
Interference can occur when layering another product over another, particularly if the other product is already dry. The carrier cream or gel would interfere – particularly if they are different in composition or if they are dry. It would be best to apply the product on a different, newly cleaned patch of skin.
The higher the concentration of a product – as long as it doesn’t precipitate too easily – the smaller the area of skin that is used.
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