Could you have Pyroluria?

[MetalMX]

I am wondering how many people actually have this disorder.

I am getting tested for this since i believe my consistent low zinc could be causing this even though i was supplementing with large amounts. I also showed low B6 levels through nutritional testing as lack of ability to convert B6 to the active form P5P.

My sister also has this condition confirmed through urine testing and their is has a tendency to run in families.

I am wondering if other people on this board could possibly have this disorder yet not know about it.

Lack of B6/P5P would cause low serotonin and this would put the person in a state of depression and poor moods. Zinc depletion would cause low testosterone, poor sperm quality, poor appetite, smell and taste loss.

Pyroluria is a genetically determined chemical imbalance involving an abnormality in hemoglobin synthesis. Hemoglobin is the protein that holds iron in the red blood cell. Individuals with this disorder produce too much of a byproduct of hemoglobin synthesis called “kryptopyrrole” (KP) or “hemepyrrole.” Kryptopyrrole has no known function in the body and is excreted in urine.

Kryptopyrrole binds to pyridoxine (vitamin B6) and zinc and makes them unavailable for their important roles as co-factors in enzymes and metabolism. These essential nutrients when bound to kryptopyrrole are removed from the bloodstream and excreted into the urine as pyrroles. Arachidonic acid (an omega-6 fatty acid) also becomes deficient.

Common emotional and physical characteristics of pyroluria.

Little or no dream recall
White spots on finger nails
Poor morning appetite and/or tendency to skip breakfast
Morning nausea
Pale skin, poor tanning or burn easy in sun
Sensitivity to bright light
Hypersensitive to loud noises
Reading difficulties (e.g. dyslexia)
Histrionic (dramatic)
Argumentative/enjoy argument
Mood swings or temper outbursts
Much higher capability & alertness in the evening, compared to mornings
Anxiousness
Preference for spicy or heavily flavored foods
Abnormal body fat distribution
Significant growth after the age of 16

Anyone having these similar symptoms should have the urine test done to check for this disorder.

[hardasnails1973]

@MetalMX 2076 wrote:

I am wondering how many people actually have this disorder.

I am getting tested for this since i believe my consistent low zinc could be causing this even though i was supplementing with large amounts. I also showed low B6 levels through nutritional testing as lack of ability to convert B6 to the active form P5P.

My sister also has this condition confirmed through urine testing and their is has a tendency to run in families.

I am wondering if other people on this board could possibly have this disorder yet not know about it.

Lack of B6/P5P would cause low serotonin and this would put the person in a state of depression and poor moods. Zinc depletion would cause low testosterone, poor sperm quality, poor appetite, smell and taste loss.

Pyroluria is a genetically determined chemical imbalance involving an abnormality in hemoglobin synthesis. Hemoglobin is the protein that holds iron in the red blood cell. Individuals with this disorder produce too much of a byproduct of hemoglobin synthesis called “kryptopyrrole” (KP) or “hemepyrrole.” Kryptopyrrole has no known function in the body and is excreted in urine.

Kryptopyrrole binds to pyridoxine (vitamin B6) and zinc and makes them unavailable for their important roles as co-factors in enzymes and metabolism. These essential nutrients when bound to kryptopyrrole are removed from the bloodstream and excreted into the urine as pyrroles. Arachidonic acid (an omega-6 fatty acid) also becomes deficient.

Common emotional and physical characteristics of pyroluria.

Little or no dream recall
White spots on finger nails
Poor morning appetite and/or tendency to skip breakfast
Morning nausea
Pale skin, poor tanning or burn easy in sun
Sensitivity to bright light
Hypersensitive to loud noises
Reading difficulties (e.g. dyslexia)
Histrionic (dramatic)
Argumentative/enjoy argument
Mood swings or temper outbursts
Much higher capability & alertness in the evening, compared to mornings
Anxiousness
Preference for spicy or heavily flavored foods
Abnormal body fat distribution
Significant growth after the age of 16

Anyone having these similar symptoms should have the urine test done to check for this disorder.

When given my supplement recommendation for my clients all this is already factored in to there nutritional recommendations. I use dream recall as a way to know if they are reaching a good rem sleep and where a good dosage of vitamin zinc, and b-6 is reached. Manganese is also low in these disorder as well which could explain why low cholesterol is common in stress cases. When hair analysis are ran low cholesterol and manganese are highly correlated.

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