beyond all help? thyroid/adrenal issues

[sarah1364]

I would please like some input.
I am 24 y/o female. Both parents are hypothyroid, mother hashimoto’s while pregnant with me, father graves then turned hypo. All my sisters, grandparents on both sides, hypo. My brother just got dx with hashimotos at 28.

Anyways, I began having symptoms very young, I used to have a period for 3 weeks.
I have always been cold and constipated, my skin turned very pale at 14, depressed, etc. the usual hypo stuff. I have always felt sick, spent a lot of time in the hospital, rashes, just random stuff.

anyways, I had such a hard time losing weight. I began exercising 6-7 hours a day when I was 17 and eating less, but still carbs/fats/protein. When I was 18/19, I began doing about 2 hours of cardio a day and an hour of weight lifting. zero carbs or added fats, just egg whites, chicken, extra lean turkey, fat free cottage cheese, tuna. nothing else. I began competing in bikini/figure shows, lost tons of weight. My schedule was this: wake up at 4:00, study for a bit, train, go to school until about 5, work at my job, sometimes I would train 2xs a day. This continued until I went to grad school in another state and really felt the drain.. I didn’t have a period for 8 years. Here are some of my labs..

May 2009:
Cortisol Basal 11.1
Cortisol Reference Range: AM = 3.4-26.9, PM = 0.9-15.8
Cortisol 30 min 24.6
Cortisol 60 min 25.3
ACTH 14 8-42 pg/mL done at 11, in another city, stressful drive

ACTH, plasma 5 2008

TSH, 3rd generation 1.67 (ref. range .40-4.50)
t-4, free .8 (ref range .8-1.8 )
Cortisol 10.3 (4.0-22)
t3, free 154L (230-420)
Glucose, 50
Thyroglobulin <20 (range says <20 IU/mL)
Thyroid Peroxidase <10 (range <35 IU/mL)
t3, reverse 25 (11-32) may 2008

TPO <10 (range <35)
T4, Free .9 (.8-1.8)
TSH 1.96 (.40-4.50)
T3, Free 240 (230-420) Sept 2009

Sex hormones, blood:
FSH 16.0 Ref. Range: Follicular 2-11 Luteal 1-9 Post-meno 20-100
Estradiol 17B <12 Ref. Range: Early Foll. = 20-82, Late Foll. = 80-378, Luteal = 50-150, Post
menopause = <30.
DHEA-S 88.9 ref. range: 41.0-247.0 ug/dL
LH 1.3 Ref range: Foll. 1-12 Luteal 1-10 Post-meno >20
Prolactin 2.5 ref.range: 2.0-17.4 ng/mL
Testosterone 34 ref. range: 20-70 ng/dL
Testosterone Free % 1.1 ref. range: 0.3-1.9 %
Testosterone Free 3.9 ref.range: 1.0-9.0 pg/mL
all done day 3 of cycle

dr gave me a GNRH stim test:
LH Basal 5.3
FSH Basal 8.7
LH 30 min 17.0
FSH 30 min 12.3
LH 60 min 19.9
FSH 60 min 14.1
LH, 120 min 22.7
FSH, 120 min 16.6

august 09
24hr cortisol saliva:
A: 3.9 (ref range 3.7-9.5)
B: 2.5 (1.2-3.0)
C: 1.5 (.6-1.9)
D: .9 (.4-1.0) want to redo this before starting h/c as it was in august

August 09, saliva
estradiol 1.1 (ref range 1.3-3.3)
Progesterone 67 (75-270)
Ratio pg/E2 61 (Optimal 100-500 wen E2 1.3-3.3)
Test, 12 (16-55)
dhea 4.9 (2-23)

dr gave me this for my hormones:
Test: .6 strength, 1 mL in the AM. Cream. 6 days out of 7 per week.
Estrogen: Biest, cream. the tube says “.1(1:1) MG/ML” I was to use 1mL in the AM 6 days out of 7.
Dhea: bhrt, 5 mg every day in the AM pill
Progesterone: pill form, 100 mg each. Directions: 1 hr before bed take 1 pill on days 5-11 of cycle; 1 hr before bed take 2 pills days 12-26 of cycle.
gained weight, went crazy, punched holes in wall, severe depression, suicidal on these bhrt. went off them.

dr then gave me cortef 15-20 mg I was on for 2 months and I had bad reactions to it, gained weight, stretch marks, glucose issues, etc. however, mentally it was the best I have ever felt in my life.

sorry, this is SO long.
anyways, heres my new thyroid labs:
tsh: 2.940
t4, free: .81 (.82-1.77)
Reverse t3: 195 (90-350)
t3, free 2.1 (2.0-4.4)

dr put me on compounded t3/t4. 50 mcg t4, 1mg SR t3. very depressed, fatigued, bloated, constipated. found out it was the cellulose. after 1 and a half week on the meds my labs were:

tsh 1.460 (.450-4.500)
t3, free 1.9 (2.0-4.4)
t4, free .93 (.82-1.77)
finally have ERFA on the way..

am I beyond help? anyone have any input at all?? thank you for your help and reading this looong post!

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