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What kind of effects do Benzodiazepines have on the body? What about hormones? Someone mentioned to me that some benzo’s have peripheral effects while others do not ; and also mentioned that some like to build up in the heart. Im also curios as to how long one can expect their benzo tolerance to go down. Say someone was taking 1mg of klonopin for 1 year…… what would be a rough estimate as to how long their tolerance would last?
@The450Man 619 wrote:
What kind of effects do Benzodiazepines have on the body? What about hormones? Someone mentioned to me that some benzo’s have peripheral effects while others do not ; and also mentioned that some like to build up in the heart. Im also curios as to how long one can expect their benzo tolerance to go down. Say someone was taking 1mg of klonopin for 1 year…… what would be a rough estimate as to how long their tolerance would last?
Benzodiazepines increase sensitivity of neurons to GABA, the primary inhibitory signal in the brain. Benzodiazepines reduce the activity of nearly every cell in the brain. This then can, if the dose is high enough, impair production of very signal produced. This in turn can produce affects on the rest of the body.
The primary target of increasing GABA signaling by using Benzodiazepines is to reduce excessive norepinephrine signaling.
Tolerance – meaning reduce effectiveness – can occur to Benzodiazepines. Generally, the production do GABA receptors is reduced with treatment. Usually, there is enough of an effect left, that Benzodiazepines can be used over a long time – years and years. But the higher the dose and the shorter the duration of action, the greater the tolerance for the Benzodiazepine.
Each person has their own personal response to each Benzodiazepine. It is good that there are many to choose from to find which one works the best.
Long-acting benzodiazepines can build up in the body to the point of continuously sedating a person, which can seriously impair function if the build-up is too high. For example, Diazepam can last up to 100 hours in an elderly person.
It is important to look at the physician’s prescribing information for each benzodiazepine to compare side effects of each. Sometimes there are unusual side effects in patients – such as unexpected weight gain.
so, the way the body builds a tollerence to Benzodiazepines is throuh the reduction of gaba receptors? reducing gaba itself? reduction of Benzodiazepines binding sites?
In the past i have used Benzodiazepines (klonopin) for a year straight at .5 to 1mg daily. I have been off it for about a month now. I did take 1mg when i went out to make me more comfortable and felt very little of an effect. Im assuming its because when i took it in the past, it was building up in my system due to the long half life. So i guess its safe to say i had more then 1mg in my system daily which would explain my tollerence to the 1mg. When i first took it, .5 would knock me on my ass. The days after i took it i was very depressed, anxious, and just felt like crap as a whole. Can this be from some kind of withdrawl?
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