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I use arimidex as part of my regimen. I hear some prefer aromsin (sp?). Is one better than the other for TRT, especially as it relates to mood?
Before I used the arimidex, I was very moody, but the arimidex resolved that.
@chaos 238 wrote:
I use arimidex as part of my regimen. I hear some prefer aromsin (sp?). Is one better than the other for TRT, especially as it relates to mood?
Before I used the arimidex, I was very moody, but the arimidex resolved that.
Aromasin irreversibly binds to aromatase, knocking out the enzyme completely. Adjusting dose can be trickier than with Arimidex since the enzyme it binds to is completely inactivated. It is easy to knock out almost all of estradiol by having too large a dose with Aromasin. It is almost all excreted in about a week. Lowering estradiol dose excessively can bring about low estrogen problems including reduced libido, hot flashes, increased cholesterol, etc.
Arimidex competes with testosterone for binding to aromatase. Adjusting its effect involves increasing or decreasing the dose to get the desired binding effect on Aromatase to increase or decrease estradiol levels. The problem for Arimidex is that the duration of action very long. It takes up to 6 weeks to stabilize the dose and level of estradiol.
Both are very expensive medications. Aromasin has to be taken every day since its duration of action is much shorter than Arimidex. Arimidex can be taken once a week to keep stable blood levels.
I can’t vouch for one or the other. Arimidex seems to be the one chosen by most practitioners. The ability to avoid daily dosing is a nice feature of Arimidex once steady levels of estradiol are established. One can, for example just take it on the day of a testosterone injection.
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