All over muscle twitching, buzzing, crawling sensations, what can be the cause?

[gu3vara]

I’m working on balancing my hormones right now, having low T, hashimoto and low adrenals but I remain quite desperate with my muscle problems, they are stiff, they cramp very often and there is almost always one muscle that twitch somewhere (I’d say light twitches, not apparent to others)…

I also have low ferritin and B12 levels and I’m taking magnesium which doesn’t seem to help.

I noticed a lot more cramping after I switched to Armour, my TSH went up to 12 on one grain and I’m now at 2 grains and symptoms remain. I’m going to get all the thyroid panel done next week to see where I’m at. Should I test total T3 with Ft4 Ft3 and TSH to have a clearer picture maybe?

Should I look somewhere else for those muscle problems? Lyme, Celiac etc…? I have a clean EMG btw, no neuropathy.

Thx for the input

[hardasnails1973]

@gu3vara 609 wrote:

I’m working on balancing my hormones right now, having low T, hashimoto and low adrenals but I remain quite desperate with my muscle problems, they are stiff, they cramp very often and there is almost always one muscle that twitch somewhere (I’d say light twitches, not apparent to others)…

I also have low ferritin and B12 levels and I’m taking magnesium which doesn’t seem to help.

I noticed a lot more cramping after I switched to Armour, my TSH went up to 12 on one grain and I’m now at 2 grains and symptoms remain. I’m going to get all the thyroid panel done next week to see where I’m at. Should I test total T3 with Ft4 Ft3 and TSH to have a clearer picture maybe?

Should I look somewhere else for those muscle problems? Lyme, Celiac etc…? I have a clean EMG btw, no neuropathy.

Thx for the input

When my estrodial goes too high this will cause uncontrollable muscle twitching. The mechanism that this may occur would be the estrodial which could be blocking thyroid signaling by increasing TBG. Some times its hard to distinguish high e2, low cortisol, or low thyroid. Hormonal imbalance is potentially causing an imbalance in the influx of calcium and magnesium with in the cell. I know when cortisol goes low this can cause the body not to hold on to magnesium which could result in muscle spasms. I have seen this happen in many people that take 1000 mgs of magnesium a day and still end up deficient. Once the adrenals are addressed then their magnesium deficiency will be resolved. This is what I believe to be known as a refractory magnesium deficiency. If yourTSH is going up then you are not properly using your thyroid medicine for the fact of low cortisol and low ferritin levels. I have a guy that is on 400 mcgs of t-4 and has tsh of 200. After his cortisol levels came back at 3.9 and his ferritin level at 20 this would explain why. The fact taking 11 mgs of melatonin and being on 200 mgs of testosterone with out checking his levels for over a year had a huge impact of his hormonal balance. When you are feeling these symptoms is perfect opportunity to check a lab work done as it could possible give a reason to why these are occuring.

[gu3vara]

I happen to have low levels of estrogens, low DHEA, low cortisol, low thyroid and low T.

I’m on 25 mg HC since march and I noticed I was able to take thyroid meds without feeling totally hyper, that’s new to me and it’s a good start.

I started T shots recently and increased DHEA, I wonder what my estrogen levels will look like on the next test. I started taking iron fumarate 100 mg too to address my low ferritin and taking B12 shots every 2 weeks now.

I’ll update this thread my next thyroid results, next week. I have the feeling I will have odd results again. I experienced high normal FT3, high normal FT4 and high TSH in the past that totally confused my endo back then, now I realize it was probably pooling. Funny thing is that I took Effexor two times in the past and that impacted my TSH that moved from 6 to around 2 quite fast.

I just wonder if I’m missing something in the big picture, that could cause pooling and muscle issues.

[DrMariano2]

@gu3vara 609 wrote:

I’m working on balancing my hormones right now, having low T, hashimoto and low adrenals but I remain quite desperate with my muscle problems, they are stiff, they cramp very often and there is almost always one muscle that twitch somewhere (I’d say light twitches, not apparent to others)…

I also have low ferritin and B12 levels and I’m taking magnesium which doesn’t seem to help.

I noticed a lot more cramping after I switched to Armour, my TSH went up to 12 on one grain and I’m now at 2 grains and symptoms remain. I’m going to get all the thyroid panel done next week to see where I’m at. Should I test total T3 with Ft4 Ft3 and TSH to have a clearer picture maybe?

Should I look somewhere else for those muscle problems? Lyme, Celiac etc…? I have a clean EMG btw, no neuropathy.

Thx for the input

Muscle twitching, restlessness, cramping can occur with low dopamine signaling. These are common side effects, for example, when dopamine receptor blockers are used – such as antipsychotic medications.

Low iron impairs dopamine production.

Low dopamine signaling can also occur from other causes including suboptimal thyroid hormone, excessive norepinephrine signaling, excessive serotonin signaling, suboptimal testosterone, suboptimal cortisol signaling.

—

When wanting to get a clearer picture with thyroid hormone treatment, I would obtain:

• Total T4 – most important value
• Free T3 – second most important value
• Total T3
• Free T4

—

Armour Thyroid with a higher T3 content than what the thyroid gland usually outputs can drop T4 production significantly, resulting in an increase in TSH at low doses since the loss of T4 is not compensated for by the addition of T3 and T4 from Armour Thyroid.

[gu3vara]

I’ll keep working on my iron then. I always assumed it was normal considering it was at the bottom of the normal range, I now understand that a lot of things are suboptimal when they are at the bottom.

I will get a complete thyroid panel this time, including the Total T4 and T3. Last time, my T4 were pretty sad to see at the bottom of the range, so that would explain the high TSH.

Thx to you both for your answers, it’s appreciated

[hardasnails1973]

After looking over a lot of your potential issues you may want to look into possibility of celiac as this is highly interlinked with hashimotos disease. There is a lab that does stool and genetic testing through saliva to rule it completely our. Contact hypothyroidceliac on realthyroidhelp.com. she did not find it until she went to this lab which confirmed it. Now she is 50-60% better by switching over to a gluten free diet. Have you been diagnosed as hypopituitary or has it ever been ruled out medically?

[gu3vara]

I read about the test you are talking about for Celiac, it’s from EnteroLab. I’m interested in it but it’s not covered by my insurance company so I’m hesitating.

I’m not diagnosed with hypopit by my endo. My CFS doctor thinks am I partially hypopit because my ACTH was on the low side with lowish cortisol and my FSH LH were still quite low normal for a Total T of 200. However, my TSH can raise without problem.

[hardasnails1973]

@gu3vara 656 wrote:

I read about the test you are talking about for Celiac, it’s from EnteroLab. I’m interested in it but it’s not covered by my insurance company so I’m hesitating.

I’m not diagnosed with hypopit by my endo. My CFS doctor thinks am I partially hypopit because my ACTH was on the low side with lowish cortisol and my FSH LH were still quite low normal for a Total T of 200. However, my TSH can raise without problem.

CFS in my past experience has been shown to involve adrenal and thyroid imbalance that later go on to effect that sex hormones. Lady with 18 years of CFS mysterious gets better by adding cortef to her current thyroid medicine with in a few weeks time. Makes you wonder if FM and CFS are just thyroid and adrenal malfunction.

[gu3vara]

@hardasnails1973 660 wrote:

CFS in my past experience has been shown to involve adrenal and thyroid imbalance that later go on to effect that sex hormones. Lady with 18 years of CFS mysterious gets better by adding cortef to her current thyroid medicine with in a few weeks time. Makes you wonder if FM and CFS are just thyroid and adrenal malfunction.

I think so too, my hormones are all bad so I think it will get better when I’m in balance again. Some days are though, I can’t even stand up for more than 5 minutes, while some other days I can take walk.

Think i’m still hypothyroid on 2 grains armour, I’ll now soon. I heard low T could cause this huge fatigue and I’m only at week 3 on T shots and still haven’t add HCG. Things will get better, I’m sure of it.

THe other thing that bothers me is that I seem to have some chronic infection that cause me epididimytis. I have abnormal level of white blood cells and red blood cells in my semen analysis. This probably doesn’t help my situation either. Can,t wait to see the urologist in august for that.

[Shaolin]

Gu3vara how did you get all this problems??? hypogonadism/adrenal issues especially

[DrMariano2]

Metabolic-Nutritional problems (such as iron deficiency) have to be addressed before a person can be fully well.

Addressing hormones means working at the signaling level. But if metabolic-nutritional problems are still present, the cells won’t respond to the signals given.

[hardasnails1973]

When raising one particular nutrient there could be a chain reaction with zinc, copper, manganse. How should one raise one nutrient while not creating an issue with another?

Correcting iron deficiency could one use.
50 mgs BID
30 mgs zinc picolate
20 mgs manganse
2 mgs copper.

If a person has copper deficiency then supplementing iron would cause it to build up in the liver resulting in similar issue to hemochromatosis, but probably would be not evident in ferritin levels.

When ever I take copper it makes me turn mean, hard, non loving towards people, social with drawn.

[gu3vara]

@Shaolin 858 wrote:

Gu3vara how did you get all this problems??? hypogonadism/adrenal issues especially

I don’t know what the heck happened to me honnestly…I started having recurrent epididymitis when I was 14 y.o. and my urologist think it damages my testicules too. I had a sperm analysis done recently and I have leukospermia (high white blood cell which is a sign of infection) and extremely low sperm count. So it seems I have primary hypogonadism because of that. It might have went on for years now and I’m 29 now.

I was diagnosed with Hashimoto 3 years ago and I don’t know if there is any relation between those problems.

I went downhill from there, depression, anxiety, muscle problems, insomnia, fatigue, headaches etc… I haven’t recover yet. I’ve been on an effective TRT for a few weeks only (I was on cream for 3 months and I wasn’t absorbing it at all, so I went to shots.

I’m still optimizing thyroid and I’m taking cortef because of a really low adrenal saliva test. I can now tolerate Armour better.

I’m working on improving my B-12 vitamin D iron and essential fats stores that are all depleted.

I had a test done called ION from metametrix done few months ago that was really useful, it’s expensive but it does test more than 300 elements , bacteria, nutriments, amino acids, fats, etc… I wonder if anyone else has experience with this test, it showed that I had pretty good zinc, copper and manganese levels. Hope it’s reliable, my doc uses it for all his CFS cases.

Kind off an horror story really, having that much problems at my age…but I think I have all the puzzle pieces now to improve, it’s just a matter of time. I have a good doctor that helps me now.

[gu3vara]

Btw, could anyone give me input on this symptom, when I get the worst twitching crisis, it also comes with burning tears (not crying, my normal tears become hard to tolerate).

It is relate to potassium imbalance, sodium imbalance?

My aldosterone levels are normal and both sodium / potassium blood levels are mid range.

I had an hair analysis done some time ago that showed extremely high potassium and sodium level

Potassium : 310 (9-40)
Sodium : 330 (12-90)

Any idea about that, i don’t know how to read an hair analysis and not sure if it’s a reliable test. Could it be a missing piece of the puzzle?

Thx,
Seb

[pmgamer18]

I have all the same problems as you and if I remember right so dose Hardasnails. I tested low on Testosterone 27 yrs ago after a bad auto accident where I had hit my head in the roof on the car no seat belt law then.

You can read my story at this link and my update to it.
http://forums.realthyroidhelp.com/viewtopic.php?f=5&t=9239

After 23 yrs on TRT and not doing better I tied HCG doing 500 IU’s 3 x’s / wk. after the 15 shot of HCG we did labs and my Total T doubled so I am not Primary but I am Secondary so we did an MRI on my pituitary nothing showed up. So my Dr. with a Pituitary Dr. he know that is now my Heart Dr. today. When over my old labs and they were screaming a Pituitary problem. So we did more labs my morning fasting cortisol test come in very low 12 so I did a 4x’s in a day salive test each time I was below normal on the range. So to tell if this is my Pituitary we did an ACTH Stim. test and I come in Secondary.

We first treated my low cortisol levels then added in Armour you can read how I did this in this link.
http://forums.realthyroidhelp.com/viewtopic.php?f=5&t=24

Treating all of this I still was not feeling 100% so we tested my Ferritin levels they came back below normal I went on Iron pills doing Cypress Ferrous Fumarate 324 mg, Tablets taking 2 a day with Vit. C and this got me feeling much better but it was upsetting my stomach. I read one needs to take 200 mgs a day of Elemental Iron to get levels up.

Today after all I have been through I now take Feosol Carbonyl Iron tabs 3 a day this cost much more money but is great on my stomach. I have been on Iron pills over 2 yrs now one thing that showed up low on a test just before my heart sugary was Folic Acid it was below normal and I was taking folic acid at the time of the test. Dr. told me it was not converting in my stomach so he told me to take this.

By Thorne Research Folacal now my levels are up but we still don’t know why my Ferritin was below normal on labs. Now after 5 heart sugarys it will take the rest of this yr. for my blood to get back to normal. Then we will see how I do off Iron pills.

My muscle twitching and restlessness are all gone what helped me I feel were getting all my hormones leveled and adding in Vit’s I was low on. Here is a list of them.
=========================================================
PHILIP’S MED’S
• Simvastatin(Zocor) 20 mg. bedtime for Cholestrol.
• Arimidex .25 mg. bed time every 48 hours for control of Estradiol.
• Aspirin 81 mg morning 1x/day.
• Alprazolam(Xanax) .5 mg. up to 1x at bedtime.
• Atenolol 50 mg. 1x/day morning for heart beta-blocker cut in half 25 mgs.
• Isinopril 10 mg. 1x/day morning for BP cut in ¼’s 2.5 mgs.
• Triamterene/HCTZ 37.5/25 mgs. Every 3 days.
• Armour 4 grains 2 morning and one at noon and one at dinner for Thyroid.
• Potassium Chloride 20 mg. 1x/day morning. I stopped this not on a strong water pill anymore.
• Testosterone .35ml. or 70 mgs shot every 3 days.
• HCG 200 IU’s shot the 2 days each in between the Testosterone shot.
• Celebrex 200 mgs. 2x/day morning and dinner.
• Cortef 5 mgs. 10 mgs morning, 5mgs at 9am, 10 mgs at 1pm and 5 mgs at 6pm.

Supplements
• Vit. A 10,000 IU’s 1x/day.
• Vit. E 400 IU’s 1x/day.
• Vit. D 5 drops 10,000 IU’s.
• Folacal Folinic Acid 800 mg. 1x/day
• Feosol Iron 45mgs 3x’s/day morning noon and dinner.
• Glucosamine HCI 1500 MGS. – Chondroitin Sulface 1200 mgs. 2x/day.
• Lovaza 1gm. 1x/day Fish Oil.
• TMG 750mg 1pm and 11pm 2 pills a day.
• Solary Super Bio C 2 x’s/day 1000 mgs. Total.
• l-Arginine and l-Orthinine 100 Capsules, 750 mg, Twinlab 1 at bedtime.
• NOW brand ZMA 800mgs 3 at bedtime.
• Copper 2mgs 1 at noon.
• Dr. Cranton’s PrimeNutrients 1 in the morning.
• Maca. 1 tsp in the moning and 1 tsp at noon.
• Biotics Bio-D-Mulsion Forte Vit. D 2000 IU’s per drop I am doing 5 drops a day.
• I went with NOW brand for the following supplements do to a high levels on a Homocysteine Cardiovascular and below normal level of Folate RBC labs.
• NAC N-Acetyl Cysteine, Selenium, Molybdenum – 600 mg.
• B-12 (Brain) Methylcobalamin – 5000 mcg lozenges.
• Coenzyme B Complex.
• P-5-P (Coenzyme B6) 50 mg.
• I am taking 800 mcg. Folacal for low Folate RBC.

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