Abstract regarding sleep and TSH/T4

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Volume : 33
Issue : 08
Pages : 1115-1118

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SHORT NOTE
Changes in Serum TSH and Free T4 during Human Sleep Restriction
Lynn Kessler, MD1; Arlet Nedeltcheva, MD1; Jacqueline Imperial, BS2; Plamen D. Penev, MD, PhD1

1Department of Medicine and 2General Clinical Resource Center, University of Chicago, Chicago, IL

Study Objectives: To examine whether recurrent sleep restriction is accompanied by changes in measures of thyroid function.
Design: Two-period crossover intervention study.
Setting: University clinical research center and sleep laboratory.
Participants: 11 healthy volunteers (5F/6M) with a mean (± SD) age of 39 ± 5 y and BMI 26.5 ± 1.5 kg/m2.
Intervention: Randomized exposure to 14 days of sedentary living with ad libitum food intake and 5.5- vs. 8.5-h overnight sleep opportunity.
Measurements and Results: Serum thyroid-stimulating hormone (TSH) and free thyroxine (T4) were measured at the end of each intervention. Partial sleep restriction was accompanied by a modest but statistically significant reduction in TSH and free T4, seen mainly in the female participants of the study.
Conclusions: Compared to the well-known rise in TSH and thyroid hormone concentrations during acute sleep loss, tests obtained after 14 days of partial sleep restriction did not show a similar activation of the human thyroid axis.
Keywords: Short sleep duration, sleep deprivation, thyroid hormone, 24-hour profile

Citation: Kessler L; Nedeltcheva A; Imperial J; Penev PD. Changes in serum TSH and free T4 during human sleep restriction. SLEEP 2010;33(8):1115-1118.

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