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Maternal Gluten Sensitivity Raises Risk for Psychosis in Children

Maternal antibodies to dietary antigens and risk for nonaffective psychosis in offspring   Am J Psychiatry. 2012 Jun;169(6):625-32 Authors: Karlsson H, Blomström Å, Wicks S, Yang S, Yolken RH, Dalman C Abstract OBJECTIVE:The authors analyzed archival dried blood spots obtained from newborns to assess whether levels of immunoglobulin G (IgG) directed at dietary antigens were …

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Bereavement Induces Systemic Inflammation

When grief makes you sick: Bereavement induced systemic inflammation is a question of genotype Authors: Schultze-Florey CR, Martínez-Maza O, Magpantay L, Breen EC, Irwin MR, Gündel H, O’Connor MFBrain Behav Immun. 2012 Jun 23; Abstract Although bereavement is associated with increased morbidity and mortality in the surviving spouse, some widow(er)s remain healthy. Genetic variability in expression …

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Type 2 Corticotropin-Releasing Factor Receptor Stimulation Increases Anxiety

Chronic Activation of Corticotropin-Releasing Factor Type 2 Receptors Reveals a Key Role for 5-HT1A Receptor Responsiveness in Mediating Behavioral and Serotonergic Responses to Stressful Challenge.   Biol Psychiatry. 2012 Jun 13; Authors: Neufeld-Cohen A, Kelly PA, Paul ED, Carter RN, Skinner E, Olverman HJ, Vaughan JM, Issler O, Kuperman Y, Lowry CA, Vale WW, Seckl …

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Eye Movement Tests For Schizophrenia

Simple Viewing Tests Can Detect Eye Movement Abnormalities That Distinguish Schizophrenia Cases from Controls with Exceptional Accuracy.   Biol Psychiatry. 2012 May 22; Authors: Benson PJ, Beedie SA, Shephard E, Giegling I, Rujescu D, St Clair D Abstract BACKGROUND: We have investigated which eye-movement tests alone and combined can best discriminate schizophrenia cases from control …

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Sitagliptin (Januvia) has antiinflammatory effects

Sitagliptin Exerts an Antinflammatory Action J Clin Endocrinol Metab. 2012 Jun 28; Authors: Makdissi A, Ghanim H, Vora M, Green K, Abuaysheh S, Chaudhuri A, Dhindsa S, Dandona P Abstract Context:  Sitagliptin is an inhibitor of the enzyme dipeptidyl peptidase-IV (DPP-IV), which degrades the incretins, glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide, and thus, sitagliptin increases …

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Inflammatory Illnesses Decrease Vitamin D 25 OH by Increasing Conversion to Vitamin D 25 Dihydroxy

Circulating interferon-γ correlates with 1,25(OH)D and the 1,25(OH)D-to-25(OH)D ratio Cytokine. 2012 Jun 14; Authors: Barker T, Martins TB, Kjeldsberg CR, Trawick RH, Hill HR Abstract The mechanism responsible for the decrease in vitamin D status (i.e., plasma or serum 25-hydroxyvitamin D (25(OH)D) concentration) during inflammatory stress is unknown in humans. Interferon (IFN)-γ is an inflammatory …

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