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Effect of probiotic bacteria on microbial host defense, growth, and immune function in human immunodeficiency virus type-1 infection. Nutrients. 2011 Dec;3(12):1042-70. Epub 2011 Dec 19. Cunningham-Rundles S, Ahrné S, Johann-Liang R, Abuav R, Dunn-Navarra AM, Grassey C, Bengmark S, Cervia JS. Abstract The hypothesis that probiotic administration protects the gut surface and could delay progression …

Probiotic Bacteria Protect Against Viral Illness Read More »

Would broadening the diagnostic criteria for bipolar disorder do more harm than good? Implications from longitudinal studies of subthreshold conditions. J Clin Psychiatry. 2012 Apr;73(4):437-43 Zimmerman M Abstract BACKGROUND: The Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), is a categorical system that provides descriptive diagnostic criteria for psychiatric syndromes. These syndrome descriptions …

Would lowering the diagnostic criteria for bipolar disorder do more harm than good? Yes Read More »

The renin-angiotensin pathway in posttraumatic stress disorder: angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are associated with fewer traumatic stress symptoms. J Clin Psychiatry. 2012 Jun;73(6):849-55 Khoury NM, Marvar PJ, Gillespie CF, Wingo A, Schwartz A, Bradley B, Kramer M, Ressler KJ Abstract OBJECTIVE: Posttraumatic stress disorder (PTSD) is a debilitating stress-related illness associated with trauma …

The renin-angiotensin pathway in PTSD: ACE inhibitors and ARBs are associated with fewer PTSD symptoms. Read More »

Peripheral benzodiazepine receptor ligands reverse apoptosis resistance of cancer cells in vitro and in vivo Cancer Res. 2002 Mar 1;62(5):1388-93 Decaudin D, Castedo M, Nemati F, Beurdeley-Thomas A, De Pinieux G, Caron A, Pouillart P, Wijdenes J, Rouillard D, Kroemer G, Poupon MF Abstract The mitochondrial peripheral benzodiazepine receptor (mPBR) is involved in a functional …

Benzodiazepines Help Kill Cancer Cells Read More »

Protective role of vitamin C in diazepam-induced apoptosis in rat thymocytes Bratisl Lek Listy. 2012;113(6):350-3 Authors: Pavlovic V, Pavlovic D, Kamenov B, Sarac M, Peric Z, Velojic M Abstract Diazepam, a peripheral-type benzodiazepine receptor ligand, is widely used as a therapeutic agent. On the other hand, peripheral-type benzodiazepines have been shown to induce apoptosis in …

Vitamin C Reduces Benzodiazepine-induced Immunosuppression and Immune Cell Apoptosis Read More »

Quetiapine enhances oligodendrocyte regeneration and myelin repair after cuprizone-induced demyelination Schizophr Res. 2012 Jun;138(1):8-17 Zhang Y, Zhang H, Wang L, Jiang W, Xu H, Xiao L, Bi X, Wang J, Zhu S, Zhang R, He J, Tan Q, Zhang D, Kong J, Li XM Abstract Myelin and oligodendrocyte dysfunctions have been consistently found in patients …

Quetiapine enhances oligodendrocyte regeneration and myelin repair Read More »

Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice. Psychoneuroendocrinology. 2012 Mar 1; Authors: Wohleb ES, Fenn AM, Pacenta AM, Powell ND, Sheridan JF, Godbout JP Abstract Repeated social defeat (RSD) activates neuroendocrine pathways that have a significant influence on immunity and …

Infection in the body increases microglia activation, increases the number of inflammatory CNS macrophages, and promotes social withdrawal Read More »

Neuroplastic changes in depression: A role for the immune system Psychoneuroendocrinology. 2012 Apr 21; Authors: Eyre H, Baune BT Abstract Accumulating evidence suggests that there is a rich cross-talk between the neuroimmune system and neuroplasticity mechanisms under both physiological conditions and pathophysiological conditions in depression. Anti-neuroplastic changes which occur in depression include a decrease in …

Immune System Pro-inflammatory Actions Impair Neuroplasticity During Depression Read More »

Celecoxib and GABA Cooperatively Prevent the Progression of Pancreatic Cancer In Vitro and in Xenograft Models of Stress-Free and Stress-Exposed Mice PLoS One. 2012;7(8):e43376. Epub 2012 Aug 16. Al-Wadei HA, Al-Wadei MH, Ullah MF, Schuller HM. Abstract Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and is associated with high levels of psychological distress. We …

Celebrex (Celecoxib) and GABA Reduce while Social Stresses Increase Progression of Pancreatic Cancer Read More »

Antidepressant combination for major depression in incomplete responders-a systematic review. J Affect Disord. 2012 Jul 24; Authors: Lopes Rocha F, Fuzikawa C, Riera R, Ramos MG, Hara C Abstract BACKGROUND: Antidepressant combination has been suggested as a strategy to increase treatment efficacy. The objective of this study was to perform a systematic review and meta-analysis …

Antidepressant Combination for Major Depression: Flaws in Evidenced-Based Medicine Read More »