Possible Benefit of Dietary Carnosine towards Depressive Disorders. Aging Dis. 2015 Sep;6(5):300 Authors: Hipkiss AR Many stress-related and depressive disorders have been shown to be associated with one or more of the following; shortened telomeres, raised cortisol levels and increased susceptibility to age-related dysfunction. It is suggested here that insufficient availability of the neurological peptide, …
The involvement of BDNF, NGF and GDNF in aging and Alzheimer’s disease Aging Dis. 2015 Sep;6(5):331-41 Authors: Budni J, Bellettini-Santos T, Mina F, Garcez ML, Zugno AI Aging is a normal physiological process accompanied by cognitive decline. This aging process has been the primary risk factor for development of aging-related diseases such as Alzheimer’s …
The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease. Read More »
Low HbA1c and Increased Mortality Risk-is Frailty a Confounding Factor?: Aging Dis. 2015 Aug;6(4):262-70 Authors: Abdelhafiz AH, Sinclair AJ Diabetes mellitus is increasingly becoming an older person disease due to the increased survival and aging of the population. Previous studies which showed benefits of tight glycemic control and a linear relationship between HbA1c and mortality …
Metformin for Weight Loss and Metabolic Control in Overweight Outpatients With Schizophrenia and Schizoaffective Disorder.: “ Related Articles Metformin for Weight Loss and Metabolic Control in Overweight Outpatients With Schizophrenia and Schizoaffective Disorder. Am J Psychiatry. 2013 Jul 12; Authors: Jarskog LF, Hamer RM, Catellier DJ, Stewart DD, Lavange L, Ray N, Golden LH, Lieberman …
Effects of dietary glycemic index on brain regions related to reward and craving in men. Am J Clin Nutr. 2013 Jun 26; Authors: Lennerz BS, Alsop DC, Holsen LM, Stern E, Rojas R, Ebbeling CB, Goldstein JM, Ludwig DS Abstract BACKGROUND: Qualitative aspects of diet influence eating behavior, but the physiologic mechanisms for these calorie-independent …
Why you're hungry after eating Chinese food – It's the rice Read More »
Effect of green tea on glucose control and insulin sensitivity: a meta-analysis of 17 randomized controlled trials. Am J Clin Nutr. 2013 Jun 26; Authors: Liu K, Zhou R, Wang B, Chen K, Shi LY, Zhu JD, Mi MT Abstract BACKGROUND: The results of studies investigating the effect of green tea on glucose control and …
Green tea improves glucose control and insulin sensitivity Read More »
Examining transcranial direct-current stimulation (tDCS) as a treatment for hallucinations in schizophrenia. Am J Psychiatry. 2012 Jul 1;169(7):719-24 Authors: Brunelin J, Mondino M, Gassab L, Haesebaert F, Gaha L, Suaud-Chagny MF, Saoud M, Mechri A, Poulet E Abstract OBJECTIVE: Some 25%–30% of patients with schizophrenia have auditory verbal hallucinations that are refractory to antipsychotic …
Transcranial direct-current stimulation (tDCS) for hallucinations in schizophrenia Read More »
Increased concentrations of inflammatory biomarkers predict antidepressant nonresponse, and inflammatory cytokines can sabotage and circumvent the mechanisms of action of conventional antidepressants. A drug that targets inflammation may assist in the treatment of depression in individuals with high levels of inflammation. Results of a proof-of-concept study by him, Charles Raison, M.D., an associate professor of psychiatry at the University of Arizona, and colleagues showed that a biologic medication was able to reduce depressive symptoms in some subjects who had suffered from major depression for an average of 15 years.
The prevalence of depression is increased in people with diabetes and there are both national and international recommendations for screening of depression in people with diabetes. Most screening is currently sporadic and there are no formal screening programs. Further research is needed to evaluate the most clinically effective and cost effective way of doing so in structured screening programs.
Recently, both the manufacturer of citalopram and the US Food and Drug Administration have warned health care providers and patients about new information implicating drug-induced QTc interval prolongation and torsade de pointes when using citalopram in doses >40 mg/day. This warning is not placed in the context of either benefits or risks in real-world clinical practice, leaving clinicians with an untenable choice between depriving patients of high-dose citalopram or malpractice litigation. We reviewed the literature and found no cases of citalopram-induced sudden cardiac death among patients taking up to 60 mg/day of citalopram and free of risk factors for QTc interval prolongation and torsade de pointes. Because psychotropic drug-induced sudden cardiac death is an outlier in the absence of identified risk factors for QTc interval prolongation and torsade de pointes, we do not believe current Phase 3 and Phase 4 studies provide sufficient information to limit current prescribing practices for citalopram (20 mg to 60 mg/day).