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Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1 Nature Genetics Published online: 17 January 2010 | doi:10.1038/ng.523 Francis J McMahon1, Nirmala Akula1, Thomas G Schulze1,2, Pierandrea Muglia3,4, Federica Tozzi3, Sevilla D Detera-Wadleigh1, C J M Steele1, René Breuer2, Jana Strohmaier2, Jens R Wendland1, Manuel Mattheisen5,6,7, Thomas W Mühleisen5,6, …

The major mood disorders have significant genetic overlap Read More »

Effects of methylprednisolone and glatiramer acetate on nitric oxide formation of cytokine-stimulated cells from the rat oligodendroglial cell line OLN-93. Neuroimmunomodulation. 2010;17(1):23-30 Authors: Holzknecht C, Röhl C OBJECTIVES: In multiple sclerosis, an autoimmune inflammatory disease, oligodendroglia are primarily affected and play an important role in the onset and process of the degeneration of neuronal axons. …

Methylprednisolone reduces nitric oxide formation in cytokine-stimulated oligodendroglial cells Read More »

Kainic acid-activated microglia mediate increased excitability of rat hippocampal neurons in vitro and in vivo: crucial role of interleukin-1beta. Neuroimmunomodulation. 2010;17(1):31-8 Authors: Zheng H, Zhu W, Zhao H, Wang X, Wang W, Li Z OBJECTIVE: It is known that highly activated microglia and the consequent production of inflammatory cytokines were associated with neuroexcitotoxic injuries. The …

Activated microglia increase excitability of rat hippocampal neurons by producing interleukin-1beta. Read More »

Inflammatory biomarkers in patients with posttraumatic stress disorder caused by myocardial infarction and the role of depressive symptoms.: “ Neuroimmunomodulation. 2010;17(1):39-46 Authors: von Känel R, Begré S, Abbas CC, Saner H, Gander ML, Schmid JP OBJECTIVE: Inflammation might link posttraumatic stress disorder (PTSD) with an increased risk of cardiovascular events. We explored the association between …

Inflammatory biomarkers in patients with posttraumatic stress disorder Read More »

Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder. J Psychiatr Res. 2007 Nov;41(9):744-52. Epub 2006 Aug 9. von Känel R, Hepp U, Kraemer B, Traber R, Keel M, Mica L, Schnyder U. Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital/INSELSPITAL, Freiburgstrasse 4, CH-3010 Berne, Switzerland. roland.vonkaenel@insel.ch Posttraumatic stress …

Increased Pro-Inflammatory Activity underlying Posttraumatic Stress Disorder Read More »

Involvement of Nuclear Factor-kappaB and Nurr-1 in Cytokine-Induced Transcription of Proopiomelanocortin Gene in AtT20 Corticotroph Cells. Neuroimmunomodulation. 2009 Nov 17;17(2):88-96 Authors: Takayasu S, Iwasaki Y, Nigawara T, Asai M, Yoshida M, Kageyama K, Suda T Objective: The precise mechanism whereby proinflammatory cytokines activate the hypothalamo-pituitary-adrenal axis is still unclear. We examined whether transcription factors nuclear …

Pro-inflammatory cytokine activation of the hypothalamic-pituitary-adrenal axis via NF-kappaB and Nurr-1 expression Read More »

Effects of Testosterone on Muscle Strength, Physical Function, Body Composition, and Quality of Life in Intermediate-Frail and Frail Elderly Men: A Randomized, Double-Blind, Placebo-Controlled Study. J Clin Endocrinol Metab. 2010 Jan 8; Authors: Srinivas-Shankar U, Roberts SA, Connolly MJ, O’ Connell MD, Adams JE, Oldham JA, Wu FC Context: Physical frailty is associated with reduced …

Testosterone improves Muscle Strength, Physical Function, Body Composition, and Quality of Life in Intermediate-Frail and Frail Elderly Men Read More »

Thiazolidinedione Use and the Longitudinal Risk of Fractures in Patients with Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. 2010 Jan 8; Authors: Habib ZA, Havstad SL, Wells K, Divine G, Pladevall M, Williams LK Context: Thiazolidinedione (TZD) use has recently been associated with an increased risk of fractures. Objective: The aim of this study …

Thiazolidinedione associated with increased Risk of Fractures in Patients with Type 2 Diabetes Mellitus. Read More »

Long-Term Growth Hormone Therapy Changes the Natural History of Body Composition and Motor Function in Children with Prader-Willi Syndrome. J Clin Endocrinol Metab. 2010 Jan 8; Authors: Carrel AL, Myers SE, Whitman BY, Eickhoff J, Allen DB Background: Children with Prader-Willi syndrome (PWS) have decreased muscle mass, hypotonia, and impaired linear growth. Recombinant human GH …

Long-Term Growth Hormone Therapy Improves Body Composition and Motor Function Read More »

Associations of Total Testosterone, Sex Hormone-Binding Globulin, Calculated Free Testosterone, and Luteinizing Hormone with Prevalence of Abdominal Aortic Aneurysm in Older Men. J Clin Endocrinol Metab. 2010 Jan 8; Authors: Yeap BB, Hyde Z, Norman PE, Chubb SA, Golledge J Context: Abdominal aortic aneurysm (AAA) is associated with mortality in older adults, and increasing aortic …

Low Total Testosterone increases risk for Abdominal Aortic Aneurysm Read More »