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Hippocampal Angiogenesis and Progenitor Cell Proliferation Are Increased with Antidepressant Use in Major Depression.   Biol Psychiatry. 2012 May 30; Authors: Boldrini M, Hen R, Underwood MD, Rosoklija GB, Dwork AJ, Mann JJ, Arango V Abstract BACKGROUND: Adult neurogenesis is coupled to angiogenesis in neurogenic niches in the dentate gyrus (DG) and increased by antidepressants in rodents. …

Antidepressants are still useful – they increase neurogenesis and angiogenesis Read More »

Estrogen levels are associated with extinction deficits in women with posttraumatic stress disorder. Biol Psychiatry. 2012 Jul 1;72(1):19-24. Epub 2012 Apr 12. Glover EM, Jovanovic T, Mercer KB, Kerley K, Bradley B, Ressler KJ, Norrholm SD. Abstract BACKGROUND:Women are twice as likely to develop posttraumatic stress disorder (PTSD) than men. As shown in our previous work, …

Low Estrogen Predisposes Women to Posttraumatic Stress Disorder. Read More »

Telomeres and Early-Life Stress: An Overview Biol Psychiatry. 2012 Jul 23;  Authors: Price LH, Kao HT, Burgers DE, Carpenter LL, Tyrka AR Abstract The long-term sequelae of adverse early-life experiences have long been a focus in psychiatry, with a historic neurobiological emphasis on physiological systems that are demonstrably stress-responsive, such as the hypothalamic-pituitary-adrenal axis and …

Shorter Telomeres in Severe Mental Illness Read More »

Thyroid Hormone Enhances Nitric Oxide-Mediated Bacterial Clearance and Promotes Survival after Meningococcal Infection PLoS One. 2012;7(7):e41445. Epub 2012 Jul 23. Chen Y, Sjölinder M, Wang X, Altenbacher G, Hagner M, Berglund P, Gao Y, Lu T, Jonsson AB, Sjölinder H. Abstract Euthyroid sick syndrome characterized by reduced levels of thyroid hormones (THs) is observed in …

Thyroid Hormone Enhances Nitric Oxide-Mediated Bacterial Clearance and Promotes Survival after Meningococcal Infection Read More »

Mirtazapine Inhibits Tumor Growth via Immune Response and Serotonergic System PLoS One. 2012;7(7):e38886. Epub 2012 Jul 13.Fang CK, Chen HW, Chiang IT, Chen CC, Liao JF, Su TP, Tung CY, Uchitomi Y, Hwang JJ. Abstract To study the tumor inhibition effect of mirtazapine, a drug for patients with depression, CT26/luc colon carcinoma-bearing animal model was …

Mirtazapine Inhibits Tumor Growth via Immune Response and Serotonergic System Read More »

Dose-Dependent Effects of Endotoxin on Neurobehavioral Functions in Humans PLoS One. 2011;6(12):e28330. Epub 2011 Dec 2. Grigoleit JS, Kullmann JS, Wolf OT, Hammes F, Wegner A, Jablonowski S, Engler H, Gizewski E, Oberbeck R, Schedlowski M. Abstract Clinical and experimental evidence document that inflammation and increased peripheral cytokine levels are associated with depression-like symptoms and …

Dose-Dependent Effects of Endotoxin on Neurobehavioral Functions in Humans Read More »

Vitamin D3 supplementation (4000 IU/d for 1 y) eliminates differences in circulating 25-hydroxyvitamin D between African American and white men.   Am J Clin Nutr. 2012 Aug;96(2):332-6 Authors: Garrett-Mayer E, Wagner CL, Hollis BW, Kindy MS, Gattoni-Celli S Abstract BACKGROUND: African Americans suffer disproportionately from diabetes and cardiovascular disease and are significantly more likely to …

African-Americans Need 4000 IU a day of Vitamin D3 to Eliminate Vitamin D 25 OH Disparity with Caucasians. Read More »

Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study.   Am J Clin Nutr. 2010 Feb;91(2):337-42 Authors: Shen J, Lai CQ, Mattei J, Ordovas JM, Tucker KL BACKGROUND: Low vitamin B-6 status has been linked to an increased risk of cardiovascular diseases. The cardioprotective effects …

Vitamin B6 (pyridoxal-5'-phosphate) Lowers Risk for Heart Disease, Obesity, and Diabetes Read More »

Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk Study? Yamagishi K, Iso H, Yatsuya H, Tanabe N, Date C, Kikuchi S, Yamamoto A, Inaba Y, Tamakoshi A; for the JACC Study Group. Am J Clin Nutr. 2010 Aug 4.   …

Saturated Fat Reduces Risk for Stroke Read More »

   Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Chen SK, Tvrdik P, Peden E, Cho S, Wu S, Spangrude G, Capecchi MR. Cell. 2010 May 28;141(5):775-85.   Mouse Hoxb8 mutants show unexpected behavior manifested by compulsive grooming and hair removal, similar to behavior in humans with the obsessive-compulsive disorder spectrum disorder trichotillomania.   As Hox gene disruption often …

Microglial Mutation contributes to obsessive-compulsive behavior Read More »