Peripheral benzodiazepine receptor ligands reverse apoptosis resistance of cancer cells in vitro and in vivo Cancer Res. 2002 Mar 1;62(5):1388-93 Decaudin D, Castedo M, Nemati F, Beurdeley-Thomas A, De Pinieux G, Caron A, Pouillart P, Wijdenes J, Rouillard D, Kroemer G, Poupon MF Abstract The mitochondrial peripheral benzodiazepine receptor (mPBR) is involved in a functional …
Protective role of vitamin C in diazepam-induced apoptosis in rat thymocytes Bratisl Lek Listy. 2012;113(6):350-3 Authors: Pavlovic V, Pavlovic D, Kamenov B, Sarac M, Peric Z, Velojic M Abstract Diazepam, a peripheral-type benzodiazepine receptor ligand, is widely used as a therapeutic agent. On the other hand, peripheral-type benzodiazepines have been shown to induce apoptosis in …
Vitamin C Reduces Benzodiazepine-induced Immunosuppression and Immune Cell Apoptosis Read More »
Quetiapine enhances oligodendrocyte regeneration and myelin repair after cuprizone-induced demyelination Schizophr Res. 2012 Jun;138(1):8-17 Zhang Y, Zhang H, Wang L, Jiang W, Xu H, Xiao L, Bi X, Wang J, Zhu S, Zhang R, He J, Tan Q, Zhang D, Kong J, Li XM Abstract Myelin and oligodendrocyte dysfunctions have been consistently found in patients …
Quetiapine enhances oligodendrocyte regeneration and myelin repair Read More »
Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice. Psychoneuroendocrinology. 2012 Mar 1; Authors: Wohleb ES, Fenn AM, Pacenta AM, Powell ND, Sheridan JF, Godbout JP Abstract Repeated social defeat (RSD) activates neuroendocrine pathways that have a significant influence on immunity and …
Neuroplastic changes in depression: A role for the immune system Psychoneuroendocrinology. 2012 Apr 21; Authors: Eyre H, Baune BT Abstract Accumulating evidence suggests that there is a rich cross-talk between the neuroimmune system and neuroplasticity mechanisms under both physiological conditions and pathophysiological conditions in depression. Anti-neuroplastic changes which occur in depression include a decrease in …
Immune System Pro-inflammatory Actions Impair Neuroplasticity During Depression Read More »
Celecoxib and GABA Cooperatively Prevent the Progression of Pancreatic Cancer In Vitro and in Xenograft Models of Stress-Free and Stress-Exposed Mice PLoS One. 2012;7(8):e43376. Epub 2012 Aug 16. Al-Wadei HA, Al-Wadei MH, Ullah MF, Schuller HM. Abstract Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and is associated with high levels of psychological distress. We …
Antidepressant combination for major depression in incomplete responders-a systematic review. J Affect Disord. 2012 Jul 24; Authors: Lopes Rocha F, Fuzikawa C, Riera R, Ramos MG, Hara C Abstract BACKGROUND: Antidepressant combination has been suggested as a strategy to increase treatment efficacy. The objective of this study was to perform a systematic review and meta-analysis …
Antidepressant Combination for Major Depression: Flaws in Evidenced-Based Medicine Read More »
Risk of future depression in people who are obese but metabolically healthy: the English longitudinal study of ageing Molecular Psychiatry 17, 940 (September 2012). doi:10.1038/mp.2012.30 M Hamer, G D Batty & M Kivimaki Abstract There is some evidence to suggest that obesity is a risk factor for the development of depression, although this is not …
Obesity Increases the Risk for Depression Particularly if Not Metabolically Healthy Read More »
Mood-state effects on amygdala volume in bipolar disorder J Affect Disord. 2012 Aug;139(3):298-301 Authors: Foland-Ross LC, Brooks JO, Mintz J, Bartzokis G, Townsend J, Thompson PM, Altshuler LL Abstract BACKGROUND: Prior structural neuroimaging studies of the amygdala in patients with bipolar disorder have reported higher or lower volumes, or no difference relative to healthy controls. …
Amygdala is smaller in bipolar disorder depressed patients Read More »
Astrocytes are seen signaling through gap junctions using calcium waves in this video from garlandscien.