Losartan, a therapeutic candidate in congenital muscular dystrophy: studies in the dy(2J) /dy(2J) mouse Ann Neurol. 2012 May;71(5):699-708 Elbaz M, Yanay N, Aga-Mizrachi S, Brunschwig Z, Kassis I, Ettinger K, Barak V, Nevo Y Abstract OBJECTIVE: Lamininα2-deficient congenital muscular dystrophy type 1A (MDC1A) is a cureless disease associated with severe disability and shortened lifespan. Previous …

Losartan Reduces Fibrosis and Improves Muscle Strength in Muscular Dystrophy Model Read More »

Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis Ann Neurol. 2012 Aug;72(2):234-40 Mowry EM, Waubant E, McCulloch CE, Okuda DT, Evangelista AA, Lincoln RR, Gourraud PA, Brenneman D, Owen MC, Qualley P, Bucci M, Hauser SL, Pelletier D Abstract OBJECTIVE: We sought to determine whether vitamin D status is associated …

Vitamin D Reduces Multiple Sclerosis Lesions Read More »

The role of inflammatory cytokines in cognition and other non-motor symptoms of Parkinson’s disease. Psychosomatics. 2010 Nov-Dec;51(6):474-9. Menza M, Dobkin RD, Marin H, Mark MH, Gara M, Bienfait K, Dicke A, Kusnekov A. Abstract BACKGROUND:Parkinson’s disease (PD) affects patients’ lives with more than just physical impairment. Many of the non-motor aspects of PD, such as …

Inflammatory Cytokine Cause Cognitive Impairment, Depression, And Sleep Disturbance And Other Non-Motor Symptoms Of Parkinsons Disease Read More »

Sildenafil reduces insulin-resistance in human endothelial cells PLoS One. 2011 Jan 28;6(1):e14542.Mammi C, Pastore D, Lombardo MF, Ferrelli F, Caprio M, Consoli C, Tesauro M, Gatta L, Fini M, Federici M, Sbraccia P, Donadel G, Bellia A, Rosano GM, Fabbri A, Lauro D. Abstract BACKGROUND:The efficacy of Phosphodiesterase 5 (PDE5) inhibitors to re-establish endothelial function …

Viagra Reduces Insulin Resistance in Endothelial Cells Read More »

Yogic meditation reverses NF-κB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial Psychoneuroendocrinology. 2012 Jul 13; Black DS, Cole SW, Irwin MR, Breen E, St Cyr NM, Nazarian N, Khalsa DS, Lavretsky H Abstract BACKGROUND: Although yoga and meditation have been used for stress reduction with reported improvement …

Yogic Meditation Reduces Inflammation By Reducing NF-κB and Increasing IRF -related Gene Transcription of Pro-inflammatory Cytokines Read More »

Brief Wakeful Resting Boosts New Memories Over the Long Term Psychol Sci. 2012 Jul 24; Dewar M, Alber J, Butler C, Cowan N, Della Sala S Abstract A brief wakeful rest after new verbal learning enhances memory for several minutes. In the research reported here, we explored the possibility of extending this rest-induced memory enhancement …

Brief Wakeful Resting Boosts Memory Consolidation and Retention Read More »

The antitumour effect of {gamma}{delta} T-cells is enhanced by valproic acid-induced up-regulation of NKG2D ligands Anticancer Res. 2010 Nov;30(11):4509-13 Suzuki T, Terao S, Acharya B, Naoe M, Yamamoto S, Okamura H, Gotoh A Abstract BACKGROUND: The aim of this study wsa to evaluate the additive effect of valproic acid (VPA) to γδ T-cell cytotoxicity against …

Valproic Acid helps T-Cells Kill Cancer Cells Read More »

Effect of probiotic bacteria on microbial host defense, growth, and immune function in human immunodeficiency virus type-1 infection. Nutrients. 2011 Dec;3(12):1042-70. Epub 2011 Dec 19. Cunningham-Rundles S, Ahrné S, Johann-Liang R, Abuav R, Dunn-Navarra AM, Grassey C, Bengmark S, Cervia JS. Abstract The hypothesis that probiotic administration protects the gut surface and could delay progression …

Probiotic Bacteria Protect Against Viral Illness Read More »

Would broadening the diagnostic criteria for bipolar disorder do more harm than good? Implications from longitudinal studies of subthreshold conditions. J Clin Psychiatry. 2012 Apr;73(4):437-43 Zimmerman M Abstract BACKGROUND: The Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), is a categorical system that provides descriptive diagnostic criteria for psychiatric syndromes. These syndrome descriptions …

Would lowering the diagnostic criteria for bipolar disorder do more harm than good? Yes Read More »

The renin-angiotensin pathway in posttraumatic stress disorder: angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are associated with fewer traumatic stress symptoms. J Clin Psychiatry. 2012 Jun;73(6):849-55 Khoury NM, Marvar PJ, Gillespie CF, Wingo A, Schwartz A, Bradley B, Kramer M, Ressler KJ Abstract OBJECTIVE: Posttraumatic stress disorder (PTSD) is a debilitating stress-related illness associated with trauma …

The renin-angiotensin pathway in PTSD: ACE inhibitors and ARBs are associated with fewer PTSD symptoms. Read More »