Mental fatigue caused by prolonged cognitive load associated with sympathetic hyperactivity Behav Brain Funct. 2011;7:17 Mizuno K, Tanaka M, Yamaguti K, Kajimoto O, Kuratsune H, Watanabe Y Abstract BACKGROUND: It is known that chronic fatigue is associated with sympathetic hyperactivity. However, the relationship between autonomic function and mental fatigue caused by a prolonged mental load …

Mental Fatigue Associated with Sympathetic Hyperactivity Read More »

The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men J Clin Endocrinol Metab. 2004 Jul;89(7):3313-8 Malkin CJ, Pugh PJ, Jones RD, Kapoor D, Channer KS, Jones TH. Abstract Testosterone has immune-modulating properties, and current in vitro evidence suggests that testosterone may suppress the expression of the proinflammatory cytokines TNF-alpha, …

Testosterone is anti-inflammatory Read More »

Stress, food, and inflammation: psychoneuroimmunology and nutrition at the cutting edge    Psychosom Med. 2010 May;72(4):365-9 Kiecolt-Glaser JK Abstract Inflammation is the common link among the leading causes of death. Mechanistic studies have shown how various dietary components can modulate key pathways to inflammation, including sympathetic activity, oxidative stress, transcription factor nuclear factor-kappaB activation, and …

Stress, food, and inflammation Read More »

Schizophrenia genes, epigenetics and psychoneuroimmunology therapeutics: all make sense now? J Psychopharmacol. 2011 Jun;25(6):713-4 Müller N, Dursun SM Abstract Genetics, epigenetics, infection as an environmental factor, functional findings for the immune system, and a therapeutic approach with anti-inflammatory therapy provide evidence for a pivotal role of the immune system in schizophrenia. This field, therefore, should …

Schizophrenia and anti-inflammatory therapy Read More »

Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage Ann Neurol. 2012 Jul;72(1):82-90 Librizzi L, Noè F, Vezzani A, de Curtis M, Ravizza T Abstract OBJECTIVE: Epilepsy is a common neurological disorder characterized by recurrent seizures often unresponsive to pharmacological treatment. Brain inflammation is considered a crucial etiopathogenetic mechanism of epilepsy that could be …

Seizures cause inflammation which sustains seizure recurrence and causes blood-brain barrier damage. Read More »

Psychoneuroimmunologic factors in inflammatory bowel disease Inflamm Bowel Dis. 2011 Mar;17(3):849-57 Authors: Mackner LM, Clough-Paabo E, Pajer K, Lourie A, Crandall WV Abstract BACKGROUND: Bidirectional relationships between the immune system, nervous system, and psychological processes likely exist in inflammatory bowel disease (IBD) because stress can affect IBD, and IBD is associated with an increased risk …

Psychoneuroimmunologic Factors In Inflammatory Bowel Disease Read More »

Dietary intakes of berries and flavonoids in relation to cognitive decline Ann Neurol. 2012 Jul;72(1):135-43 Authors: Devore EE, Kang JH, Breteler MM, Grodstein F Abstract OBJECTIVE: Berries are high in flavonoids, especially anthocyanidins, and improve cognition in experimental studies. We prospectively evaluated whether greater long-term intakes of berries and flavonoids are associated with slower rates …

Berries and flavonoids reduce cognitive decline. Read More »

Older men who use computers have lower risk of dementia. PLoS One. 2012;7(8):e44239. Epub 2012 Aug 28. Almeida OP, Yeap BB, Alfonso H, Hankey GJ, Flicker L, Norman PE. OBJECTIVE:To determine if older men who use computers have lower risk of developing dementia. METHODS:Cohort study of 5506 community-dwelling men aged 69 to 87 years followed …

Older Men Who Use Computers Have Lower Risk of Dementia Read More »

A comparison of psychiatry and internal medicine: a bibliometric study Acad Psychiatry. 2012 Mar 1;36(2):129-32 Stone K, Whitham EA, Ghaemi SN Abstract OBJECTIVE: Psychiatric education needs to expose students to a broad range of topics. One resource for psychiatric education, both during initial training and in later continuing medical education, is the scientific literature, as …

A comparison of psychiatry and internal medicine Read More »

Reduced GABA Concentration in Attention-Deficit/Hyperactivity DisorderReduced GABA Concentration in ADHD Arch Gen Psychiatry. 2012 Jul 1;69(7):750-3 Authors: Edden RA, Crocetti D, Zhu H, Gilbert DL, Mostofsky SH Abstract CONTEXT Attention-deficit/hyperactivity disorder (ADHD) is a developmental disorder characterized by a deficit in behavioral inhibition. Recent evidence also suggests a deficit in cortical inhibition via the GABA …

Reduced GABA Concentration in Attention-Deficit/Hyperactivity DisorderReduced GABA Concentration in ADHD. Read More »