Neurobiological trait abnormalities in bipolar disorder. Related Articles Neurobiological trait abnormalities in bipolar disorder. Mol Psychiatry. 2009 Sep;14(9):833-46 Authors: Langan C, McDonald C Dissecting trait neurobiological abnormalities in bipolar disorder (BD) from those characterizing episodes of mood disturbance will help elucidate the aetiopathogenesis of the illness. This selective review highlights the immunological, neuroendocrinological, molecular biological …

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Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients. Related Articles Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients. Mol Psychiatry. 2009 Dec 29; Authors: Kim HW, Rapoport SI, Rao JS Mood stabilizers that are approved for treating bipolar disorder (BD), when given chronically to rats, decrease expression …

Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients. Read More »

Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain. Related Articles Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain. Mol Psychiatry. 2009 Dec;14(12):1068-9 Authors: Marchalant Y, Brothers HM, Wenk GL PMID: 19920834 [PubMed – in process]

New neuron production can be increased in the hippocampus of aged rats following cannabinoid treatment. Related Articles New neuron production can be increased in the hippocampus of aged rats following cannabinoid treatment. Mol Psychiatry. 2009 Dec;14(12):1067, 1068-9 Authors: Marchalant Y, Brothers HM, Wenk GL PMID: 19920833 [PubMed – in process] ———– Wouldn’t this be an …

New neuron production can be increased in the hippocampus of aged rats following cannabinoid treatment. Read More »

Ovarian Steroids Decrease DNA Fragmentation in the Serotonin Neurons of Non-Injured Rhesus Macaques. Related Articles Ovarian Steroids Decrease DNA Fragmentation in the Serotonin Neurons of Non-Injured Rhesus Macaques. Mol Psychiatry. 2009 Oct 13; Authors: Lima FB, Bethea CL We previously found that ovarian steroids promote neuroprotection in serotonin neurons by decreasing the expression of pro-apoptotic …

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Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation. Related Articles Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation. Mol Psychiatry. 2009 Sep 22; Authors: Rummel C, Inoue W, Poole S, Luheshi GN The appetite suppressing hormone leptin has emerged as an important modulator of immune function and is now …

Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation. Read More »

The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation. Related Articles The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation. Mol Psychiatry. 2009 Aug 25; Authors: McEwen BS, Chattarji S, Diamond DM, Jay TM, Reagan LP, Svenningsson P, Fuchs E Tianeptine is a clinically used antidepressant that has drawn …

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Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis. Related Articles Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis. Mol Psychiatry. 2010 Jan;15(1):80-92 Authors: Taliaz D, Stall N, Dar DE, Zangen A Depression has been associated with reduced …

Knockdown of brain-derived neurotrophic factor precipitates behaviors associated with depression and reduces neurogenesis. Read More »

Detrimental effects of glucocorticoids on neuronal migration during brain development. Related Articles Detrimental effects of glucocorticoids on neuronal migration during brain development. Mol Psychiatry. 2009 Dec;14(12):1119-31 Authors: Fukumoto K, Morita T, Mayanagi T, Tanokashira D, Yoshida T, Sakai A, Sobue K Glucocorticoids, the most downstream effectors of the hypothalamus-pituitary-adrenal axis, are one of main mediators …

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Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. Related Articles Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. Mol Psychiatry. 2009 Jun 2; Authors: Rao JS, Harry GJ, Rapoport SI, Kim HW Reports of cognitive decline, symptom worsening and brain atrophy in bipolar disorder (BD) …

Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. Read More »