Plasma concentrations of retinol in obese children and adolescents: relationship to metabolic syndrome components Rev Paul Pediatr. 2014 Mar;32(1):50-4 Authors: Teske M, Melges AP, de Souza FI, Fonseca FL, Sarni RO OBJECTIVE: To evaluate obese children and adolescents’ retinol plasma levels and to correlate them with metabolic syndrome components. METHODS: Cross-sectional study with 61 obese …

Vitamin A Deficiency Leads to Diabetes and Obesity Read More »

Molecular Mechanisms and Timing of Cortical Immune Activation in Schizophrenia Am J Psychiatry. 2015 Jul 2;:appiajp201515010019 Authors: Volk DW, Chitrapu A, Edelson JR, Roman KM, Moroco AE, Lewis DA OBJECTIVE:  Immune-related abnormalities are commonly reported in schizophrenia, including higher mRNA levels for the viral restriction factor interferon-induced transmembrane protein (IFITM) in the prefrontal cortex. The …

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Effect of tDCS on auditory hallucinations in schizophrenia: Influence of catechol-O-methyltransferase (COMT) Val158Met polymorphism Asian J Psychiatr. 2015 Jun 2; Authors: Shivakumar V, Chhabra H, Subbanna M, Agarwal SM, Bose A, Kalmady SV, Narayanaswamy JC, Debnath M, Venkatasubramanian G   Dysregulated cortical plasticity has been demonstrated to underlie the pathogenesis of positive symptoms like auditory …

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Retinoid X receptor: the forgotten partner in regulating lipid metabolism? Am J Clin Nutr. 2015 Jun 10;  Authors: Neuschwander-Tetri BA People with non-alcoholic fatty liver disease have lower circulating RA concentrations than do normal controls.  The differences were not trivial, with concentrations in those having severe NASH being less than half the concentrations in controls.  Hepatic expression …

Vitamin A Regulates Lipid Metabolism Read More »

The adipocyte as an endocrine organ in the regulation of metabolic homeostasis Neuropharmacology. 2012 Jul;63(1):57-75 Authors: Harwood HJ Abstract Over the past decade and a half it has become increasingly clear that adipose tissue is a much more complex organ than was initially considered and that its metabolic functions extend well beyond the classical actions …

Fat as an endocrine organ regulating metabolism Read More »

Activation of immune responses to brain antigens after stroke.   Activation of immune responses to brain antigens after stroke. J Neurochem. 2012 Nov;123 Suppl 2:148-55 Authors: Becker KJ Abstract Infection is common after stroke and is independently associated with a worse outcome. The predisposition to infection following stroke is in part related to a sympathetically …

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A Trial of Prazosin for Combat Trauma PTSD With Nightmares in Active-Duty Soldiers Returned From Iraq and Afghanistan Am J Psychiatry. 2013 Jul 12; Authors: Raskind MA, Peterson K, Williams T, Hoff DJ, Hart K, Holmes H, Homas D, Hill J, Daniels C, Calohan J, Millard SP, Rohde K, O’Connell J, Pritzl D, Feiszli K, …

Prazosin for Combat Trauma PTSD in Active-Duty Soldiers Returned From Iraq and Afghanistan. Read More »

Possible Benefit of Dietary Carnosine towards Depressive Disorders. Aging Dis. 2015 Sep;6(5):300 Authors: Hipkiss AR Many stress-related and depressive disorders have been shown to be associated with one or more of the following; shortened telomeres, raised cortisol levels and increased susceptibility to age-related dysfunction. It is suggested here that insufficient availability of the neurological peptide, …

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The involvement of BDNF, NGF and GDNF in aging and Alzheimer’s disease Aging Dis. 2015 Sep;6(5):331-41  Authors: Budni J, Bellettini-Santos T, Mina F, Garcez ML, Zugno AI   Aging is a normal physiological process accompanied by cognitive decline. This aging process has been the primary risk factor for development of aging-related diseases such as Alzheimer’s …

The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease. Read More »

Low HbA1c and Increased Mortality Risk-is Frailty a Confounding Factor?:  Aging Dis. 2015 Aug;6(4):262-70 Authors: Abdelhafiz AH, Sinclair AJ Diabetes mellitus is increasingly becoming an older person disease due to the increased survival and aging of the population. Previous studies which showed benefits of tight glycemic control and a linear relationship between HbA1c and mortality …

Low HbA1c and Increased Mortality Risk Read More »