Low-dose Transdermal Testosterone Augmentation Therapy Improves Depression Severity in Women Karen K. Miller, MD, Roy H. Perlis, MD, MSc, George I. Papakostas, MD, David Mischoulon, MD, PhD, Dan V. Iosifescu, MD, MSc, Danielle J. Brick, BA, and Maurizio Fava, MD CNS Spectr. 2009;14(12):688-694 [download PDF] Background: Inadequate response to antidepressant monotherapy in women with major …

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Urate as a predictor of the rate of clinical decline in Parkinson disease. Urate as a predictor of the rate of clinical decline in Parkinson disease. Arch Neurol. 2009 Dec;66(12):1460-8 Authors: Ascherio A, LeWitt PA, Xu K, Eberly S, Watts A, Matson WR, Marras C, Kieburtz K, Rudolph A, Bogdanov MB, Schwid SR, Tennis M, …

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Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans. Related Articles Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans. Neurobiol Dis. 2009 Dec 23; Molteni R, Cattaneo A, Calabrese F, Macchi F, …

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Chronic psychosocial stress triggers cognitive impairment in a novel at-risk model of Alzheimer’s disease Neurobiology of Disease, In Press, Accepted Manuscript, Available online 4 January 2010Trinh T., Tran , Marisa, Srivareerat , Karim A., Alkadhi Abstract Although it is generally accepted that Aβ contributes to the pathogenesis of Alzheimer’s disease (AD), other factors that impact …

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Reductions of acetylcholine release and nerve growth factor expression are correlated with memory impairment induced by interleukin-1beta administrations: effects of omega-3 fatty acid EPA treatment. Related Articles Reductions of acetylcholine release and nerve growth factor expression are correlated with memory impairment induced by interleukin-1beta administrations: effects of omega-3 fatty acid EPA treatment. J Neurochem. 2009 …

Interleukin-1beta impairs memory by reducing acetylcholine release and nerve growth factor expression, reversed by Omega-3 Fatty Acid EPA treatment Read More »

Inhibiting p53 pathways in microglia attenuates microglial-evoked neurotoxicity following exposure to Alzheimer peptides.: “ Related Articles Inhibiting p53 pathways in microglia attenuates microglial-evoked neurotoxicity following exposure to Alzheimer peptides. J Neurochem. 2009 Nov 6; Authors: Davenport CM, Sevastou IG, Hooper C, Pocock JM Microglial activation can lead to microglial apoptosis, which may serve to remove …

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Is Heart Failure a mental illness? At the very least, it is a psychosomatic illness as this press release indicates. ———- Public release date: 6-Jan-2010 Contact: David March dmarch1@jhmi.edu 410-955-1534 Johns Hopkins Medical Institutions Old antidepressant offers promise in treating heart failure Monoamine oxidase-A inhibitor drug blocks buildup of toxic free radicals in animal hearts …

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Systemic lipopolysaccharide (LPS)-induced microglial activation results in different temporal reduction of CD200 and CD200 receptor gene expression in the brain. Related Articles Systemic lipopolysaccharide (LPS)-induced microglial activation results in different temporal reduction of CD200 and CD200 receptor gene expression in the brain. J Neuroimmunol. 2009 Sep 29;214(1-2):78-82 Authors: Masocha W LPS activates microglia, which are …

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Comparative Effectiveness of 5 Smoking Cessation Pharmacotherapies in Primary Care Clinics [Original Investigation] Stevens S. Smith, PhD; Danielle E. McCarthy, PhD; Sandra J. Japuntich, PhD; Bruce Christiansen, PhD; Megan E. Piper, PhD; Douglas E. Jorenby, PhD; David L. Fraser, MS; Michael C. Fiore, MD, MPH; Timothy B. Baker, PhD; Thomas C. Jackson, MD Arch Intern …

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Physical Activity and Male Colorectal Cancer Survival [Original Investigation] Jeffrey A. Meyerhardt, MD, MPH; Edward L. Giovannucci, MD, ScD; Shuji Ogino, MD, PhD; Gregory J. Kirkner; Andrew T. Chan, MD, MPH; Walter Willett, MD, DrPH; Charles S. Fuchs, MD, MPH Arch Intern Med. 2009;169(22):2102-2108. Background Although physically active individuals have a lower risk of developing …

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