Thyroid Hormone Enhances Nitric Oxide-Mediated Bacterial Clearance and Promotes Survival after Meningococcal Infection

Thyroid Hormone Enhances Nitric Oxide-Mediated Bacterial Clearance and Promotes Survival after Meningococcal Infection PLoS One. 2012;7(7):e41445. Epub 2012 Jul 23. Chen Y, Sjölinder M, Wang X, Altenbacher G, Hagner M, Berglund P, Gao Y, Lu T, Jonsson AB, Sjölinder H. Abstract Euthyroid sick syndrome characterized by reduced levels of thyroid hormones (THs) is observed in …

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Mirtazapine Inhibits Tumor Growth via Immune Response and Serotonergic System

Mirtazapine Inhibits Tumor Growth via Immune Response and Serotonergic System PLoS One. 2012;7(7):e38886. Epub 2012 Jul 13.Fang CK, Chen HW, Chiang IT, Chen CC, Liao JF, Su TP, Tung CY, Uchitomi Y, Hwang JJ. Abstract To study the tumor inhibition effect of mirtazapine, a drug for patients with depression, CT26/luc colon carcinoma-bearing animal model was …

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Dose-Dependent Effects of Endotoxin on Neurobehavioral Functions in Humans

Dose-Dependent Effects of Endotoxin on Neurobehavioral Functions in Humans PLoS One. 2011;6(12):e28330. Epub 2011 Dec 2. Grigoleit JS, Kullmann JS, Wolf OT, Hammes F, Wegner A, Jablonowski S, Engler H, Gizewski E, Oberbeck R, Schedlowski M. Abstract Clinical and experimental evidence document that inflammation and increased peripheral cytokine levels are associated with depression-like symptoms and …

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African-Americans Need 4000 IU a day of Vitamin D3 to Eliminate Vitamin D 25 OH Disparity with Caucasians.

Vitamin D3 supplementation (4000 IU/d for 1 y) eliminates differences in circulating 25-hydroxyvitamin D between African American and white men.   Am J Clin Nutr. 2012 Aug;96(2):332-6 Authors: Garrett-Mayer E, Wagner CL, Hollis BW, Kindy MS, Gattoni-Celli S Abstract BACKGROUND: African Americans suffer disproportionately from diabetes and cardiovascular disease and are significantly more likely to …

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Vitamin B6 (pyridoxal-5'-phosphate) Lowers Risk for Heart Disease, Obesity, and Diabetes

Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study.   Am J Clin Nutr. 2010 Feb;91(2):337-42 Authors: Shen J, Lai CQ, Mattei J, Ordovas JM, Tucker KL BACKGROUND: Low vitamin B-6 status has been linked to an increased risk of cardiovascular diseases. The cardioprotective effects …

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Microglial Mutation contributes to obsessive-compulsive behavior

   Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Chen SK, Tvrdik P, Peden E, Cho S, Wu S, Spangrude G, Capecchi MR. Cell. 2010 May 28;141(5):775-85.   Mouse Hoxb8 mutants show unexpected behavior manifested by compulsive grooming and hair removal, similar to behavior in humans with the obsessive-compulsive disorder spectrum disorder trichotillomania.   As Hox gene disruption often …

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The Usefulness of TSH

Effect of Exogenous Thyroid Hormone Intake on the Interpretation of Serum TSH Test Results: http://www.thyroidscience.com/ hypotheses/ warmingham.2010 /warmingham.intro.7.2010.htm Here is the free PDF: http://www.thyroidscience.com/ hypotheses/ warmingham.2010/ warmingham.7.18.10.pdf I prefer monitoring actual thyroid hormone levels in addition to TSH (Thyroid Stimulating Hormone) for assessment and treatment, rather than relying on TSH alone. One major factor is that there …

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Reducing dietary sodium: the case for caution.

Reducing dietary sodium: the case for caution. JAMA. 2010 Feb 3;303(5):448-9 Authors: Alderman MH QUOTE: Multiple randomized clinical trials (RCTs) have established that reduction of sodium intake sufficient to lower blood pressure also increases sympathetic nerve activity, decreases insulin sensitivity, activates the renin angiotensin system, and stimulates aldosterone secretion. ———- Low salt diets lead to: …

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