Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease Cytokine. 2012 Aug;59(2):442-9 Authors: Coulon S, Francque S, Colle I, Verrijken A, Blomme B, Heindryckx F, De Munter S, Prawitt J, Caron S, Staels B, Van Vlierberghe H, Van Gaal L, Geerts A Abstract The liver is a major target of injury …
Non-alcoholic fatty liver disease is a pro-inflammatory condition Read More »
Sildenafil (Viagra®) down regulates cytokines and prevents demyelination in a cuprizone-induced MS mouse model Cytokine. 2012 Jun 30; Authors: Nunes AK, Rapôso C, Luna RL, Cruz-Höfling MA, Peixoto CA Abstract Sildenafil induces cGMP accumulation through phosphodiesterase-5 (PDE5) inhibition. cGMP-pathways protect oligodendrocytes and modulate astroglial and microglial reactions. Microglia and astrocytes play an important role in …
Poor nutrition at age 3 and schizotypal personality at age 23: the mediating role of age 11 cognitive functioning. Am J Psychiatry. 2012 Aug 1;169(8):822-30 Authors: Venables PH, Raine A Abstract OBJECTIVE: Poor prenatal nutrition has been associated with schizophrenia spectrum disorders in the Netherlands and China, and it has been suggested that perinatal and postnatal …
A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents. Am J Psychiatry. 2012 Aug 1;169(8):805-12 Authors: Gray KM, Carpenter MJ, Baker NL, Desantis SM, Kryway E, Hartwell KJ, McRae-Clark AL, Brady KT Abstract OBJECTIVE: Preclinical findings suggest that the over-the-counter supplement N-acetylcysteine (NAC), via glutamate modulation in the nucleus accumbens, holds promise as …
Metformin for treatment of antipsychotic-induced amenorrhea and weight gain in women with first-episode schizophrenia: a double-blind, randomized, placebo-controlled study Am J Psychiatry. 2012 Aug 1;169(8):813-21 Authors: Wu RR, Jin H, Gao K, Twamley EW, Ou JJ, Shao P, Wang J, Guo XF, Davis JM, Chan PK, Zhao JP Abstract OBJECTIVE: Data on the treatment …
DHEA and DHEA-S response to acute psychosocial stress in healthy men and women Biol Psychol. 2012 May;90(2):143-9DHEA and DHEA-S response to acute psychosocial stress in healthy men and women. Authors: Lennartsson AK, Kushnir MM, Bergquist J, Jonsdottir IH Abstract This study investigates the effect of acute psychosocial stress on serum concentrations of DHEA and DHEA-S …
DHEA and DHEA-S increase in response to acute psychosocial stress Read More »
Glucocorticoids Protect Against the Delayed Behavioral and Cellular Effects of Acute Stress on the Amygdala. Biol Psychiatry. 2012 May 7; Authors: Rao RP, Anilkumar S, McEwen BS, Chattarji S Abstract BACKGROUND: A single episode of acute immobilization stress has previously been shown to trigger a delayed onset of anxiety-like behavior and spinogenesis in the basolateral …
Glucocorticoids Protect Against Effects of Stress on the Amygdala Read More »
Hippocampal Angiogenesis and Progenitor Cell Proliferation Are Increased with Antidepressant Use in Major Depression. Biol Psychiatry. 2012 May 30; Authors: Boldrini M, Hen R, Underwood MD, Rosoklija GB, Dwork AJ, Mann JJ, Arango V Abstract BACKGROUND: Adult neurogenesis is coupled to angiogenesis in neurogenic niches in the dentate gyrus (DG) and increased by antidepressants in rodents. …
Antidepressants are still useful – they increase neurogenesis and angiogenesis Read More »
Estrogen levels are associated with extinction deficits in women with posttraumatic stress disorder. Biol Psychiatry. 2012 Jul 1;72(1):19-24. Epub 2012 Apr 12. Glover EM, Jovanovic T, Mercer KB, Kerley K, Bradley B, Ressler KJ, Norrholm SD. Abstract BACKGROUND:Women are twice as likely to develop posttraumatic stress disorder (PTSD) than men. As shown in our previous work, …
Low Estrogen Predisposes Women to Posttraumatic Stress Disorder. Read More »
Telomeres and Early-Life Stress: An Overview Biol Psychiatry. 2012 Jul 23; Authors: Price LH, Kao HT, Burgers DE, Carpenter LL, Tyrka AR Abstract The long-term sequelae of adverse early-life experiences have long been a focus in psychiatry, with a historic neurobiological emphasis on physiological systems that are demonstrably stress-responsive, such as the hypothalamic-pituitary-adrenal axis and …