The Nature of Dopamine Dysfunction in Schizophrenia and What This Means for Treatment: Meta-analysis of Imaging Studies Arch Gen Psychiatry. 2012 Apr 2; Authors: Howes OD, Kambeitz J, Kim E, Stahl D, Slifstein M, Abi-Dargham A, Kapur S Abstract CONTEXT: Current drug treatments for schizophrenia are inadequate for many patients, and despite 5 decades …
Chronic Activation of Corticotropin-Releasing Factor Type 2 Receptors Reveals a Key Role for 5-HT1A Receptor Responsiveness in Mediating Behavioral and Serotonergic Responses to Stressful Challenge. Biol Psychiatry. 2012 Jun 13; Authors: Neufeld-Cohen A, Kelly PA, Paul ED, Carter RN, Skinner E, Olverman HJ, Vaughan JM, Issler O, Kuperman Y, Lowry CA, Vale WW, Seckl …
Type 2 Corticotropin-Releasing Factor Receptor Stimulation Increases Anxiety Read More »
Simple Viewing Tests Can Detect Eye Movement Abnormalities That Distinguish Schizophrenia Cases from Controls with Exceptional Accuracy. Biol Psychiatry. 2012 May 22; Authors: Benson PJ, Beedie SA, Shephard E, Giegling I, Rujescu D, St Clair D Abstract BACKGROUND: We have investigated which eye-movement tests alone and combined can best discriminate schizophrenia cases from control …
Why do some depressed outpatients who are in remission according to the Hamilton Depression Rating Scale not consider themselves to be in remission? J Clin Psychiatry. 2012 Jun;73(6):790-5 Authors: Zimmerman M, Martinez JA, Attiullah N, Friedman M, Toba C, Boerescu DA, Rahgeb M Abstract OBJECTIVE: In treatment studies of depression, remission is typically defined narrowly, based …
Arterial Stiffness and Vitamin D Levels: the Baltimore Longitudinal Study of Aging J Clin Endocrinol Metab. 2012 Jul 5; Authors: Giallauria F, Milaneschi Y, Tanaka T, Maggio M, Canepa M, Elango P, Vigorito C, Lakatta EG, Ferrucci L, Strait J Abstract Context: The importance of vitamin D for bone health has long been acknowledged. Recent evidence …
Sitagliptin Exerts an Antinflammatory Action J Clin Endocrinol Metab. 2012 Jun 28; Authors: Makdissi A, Ghanim H, Vora M, Green K, Abuaysheh S, Chaudhuri A, Dhindsa S, Dandona P Abstract Context: Sitagliptin is an inhibitor of the enzyme dipeptidyl peptidase-IV (DPP-IV), which degrades the incretins, glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide, and thus, sitagliptin increases …
Sitagliptin (Januvia) has antiinflammatory effects Read More »
Circulating interferon-γ correlates with 1,25(OH)D and the 1,25(OH)D-to-25(OH)D ratio Cytokine. 2012 Jun 14; Authors: Barker T, Martins TB, Kjeldsberg CR, Trawick RH, Hill HR Abstract The mechanism responsible for the decrease in vitamin D status (i.e., plasma or serum 25-hydroxyvitamin D (25(OH)D) concentration) during inflammatory stress is unknown in humans. Interferon (IFN)-γ is an inflammatory …
Effect of resveratrol and modulation of cytokine production on human periodontal ligament cells Cytokine. 2012 Jun 28; Authors: Rizzo A, Bevilacqua N, Guida L, Annunziata M, Romano Carratelli C, Paolillo R Abstract Periodontitis is a multifactorial polymicrobial infection characterized by a destructive inflammatory process. Porphyromonas gingivalis, a Gram-negative anaerobic black-pigmented rod, which produces several …
Dietary flaxseed oil reduces adipocyte size, adipose monocyte chemoattractant protein-1 levels and T-cell infiltration in obese, insulin-resistant rats Cytokine. 2012 Aug;59(2):382-91 Authors: Baranowski M, Enns J, Blewett H, Yakandawala U, Zahradka P, Taylor CG Abstract BACKGROUND: Adipocyte dysfunction is characterized by an increase in adipocyte size and changes to their adipokine profiles. Immune cell infiltration …
Effect of vitamin D(3) on chemokine expression in pulmonary tuberculosis Cytokine. 2012 Jul 14; Authors: Selvaraj P, Harishankar M, Singh B, Banurekha VV, Jawahar MS Abstract 1,25 Dihydroxy vitamin D(3) (vitamin D(3)) is an immunomodulator and its deficiency has been associated with susceptibility to tuberculosis. We have studied the immunoregulatory role of vitamin D(3) on …
Effect of vitamin D(3) on chemokine expression in pulmonary tuberculosis. Read More »