Author name: Romeo Mariano, M.D.

Seroquel Reduces Autoimmune-Mediated Demyelination and IL-2

Quetiapine, an Atypical Antipsychotic, Is Protective against Autoimmune-Mediated Demyelination by Inhibiting Effector T Cell Proliferation Feng Mei, Sheng Guo, Yangtao He, Linyun Wang, Hongkai Wang, Jianqin Niu, Jiming Kong, Xinmin Li, Yuzhang Wu, Lan Xiao PLoS One. 2012;7(8):e42746. Epub 2012 Aug 13. Abstract Quetiapine (Que), a commonly used atypical antipsychotic drug (APD), can prevent myelin …

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Mental Fatigue Associated with Sympathetic Hyperactivity

Mental fatigue caused by prolonged cognitive load associated with sympathetic hyperactivity Behav Brain Funct. 2011;7:17 Mizuno K, Tanaka M, Yamaguti K, Kajimoto O, Kuratsune H, Watanabe Y Abstract BACKGROUND: It is known that chronic fatigue is associated with sympathetic hyperactivity. However, the relationship between autonomic function and mental fatigue caused by a prolonged mental load …

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Testosterone is anti-inflammatory

The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men J Clin Endocrinol Metab. 2004 Jul;89(7):3313-8 Malkin CJ, Pugh PJ, Jones RD, Kapoor D, Channer KS, Jones TH. Abstract Testosterone has immune-modulating properties, and current in vitro evidence suggests that testosterone may suppress the expression of the proinflammatory cytokines TNF-alpha, …

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Stress, food, and inflammation

Stress, food, and inflammation: psychoneuroimmunology and nutrition at the cutting edge    Psychosom Med. 2010 May;72(4):365-9 Kiecolt-Glaser JK Abstract Inflammation is the common link among the leading causes of death. Mechanistic studies have shown how various dietary components can modulate key pathways to inflammation, including sympathetic activity, oxidative stress, transcription factor nuclear factor-kappaB activation, and …

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Schizophrenia and anti-inflammatory therapy

Schizophrenia genes, epigenetics and psychoneuroimmunology therapeutics: all make sense now? J Psychopharmacol. 2011 Jun;25(6):713-4 Müller N, Dursun SM Abstract Genetics, epigenetics, infection as an environmental factor, functional findings for the immune system, and a therapeutic approach with anti-inflammatory therapy provide evidence for a pivotal role of the immune system in schizophrenia. This field, therefore, should …

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Seizures cause inflammation which sustains seizure recurrence and causes blood-brain barrier damage.

Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage Ann Neurol. 2012 Jul;72(1):82-90 Librizzi L, Noè F, Vezzani A, de Curtis M, Ravizza T Abstract OBJECTIVE: Epilepsy is a common neurological disorder characterized by recurrent seizures often unresponsive to pharmacological treatment. Brain inflammation is considered a crucial etiopathogenetic mechanism of epilepsy that could be …

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Psychoneuroimmunologic Factors In Inflammatory Bowel Disease

Psychoneuroimmunologic factors in inflammatory bowel disease Inflamm Bowel Dis. 2011 Mar;17(3):849-57 Authors: Mackner LM, Clough-Paabo E, Pajer K, Lourie A, Crandall WV Abstract BACKGROUND: Bidirectional relationships between the immune system, nervous system, and psychological processes likely exist in inflammatory bowel disease (IBD) because stress can affect IBD, and IBD is associated with an increased risk …

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