Author name: Romeo Mariano, M.D.

Pergolide Treatment of Cognitive Deficits Associated with Schizotypal Personality Disorder: Continued Evidence of the Importance of the Dopamine System in the Schizophrenia Spectrum. Neuropsychopharmacology. 2010 Feb 3; Authors: McClure MM, Harvey PD, Goodman M, Triebwasser J, New A, Koenigsberg HW, Sprung LJ, Flory JD, Siever LJ Cognitive deficits observed in schizophrenia are also frequently found …

Pergolide Reduces Cognitive Deficits Associated with Schizotypal Personality Disorder Read More »

Exogenous cortisol enhances aggressive behavior in females, but not in males. Psychoneuroendocrinology. 2010 Feb 1; Böhnke R, Bertsch K, Kruk MR, Richter S, Naumann E The hypothalamic-pituitary-adrenal (HPA) axis plays a major role in the development, elicitation, and enhancement of aggressive behavior in animals. Increasing evidence suggests that this is also true for humans. Here, …

Supressing HPA Axis Activity via Exogenous Cortisol Enhances Aggressive Behavior in Females, but not in Males. Read More »

Long-Chain {omega}-3 Fatty Acids for Indicated Prevention of Psychotic Disorders: A Randomized, Placebo-Controlled Trial. Arch Gen Psychiatry. 2010 Feb;67(2):146-54 Amminger GP, Schäfer MR, Papageorgiou K, Klier CM, Cotton SM, Harrigan SM, Mackinnon A, McGorry PD, Berger GE CONTEXT: The use of antipsychotic medication for the prevention of psychotic disorders is controversial. Long-chain omega-3 (omega-3) polyunsaturated …

Omega-3 Fatty Acids for Prevention of Psychotic Disorders Read More »

Primate Early Life Stress Leads to Long-Term Mild Hippocampal Decreases in Corticosteroid Receptor Expression. Biol Psychiatry. 2010 Feb 2; Arabadzisz D, Diaz-Heitjz R, Knuesel I, Weber E, Pilloud S, Dettling AC, Feldon J, Law AJ, Harrison PJ, Pryce CR BACKGROUND: Expression of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) genes are moderately reduced in several …

Stress Leads to Long-Term Reduction in Corticosteroid Sensitivity in the Hippocampus Read More »

Blueberry Juice May Boost Memory (Via WebMD Health.) ———- Blueberry Supplementation Improves Memory in Older Adults J Agric Food Chem. 2010 Jan 4. [Epub ahead of print] Krikorian R, Shidler MD, Nash TA, Kalt W, Vinqvist-Tymchuk MR, Shukitt-Hale B, Joseph JA. The prevalence of dementia is increasing with expansion of the older adult population. In …

Blueberry Juice May Boost Memory Read More »

Reduced capacity to sustain positive emotion in major depression reflects diminished maintenance of fronto-striatal brain activation.: “ Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22445-50 Authors: Heller AS, Johnstone T, Shackman AJ, Light SN, Peterson MJ, Kolden GG, Kalin NH, Davidson RJ Anhedonia, the loss of pleasure or interest in previously rewarding stimuli, …

Inability to sustain positive emotion in Major Depression reflects failure to maintain Nucleus Accumbens activity Read More »

Brain Scan Offers First Biological Test in Diagnosis of Post-Traumatic Stress Disorder Scientific American – Psychiatry 1/22/10 Carina Storrs The synchronous neural interactions test as a functional neuromarker for post-traumatic stress disorder (PTSD): a robust classification method based on the bootstrap. J Neural Eng. 2010 Feb;7(1):16011. Epub 2010 Jan 20. Georgopoulos AP, Tan HR, Lewis …

Brain Scan for Post-Traumatic Stress Disorder Read More »

The anxiolytic effect of environmental enrichment is mediated via amygdalar CRF receptor type 1. Mol Psychiatry. 2010 Jan 19; Authors: Sztainberg Y, Kuperman Y, Tsoory M, Lebow M, Chen A Environmental enrichment (EE) is known to have an anxiolytic effect in several animal models; however, the molecular mechanisms underlying these behavioral changes are not understood. …

Reduction in CRF Receptor type 1 expression in the Amygdala reduces Anxiety Read More »

CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):912-7 Authors: Huising MO, van der Meulen T, Vaughan JM, Matsumoto M, Donaldson CJ, Park H, Billestrup N, Vale WW Corticotropin-releasing factor (CRF), originally characterized as the …

CRF stimulates Pancreatic Beta Cell Insulin Secretion and Beta Cell Proliferation Read More »

Levetiracetam inhibits interleukin-1beta inflammatory responses in the hippocampus and piriform cortex of epileptic rats. Neurosci Lett. 2010 Jan 14; Authors: Kim JE, Choi HC, Song HK, Jo SM, Kim DS, Choi SY, Kim YI, Kang TC Levetiracetam (LEV, 2S-(oxo-1-pyrrolidinyl)butanamide, Keppra(R), UCB Pharma) is a new antiepileptic drug used to treat certain types of seizures in …

Levetiracetam inhibits interleukin-1beta inflammatory responses in the hippocampus and piriform cortex Read More »