Author name: Romeo Mariano, M.D.

Circulating interferon-γ correlates with 1,25(OH)D and the 1,25(OH)D-to-25(OH)D ratio Cytokine. 2012 Jun 14; Authors: Barker T, Martins TB, Kjeldsberg CR, Trawick RH, Hill HR Abstract The mechanism responsible for the decrease in vitamin D status (i.e., plasma or serum 25-hydroxyvitamin D (25(OH)D) concentration) during inflammatory stress is unknown in humans. Interferon (IFN)-γ is an inflammatory …

Inflammatory Illnesses Decrease Vitamin D 25 OH by Increasing Conversion to Vitamin D 25 Dihydroxy Read More »

Effect of resveratrol and modulation of cytokine production on human periodontal ligament cells Cytokine. 2012 Jun 28; Authors: Rizzo A, Bevilacqua N, Guida L, Annunziata M, Romano Carratelli C, Paolillo R Abstract   Periodontitis is a multifactorial polymicrobial infection characterized by a destructive inflammatory process. Porphyromonas gingivalis, a Gram-negative anaerobic black-pigmented rod, which produces several …

Resveratrol vs. Brushing and Flossing Read More »

Dietary flaxseed oil reduces adipocyte size, adipose monocyte chemoattractant protein-1 levels and T-cell infiltration in obese, insulin-resistant rats Cytokine. 2012 Aug;59(2):382-91 Authors: Baranowski M, Enns J, Blewett H, Yakandawala U, Zahradka P, Taylor CG Abstract BACKGROUND: Adipocyte dysfunction is characterized by an increase in adipocyte size and changes to their adipokine profiles. Immune cell infiltration …

Flaxseed oil reduces adipocyte size, adipose monocyte chemoattractant protein-1 levels and T-cell infiltration Read More »

Effect of vitamin D(3) on chemokine expression in pulmonary tuberculosis Cytokine. 2012 Jul 14; Authors: Selvaraj P, Harishankar M, Singh B, Banurekha VV, Jawahar MS Abstract 1,25 Dihydroxy vitamin D(3) (vitamin D(3)) is an immunomodulator and its deficiency has been associated with susceptibility to tuberculosis. We have studied the immunoregulatory role of vitamin D(3) on …

Effect of vitamin D(3) on chemokine expression in pulmonary tuberculosis. Read More »

Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease Cytokine. 2012 Aug;59(2):442-9 Authors: Coulon S, Francque S, Colle I, Verrijken A, Blomme B, Heindryckx F, De Munter S, Prawitt J, Caron S, Staels B, Van Vlierberghe H, Van Gaal L, Geerts A Abstract The liver is a major target of injury …

Non-alcoholic fatty liver disease is a pro-inflammatory condition Read More »

Sildenafil (Viagra®) down regulates cytokines and prevents demyelination in a cuprizone-induced MS mouse model Cytokine. 2012 Jun 30; Authors: Nunes AK, Rapôso C, Luna RL, Cruz-Höfling MA, Peixoto CA Abstract Sildenafil induces cGMP accumulation through phosphodiesterase-5 (PDE5) inhibition.  cGMP-pathways protect oligodendrocytes and modulate astroglial and microglial reactions. Microglia and astrocytes play an important role in …

Does this mean Viagra can treat depression? Read More »

Poor nutrition at age 3 and schizotypal personality at age 23: the mediating role of age 11 cognitive functioning.   Am J Psychiatry. 2012 Aug 1;169(8):822-30 Authors: Venables PH, Raine A Abstract OBJECTIVE: Poor prenatal nutrition has been associated with schizophrenia spectrum disorders in the Netherlands and China, and it has been suggested that perinatal and postnatal …

Substitute Autism for this finding: Poor nutrition at age 3 is associated with schizotypal personality at age 23 Read More »

A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents.   Am J Psychiatry. 2012 Aug 1;169(8):805-12 Authors: Gray KM, Carpenter MJ, Baker NL, Desantis SM, Kryway E, Hartwell KJ, McRae-Clark AL, Brady KT Abstract OBJECTIVE: Preclinical findings suggest that the over-the-counter supplement N-acetylcysteine (NAC), via glutamate modulation in the nucleus accumbens, holds promise as …

N-acetylcysteine reduces Cannabis Dependence Read More »

Metformin for treatment of antipsychotic-induced amenorrhea and weight gain in women with first-episode schizophrenia: a double-blind, randomized, placebo-controlled study   Am J Psychiatry. 2012 Aug 1;169(8):813-21 Authors: Wu RR, Jin H, Gao K, Twamley EW, Ou JJ, Shao P, Wang J, Guo XF, Davis JM, Chan PK, Zhao JP Abstract OBJECTIVE: Data on the treatment …

Metformin reduces antipsychotic-induced amenorrhea and weight gain in women with schizophrenia Read More »

DHEA and DHEA-S response to acute psychosocial stress in healthy men and women Biol Psychol. 2012 May;90(2):143-9DHEA and DHEA-S response to acute psychosocial stress in healthy men and women. Authors: Lennartsson AK, Kushnir MM, Bergquist J, Jonsdottir IH Abstract This study investigates the effect of acute psychosocial stress on serum concentrations of DHEA and DHEA-S …

DHEA and DHEA-S increase in response to acute psychosocial stress Read More »