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  • August 29, 2012 at 7:12 am #1710
    Jean
    Member

    Metformin look interesting for the prevention of some cancers, it’s help to increase AMK, new neurons.

    http://www.impactaging.com/papers/v2/n11/pdf/100230.pdf

    August 29, 2012 at 2:57 pm #4769
    DrMariano2
    Participant

    Metformin can cause an imbalance between the brain’s need for gluconeogenesis and the livers ability to provide sugar for the brain. This is one reason I would have to carefully weigh the risks and benefits of treatment, particularly if one does not have insulin resistance.

    August 31, 2012 at 8:10 am #4770
    Jean
    Member

    @DrMariano 4620 wrote:

    Metformin can cause an imbalance between the brain’s need for gluconeogenesis and the livers ability to provide sugar for the brain. This is one reason I would have to carefully weigh the risks and benefits of treatment, particularly if one does not have insulin resistance.

    May be berberine is a good option to increase AMPK with exercise.

    http://naturalmedicinejournal.net/pdf/NMJ_OCT10_LRberb.pdf

    August 31, 2012 at 8:57 am #4768
    DrMariano2
    Participant

    Metformin generally needs to be coupled to a treatment that increases insulin sensitivity more evenly than it. This would help reduce the risk of treatment with Metformin alone.

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