Hello,

I have read that dopamine agonists have been used sometimes for sexual dysfunction in that they decrease prolactin. I have learned that sometimes prolactin is found to be higher in those with autoimmune diseases.

I was diagnosed with Hashimoto’s thyroid disease about two years ago (based on TPO antibody so high the lab stopped counting) for which I have been taking 0.75 mcg levoxyl. DXA scan revealed osteopenia, for which I have been taking an oral bisphosphonate over the past year.

I have nocturnal emissions every two weeks, but have never ejaculated while awake. I also have ED and had congenital curvature of the penis/Peyronie’s.

My FSH level has also been at the low end of normal, and my PRL is at the higher end of normal, so I am concerned that a dopamine agonist might lower my FSH further. I have never had an MRI of my pituitary and wonder if that is warranted.

Although I’ve learned that bromocriptine can raise FSH, I know ergot-derived dopamine agonists (bromocriptine/cabergoline) are associated with fibrosis. Considering the history of Peyronie’s disease and Hashimoto’s association with mitral valve prolapse, I am hesitant to try that kind.

Mucuna pruriens and possibly vitamin B6 decrease prolactin, but they also decrease FSH.

I’ve read that pramipexole isn’t associated with fibrosis, but I’ve haven’t been able to find what effect it has on FSH. I’ve also not been able to find a study of daily, continued use of either the immediate-release or extended-release pramipexole’s effects on healthy men’s prolactin and FSH levels. Has anyone seen a study or know from experience?

Could prolactin levels be brought down by a higher dose of levoxyl? If so, how rapidly could one do that?

How could one increase FSH without causing changes to anything else?

Results of most recent labs:

LH: 4.3 (Ref range: 1.7-8.6)
FSH: 1.9 (Ref range: 1.5-12.4)
PRL: 12.0 (Ref range: 4.0-15.2)
T, total: 465 (Ref range: 350-1030)
T, free: 12.20 (Ref range: 5.00-21.00)
T, % free: 2.65 (Ref range: 1.50-4.20)
SHBG: 29.0 (Ref range: 14.5-48.4)
Alpha subunit, free: 0.09 (Ref range: 0.05-0.53)
DHEA-S: 188.0 (Ref range: 88.9-427.0)
IGF-1: 182 (Ref range: 109-284)
TSH: 3.560 (Ref range: 0.45-4.500)
T4, free: 1.45 (Ref range: 0.82-1.77)
T3, free: 3.3 (Ref range: 2.0-4.4)
Vit D, 25-hydroxy: 52.6 (Ref range: 32.0-100.0)

Thank you.