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Two months ago I did restart that lasted 45 days. I was a combo of hcg, clomid and nolvedax. Nolvedex was the only med that I did for the full 45 days. My testicles where hanging down almost at normal size while on it. This protocol ended the last week of July.I was on thyroid meds and seemed ok. But the last 2 weeks on nolvadex I started experiencing testicular shrinkage again and feeling cold. My body temp has ranged from high 95’s to mid 96’s out of no where this happens. All I changed during that time was my breakfast. I changed from eating eggs to making a shake with avocado, kale, spinach, fish oil and grapefruit.
I though maybe the high fiber in this shake was causing my thyroid meds not to absorb correctly so I stopped and went back to eating just eggs. I though this would of helped, but my morning temp is still 95’s to mid 96’s and on some good days in the afternoon it will read low 97’s. My zinc is on the high end of the normal range and ferritin is fine too. Iron was in mid range too.
Why would my testicles go from being almost normal size to completely small again during the last two weeks on nolavdex? I’ve been off nolvadex for 3 weeks now and small testicle have not improved.
Would low thyroid do this? I feel tired all day long and exuasted, but my morning cortisol is in the top range. Taking 20mg of HC per day and don’t feel anything on it as far as energy.
My total T-levels where like 378 two weeks after my restart ended (3 weeks ago) and estrogen ultra sensitive was I think 32-33.
I’m afraid my t-levels will drop more. The only positive thing is I know my body can produce normal amount of testosterone if everything is normal.
What do you feel would of caused this? Would lowering my estrogen raise my testosterone significantly?
Tamoxifen, as a weak estrogen, blocks estrogen signaling in the brain, causing the brain to release more Luteinzing Hormone to stimulate estrogen production by stimulating testesterone and aromatase production from the testes.
Grapefruit contains substances that block the effect of enzyme cytochrome P-450 3A4 (CYP-3A4), which is the major enzyme that breaks down the numerous estrogens and other medications. Blocking CYP-3A4 can cause the affected medications to build up to sometimes toxic doses. Estrogens can accumulate when CYP-3A4 is blocked. High estrogen levels can weaken testosterone signaling.
Medications, such as Tegretol and St. John’s Wort, which stimulate CYP-3A4 production weaken the effects of numerous other medications and hormones. In particular, they weaken the effects of birth control pills, increasing the risk for pregnancy – with the further risk of birth defects when pregnant on birth control pills.
@DrMariano 3241 wrote:
Tamoxifen, as a weak estrogen, blocks estrogen signaling in the brain, causing the brain to release more Luteinzing Hormone to stimulate estrogen production by stimulating testesterone and aromatase production from the testes.
Grapefruit contains substances that block the effect of enzyme cytochrome P-450 3A4 (CYP-3A4), which is the major enzyme that breaks down the numerous estrogens and other medications. Blocking CYP-3A4 can cause the affected medications to build up to sometimes toxic doses. Estrogens can accumulate when CYP-3A4 is blocked. High estrogen levels can weaken testosterone signaling.
Medications, such as Tegretol and St. John’s Wort, which stimulate CYP-3A4 production weaken the effects of numerous other medications and hormones. In particular, they weaken the effects of birth control pills, increasing the risk for pregnancy – with the further risk of birth defects when pregnant on birth control pills.
Do you think since I have gut inflammation problems that maybe my intestine were not absorbing my thyroid meds? Every morning I had been taking my temperature and it was always 95’s-96s, but after a few days of antibiotics and other meds for this issue, I took my temperature today and it was around 97.4?
Could my intestine be absorbing my thyroid meds better?
I can’t apply information to you specifically, since I haven’t examined you.
What other medications are you referring to?
Some antibiotics have anti-inflammatory effects independent of their antibiotic effects. Some even have antidepressant effects – such as monoamine oxidase inhibition – that is independent of their antibiotic effects. These other mechanisms of actions may not be well documented because they may not be tested for. There are a lot of holes in the fund of information in science since not everything can be tested.
If the anti-inflammatory effects affect thyroid metabolism positively, then thyroid function can improve independently of intestinal absorption, independently of gut infection or non-infection.
Thus, one can’t totally speculate on whether or not a bacterial kill off is occurring with antibiotic treatment unless there is proof it occurred, given other mechanisms of action that antibiotics can have.
I wonder if the discomfort from a hypothesized bacterial kill off may be instead occur as a result of a direct anti-inflammatory effect of an antibiotic, which then improves thyroid metabolism, which then leads, in some cases, to excess thyroid hormone signaling, which then can overactivate the immune system, triggering stress and sickness behaviors. The situation is complicated with the interactions involved.
@DrMariano 3245 wrote:
I can’t apply information to you specifically, since I haven’t examined you.
What other medications are you referring to?
Some antibiotics have anti-inflammatory effects independent of their antibiotic effects. Some even have antidepressant effects – such as monoamine oxidase inhibition – that is independent of their antibiotic effects. These other mechanisms of actions may not be well documented because they may not be tested for. There are a lot of holes in the fund of information in science since not everything can be tested.
If the anti-inflammatory effects affect thyroid metabolism positively, then thyroid function can improve independently of intestinal absorption, independently of gut infection or non-infection.
Thus, one can’t totally speculate on whether or not a bacterial kill off is occurring with antibiotic treatment unless there is proof it occurred, given other mechanisms of action that antibiotics can have.
I wonder if the discomfort from a hypothesized bacterial kill off may be instead occur as a result of a direct anti-inflammatory effect of an antibiotic, which then improves thyroid metabolism, which then leads, in some cases, to excess thyroid hormone signaling, which then can overactivate the immune system, triggering stress and sickness behaviors. The situation is complicated with the interactions involved.
Dr. M,
I’ve taking my temperature more often since taking antibiotics for my gut and think I maybe absorbing my thyroid meds better. Every day I wake up and take my temp prior to antibiotic treatment, and it was always high 95’s to low 96’s. Now after 5 days of treatment my morning temp is high 96’s in the morning and 98.6 in the afternoon. This was today’s stats, but who knows if it’s going to be consistent. Should my morning temp also be at in around 98.6 as well?Temperature is going to vary throughout the day.
The warmest temperature is generally going to be in the afternoon.
The lowest temperature is going to be in the morning. This is why it is called a basal temperature. It will generally be significantly lower than 98.6 degrees. If it was 98.6 degrees, I would worry about the person having a fever.
The basal temperature is the temperature before other systems kick in to modify thyroid signaling and increase metabolic activity. I generally don’t advocate monitoring treatment by taking a basal temperature. It generally does not give me an idea about how clinically the person is functioning during the day.
Thyroid hormone does not work in a vacuum with the other systems in the body. There are interactions with the rest of the system that improve as the day progresses. For example, the stress system kicks in the morning to wake a person up, to increase thyroid deiodinase enzyme production, to increase gluconeogenesis, to increase adrenal cortisol output, to increase respirations in order to improve oxygenation of the body, etc. etc. All of these changes take time to kick in before the person is fully active in thyroid signaling. This may explain why the worse time for alertness in people is just after the wake up in the morning.
Like a car engine needing to heat up to become more efficient, the body also has to warm up.
Thus, I prefer measuring temperature after some level of activity – such as just before lunch. This gives me a better idea of how the person is responding to thyroid treatment.
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