450,

Although it seems logical, I would hold off on that. I am in a similiar situation as you. The problem is, not only could this be a dangerous combination (serotonin syndrome), but your dopamine could drop make you feel like a zombie. Are you on an SSRI now? If not, I would give Lexapro a shot before this combo. I have had zero sex sides on Lexapro.

@The450Man 2132 wrote:

Remeron+Trazadone+ssri

reasoning=

-tired of anxiety and eating klonopin like candy when i go out
-from what ive read…. most therapeutic effects of ssri’s stems from 5ht1a activation, undesirable effects come from activation of 5ht2 5ht3 receptors (possibly more from the other handful of known receptors)

Blocking 5ht2a, 5ht2b, 5ht2c, 5ht3 receptors should “push” more of the serotonin towards the 5ht1 receptor(s) and prevent common ssri side effects like sexual dysfunction and nausea allowing a lower dose of an ssri.

granted i know this is way more complex then what im making it…

You’re right. Serotonin Syndrome is too strong of a statement. I take 10mg Lexapro everyday. One time I took a trazadone to help me sleep. The following day I was a zombie. I had no drive, no creative or strategic thinking, etc. Basically low dopamine symptoms. Another consideration could be taking Buspar to help with anxiety. A lot of times it is hard to determine between anxiety, depression, and that overwhelming feeling. It’s a catch 22 because when I had that zombie day, I actually became more anxious and overwhelmed because I couldn’t function. More of a reason why all the neurotransmitters play a part in your sense of well being.

@The450Man 2149 wrote:

i doubt serotonin syndrome would be an issue here.

But you do raise a point I diddnt think of. Since the antagonists are blocking serotonin from activating said receptors, it can only go somewhere else. Heavy bombardment of 5ht1? 5ht4 and up?

And about the dopamine.. the main issue from ssri’s and dopamine is activation of 5ht2 receptors inhibiting dopamine release. I cant remember the subtypes but its in that relm lol… i think.